Effect of Peganum harmala L. extract supplemented ISP2 medium on growth and production of secondary metabolites of Streptomyces ayarius S115

Identification and Antibacterial Activity of Streptomyces mediolani CF51DZ Isolated from the Beetle (Protaetia morio), Collected from Souk Ahras, North-East of Algeria

“…The antibacterial activity of CF51DZ was tested by diffusion on agar wells. 8 In brief, wells of 6 mm in diameter were formed by a sterile well driller on Muller Hinton agar medium previously inoculated with pathogenic bacteria (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Staphylococcus aureus ATCC 29213) obtained from the Laboratory of Organic Chemistry and Interdisciplinary (Research's Team: valorization of active biomolecules), University of Souk-Ahras, Algeria. After centrifugation at 8000 rpm/20 min, 80 μl of supernatant) of liquid culture of strain CF51DZ was deposited in well.…”

“…6,7 Discovery of new secondary metabolites as bioactive molecules in unexplored habitats is pointed out as strategic actions to fight against the growing number of microorganisms that are resistant to a wide range of antibiotics obtained from actinomycetes. 8 Many actinobacteria, including Streptomycetes have been isolated as appropriate defensive partners associated withvarious types of insects, 9 and in this regard, Streptomyces and Pseudonocardia were reported to protect the leaf-cuttingants against pathogenic fungus. 10 Additionally, these insect-associated actinomycetes are possibly found in various female beewolf wasps, providing a specialized antennal reservoir for cultivating Streptomyces philanthi, and cover the cocoon wall to protect larva against pathogens.…”