Effect of pegbovigrastim on fertility and culling in grazing dairy cows and its association with prepartum nonesterified fatty acids

Development potential of selenium in the prevention and treatment of bovine endometritis

“…Considering the problem of drug residues and the increasing resistance of pathogenic bacteria such as Escherichia coli ( E. coli ) and Trueperella pyogenes ( T. pyogenes ), many alternatives for treating endometritis, such as herbs (plant extracts or prescriptions composed of various plants), probiotics, bacteriophages, essential oils, vaccines, pegbovigrastim, nanoparticles, biomaterials, ozone, etc. are being studied (Barca et al., 2022; Escandón et al., 2020; Galvão et al., 2020; Genís et al., 2018; Gurunathan et al., 2018; Huang et al., 2018; Machado et al., 2012; Paiano, de Sousa, et al., 2023; Pinedo et al., 2015). This paper reviews previous studies on the regulatory effect of Se on animal functions and analyses the feasibility of Se in preventing and treating endometritis, aiming to provide a new idea for the development of new drugs in the future.…”

Pegbovigrastim use in periparturient embryo-recipient cows: Effects on health and reproduction

“…No differences were observed between CON and PEG-treated cows in early-lactation reproductive performance outcomes ( Table 3 ). Previous randomized studies reported that PEG did not affect reproductive performance when days to first service and pregnancy rate were assessed in dairy cows ( Zinicola et al, 2018 ; Van Schyndel et al, 2021 ; Barca et al, 2022 ). To our knowledge, no previous studies have evaluated the effects of PEG on days to first heat or number of inseminations.…”

“…One of the mechanisms of placental detachment is the breakdown of the extracellular matrix by maternal neutrophils, which release matrix metalloproteinase under the action of proinflammatory cytokines, such as IL-8 ( Kimura et al, 2002 ; Nelli et al, 2019 ). Dairy cows are at a higher risk for RFM when periparturient immune cell dysfunction occurs and placental extracellular matrix breakdown is impaired ( Galvão et al, 2010 ; Barca et al, 2022 ). For this reason, immunomodulators that potentiate the inflammatory response of immune cells, especially neutrophils and other polymorphonuclear cells, could increase the efficacy of immune function around parturition ( Stabel et al, 1991 ).…”