Effect of PEGylated superparamagnetic iron oxide nanoparticles (SPIONs) under magnetic field on amyloid beta fibrillation process

Mirsadeghi, Somayeh; Shanehsazzadeh, Saeed; Atyabi, Fatemeh; Dinarvand, Rassoul

doi:10.1016/j.msec.2015.10.026

Cited by 59 publications

(34 citation statements)

References 47 publications

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“…Depending on the size and the surface area, a dual effect on the Aβ fibrillation kinetics was observed, with lower concentrations of SPIONs decreasing the rate of Aβ fibrillation, while higher concentrations enhanced the rate in the aqueous solution (Mahmoudi et al, 2013). Consistent with the previous study, Mirsadeghi et al (2016) showed that lower concentrations of SPIONs coated by PEG-NH2 inhibited the process of Aβ fibrillation under magnetic field, whereas high concentrations accelerated the process. Furthermore, the coating charge also exerts a considerable effect on the Aβ fibrillation process.…”

Section: Application Of Iron Oxide Nanoparticles In the Treatment Of Adsupporting

confidence: 88%

“…Furthermore, the coating charge also exerts a considerable effect on the Aβ fibrillation process. In comparison with the negatively charged or uncharged SPIONs, lower concentrations of SPIONs with positive coating charge promoted the fibrillation (Mirsadeghi et al, 2016). By applying thioflavin-T fluorescence emission, the effect of SPIONs with different electric charges on both β-amyloid and α-synuclein fibrillation process was investigated.…”

Section: Application Of Iron Oxide Nanoparticles In the Treatment Of Admentioning

confidence: 99%

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Application of Iron Oxide Nanoparticles in the Diagnosis and Treatment of Neurodegenerative Diseases With Emphasis on Alzheimer’s Disease

Luo

Zhu

et al. 2020

Front. Cell. Neurosci.

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Section: Application Of Iron Oxide Nanoparticles In the Treatment Of Adsupporting

confidence: 88%

Section: Application Of Iron Oxide Nanoparticles In the Treatment Of Admentioning

confidence: 99%

Application of Iron Oxide Nanoparticles in the Diagnosis and Treatment of Neurodegenerative Diseases With Emphasis on Alzheimer’s Disease

Luo

Zhu

et al. 2020

Front. Cell. Neurosci.

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“…Many compounds such as polyphenols, various drugs, flavonoids, vitamins and some metal complexes are known to inhibit the aggregation process of proteins either in vitro or in vivo 9 10 11 12 . Recently numbers of reports are available advocating the anti-aggregation effect of nanomaterial’s 13 14 15 16 . Varieties of vitamins including vitamin A, vitamin E, vitamin D and vitamin k attenuated the aggregation process in proteins and also delayed the onset of dementia 17 18 19 20 21 .…”

mentioning

confidence: 99%

Vitamin k3 inhibits protein aggregation: Implication in the treatment of amyloid diseases

Alam

Chaturvedi

Siddiqi

et al. 2016

Sci Rep

162

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Protein misfolding and aggregation have been associated with several human diseases such as Alzheimer’s, Parkinson’s and familial amyloid polyneuropathy etc. In this study, anti-fibrillation activity of vitamin k3 and its effect on the kinetics of amyloid formation of hen egg white lysozyme (HEWL) and Aβ-42 peptide were investigated. Here, in combination with Thioflavin T (ThT) fluorescence assay, circular dichroism (CD), transmission electron microscopy and cell cytotoxicity assay, we demonstrated that vitamin k3 significantly inhibits fibril formation as well as the inhibitory effect is dose dependent manner. Our experimental studies inferred that vitamin k3 exert its neuro protective effect against amyloid induced cytotoxicity through concerted pathway, modifying the aggregation formation towards formation of nontoxic aggregates. Molecular docking demonstrated that vitamin k3 mediated inhibition of HEWL and Aβ-42 fibrillogenesis may be initiated by interacting with proteolytic resistant and aggregation prone regions respectively. This work would provide an insight into the mechanism of protein aggregation inhibition by vitamin k3; pave the way for discovery of other small molecules that may exert similar effect against amyloid formation and its associated neurodegenerative diseases.

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“…Superparamagnetic iron oxide nanoparticles (SPIONs) were investigated as a brain Aβ1-40 fibril imaging, that showed a great increase in its fluorescence signal, which could lead to the successful imaging of these fibrils [10]. In fact, SPIONs recently also showed to affect the Aβ fibrillation process, thus providing a possible theragnostics platform [11].…”

Section: Introductionmentioning

confidence: 99%

Immunosensor for diagnosis of Alzheimer disease using amyloid-β 1–40 peptide and silk fibroin thin films

Gonçalves

Lima

Moraes

et al. 2016

Materials Science and Engineering: C

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Layer-by-Layer (LbL) films containing silk fibroin (SF) and the 40 aminoacid-long amyloid-β peptide (Aβ1-40) were prepared with the purpose of developing a new prototype of an electrochemical immunosensor. The film showed a satisfactory growth in quartz substrate and screen-printed carbon electrodes, as observed by UV-vis spectroscopy and cyclic voltammetric, respectively. The peptide immobilized in LbL films in junction with SF shows secondary structure induced, as shown by circular dichroism measurements, favoring the interaction SF/peptide LbL film with the specific antibody. Immunosensor showed a linear response in the presence of the antibody with concentrations from 0 to 10ngmL(-1) both analyzed by current changes in 0.3V and voltammogram area. This system can be applied as a new prototype for preliminary diagnosis of Alzheimer's disease.

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Effect of PEGylated superparamagnetic iron oxide nanoparticles (SPIONs) under magnetic field on amyloid beta fibrillation process

Cited by 59 publications

References 47 publications

Application of Iron Oxide Nanoparticles in the Diagnosis and Treatment of Neurodegenerative Diseases With Emphasis on Alzheimer’s Disease

Application of Iron Oxide Nanoparticles in the Diagnosis and Treatment of Neurodegenerative Diseases With Emphasis on Alzheimer’s Disease

Vitamin k3 inhibits protein aggregation: Implication in the treatment of amyloid diseases

Immunosensor for diagnosis of Alzheimer disease using amyloid-β 1–40 peptide and silk fibroin thin films

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