Effect of Penetration Enhancers on the Permeability of Ketoconazole Gels Through Rabbit Skin

Abstract

cellulose (NaCMC) and carbopol 934 gel formulations was investigated. Skin permeation studies were performed using Franztype diffusion cells and full-thickness abdominal rabbit skin. Various types of compounds such as oleic acid (OA), menthol (M) and isopropyl myristate (IPM) in various concentrations were employed as penetration enhancers. The steady-state flux, permeability coefficients, and enhancement ratios ER flux of KC for each formulation were calculated.The results showed that the skin permeability of KC from gels tested was significantly increased (P< 0.05) by 10% w/w OA, 5% w/w M and 5% w/w IPM.