Effect of penicillin-based antibiotics, amoxicillin, ampicillin, and piperacillin, on drug-metabolizing activities of human hepatic cytochromes P450

Niwa, Toshiyuki; Morimoto, Mari; Hirai, Takako; Hata, Tomomi; Hayashi, Misato; Imagawa, Yurie

doi:10.2131/jts.41.143

Cited by 25 publications

(14 citation statements)

References 14 publications

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“…For example, azithromycin has a negligible effect on CYP3A4 (i.e., it does not inhibit CYP3A4 or increase blood concentrations of CYP3A4-metabolized statins) and could be given to patients receiving CDK4/6 inhibitors in place of clarithromycin [31] (Table 3). Finally, it should be noted that breast cancer patients treated with CDK4/6 inhibitors have a very low risk to develop febrile neutropenia and, anti-pseudomonas βlactam agents, i.e., drugs proven not interacting with CYP3A4-metabolized substrates [34], are the first choice treatment for high-risk patients who require hospitalization for intravenous antibiotic therapy [32], in those uncommon cases of febrile neutropenia and risk of septic shock.…”

Section: Cyp3a4-based Ddismentioning

confidence: 99%

Drug-drug interactions in breast cancer patients treated with CDK4/6 inhibitors

Fogli

Curigliano

et al. 2019

Cancer Treatment Reviews

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CDK4/6 inhibitors are a new class of anticancer drugs used for the treatment of women with hormone receptorpositive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer with disease progression following endocrine therapy. Polypharmacy is a well-known problem in advanced cancer causing potential drug-drug interactions (DDIs), which, in turn, may limit the therapeutic value of CDK4/6 inhibitors. Therefore, understanding the mechanisms underlying potential DDIs in patients taking CDK4/6 inhibitors may be useful in decision-making processes and represent an important step towards treatment personalization. The present review is aimed at describing the potential DDIs that might occur in breast cancer patients receiving CDK4/6 inhibitors based on direct evidence from the literature and mechanistic considerations tailored on specific class of drugs used in combination.

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Section: Cyp3a4-based Ddismentioning

confidence: 99%

Drug-drug interactions in breast cancer patients treated with CDK4/6 inhibitors

Fogli

Curigliano

et al. 2019

Cancer Treatment Reviews

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“…Although both chronic alcohol consumption and amoxicillin + clavulanic acid therapy have been reported to exert liver injury, information about their CYP2C9 inhibitory potential is hardly available. In contrast to amlodipine and tamoxifen that have the capability to inhibit CYP2C9 function, chronic alcohol consumption and amoxicillin + clavulanic acid therapy evoking liver injury were likely to have non-specific impact on CYP enzyme function rather than direct CYP2C9 inhibitory properties 66 , 67 .…”

Section: Discussionmentioning

confidence: 99%

Impact of genetic and non-genetic factors on hepatic CYP2C9 expression and activity in Hungarian subjects

Fekete

Mangó

Déri

et al. 2021

Sci Rep

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CYP2C9, one of the most abundant hepatic cytochrome P450 enzymes, is involved in metabolism of 15–20% of clinically important drugs (warfarin, sulfonylureas, phenytoin, non-steroid anti-inflammatory drugs). To avoid adverse events and/or impaired drug-response, CYP2C9 pharmacogenetic testing is recommended. The impact of CYP2C9 polymorphic alleles (CYP2C9*2, CYP2C9*3) and phenoconverting non-genetic factors on CYP2C9 function and expression was investigated in liver tissues from Caucasian subjects (N = 164). The presence of CYP2C9*3 allele was associated with CYP2C9 functional impairment, and CYP2C9*2 influenced tolbutamide 4′-hydroxylase activity only in subjects with two polymorphic alleles, whereas the contribution of CYP2C8*3 was not confirmed. In addition to CYP2C9 genetic polymorphisms, non-genetic factors (co-medication with CYP2C9-specific inhibitors/inducers and non-specific factors including amoxicillin + clavulanic acid therapy or chronic alcohol consumption) contributed to the prediction of hepatic CYP2C9 activity; however, a CYP2C9 genotype–phenotype mismatch still existed in 32.6% of the subjects. Substantial variability in CYP2C9 mRNA levels, irrespective of CYP2C9 genotype, was demonstrated; however, CYP2C9 induction and non-specific non-genetic factors potentially resulting in liver injury appeared to modify CYP2C9 expression. In conclusion, complex implementation of CYP2C9 genotype and non-genetic factors for the most accurate estimation of hepatic CYP2C9 activity may improve efficiency and safety of medication with CYP2C9 substrate drugs in clinical practice.

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“…Hence, the bacterial cell wall synthesis will be interrupted. The bacterial cell wall will be weakened leading to cell lysis [51]. This result suggests imipenem as the most efficient antibiotics against pathogens isolated from braised products sold in the city of Bangangte.…”

Section: Antibiotic Resistance Profile Of Strains Isolated From Braised Products Sold the City Of Bangangtementioning

confidence: 99%

Assessment of the Microbial Quality of Braised Products from Bangangte City and Antibiotic Susceptibility of Selected Pathogens Isolated Therein

Pahane

Mouafo²,

Noumo

et al. 2021

AJB2T

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The present study had as objective to assess the microbiological quality and profile of some braised products and their accompanying soups sold in the city of Bangangte (Cameroon) and evaluate the antibiotic susceptibility of selected pathogens isolated in these products. An investigation was conducted in three locations in city of Bangangte in order to assess the environment and working conditions as well as the respect of good hygiene practices. Then, samples of braised fish (05) and its soups (05), and braised chicken (05) and its soups (05) were collected from six vendors in each location. The samples (360) were submitted to microbiological analyses and the isolates were identified at species level using API gallery. The susceptibility of the isolates to 14 antibiotics were tested. The 72 participants involved in this study declared having knowledge on hygiene despite the fact that, most of them had no formal education and do not apply good hygiene practices. Microbiological analyses revealed the poor quality of all the samples of braised products. Fecal coliforms and staphylococci counts higher than the values recommended by norms demonstrated the non-respect of good hygiene and manufacturing practices during the braising activity. The 169 strains isolated from these products belonged to 12 different species: Enterobacter gergoviae, Enterobacter spp., Morganella morganiae, Yersinia enterolitica, Yersinia frederiksenii, Staphylococcus aureus, Staphylococcus epidermitidis, Staphylococcus spp., Clostridium spp., Klebsiella pneumoniae, Enterobacter aerogene, and Proteus mirabilis. Strains which could be considered as marker of braised fish sold in the city of Bangangte were Yersinia enterolitica, Staphylococcus aureus and Klebsiella pneumonia while for braised chicken, they were Yersinia enterolitica, Staphylococcus aureus and Proteus mirabilis. The antibiotic susceptibility test performed on these pathogens revealed that they were resistant with 93.75% having multiple antibiotic resistance index values greater than 0.2. We conclude that the microbiological quality of braised products is poor and we suggest to producers to applicate the good hygiene practices. For breeders, we suggest respecting withdrawal periods and the better use of antibiotics.

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Effect of penicillin-based antibiotics, amoxicillin, ampicillin, and piperacillin, on drug-metabolizing activities of human hepatic cytochromes P450

Cited by 25 publications

References 14 publications

Drug-drug interactions in breast cancer patients treated with CDK4/6 inhibitors

Drug-drug interactions in breast cancer patients treated with CDK4/6 inhibitors

Impact of genetic and non-genetic factors on hepatic CYP2C9 expression and activity in Hungarian subjects

Assessment of the Microbial Quality of Braised Products from Bangangte City and Antibiotic Susceptibility of Selected Pathogens Isolated Therein

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