Effect of pentobarbital anesthesia on renal sympathetic nerve activity in the rabbit

Morita, Hironobu; Nishida, Yasuhiro; Uemura, Nobuhisa; Hara, Hiroshi

doi:10.1016/0165-1838(87)90081-6

Cited by 49 publications

(24 citation statements)

References 16 publications

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“…NINOMIYA et al These central rhythms were studied under various states in anesthetized animals. Tonic and reflex renal sympathetic nerve activity was influenced by anesthesia (MORITA et al, 1987;MATSUKAWA and NINOMIYA, 1989), and therefore influences of anesthesia on central rhythms could not be neglected.…”

mentioning

confidence: 99%

Fundamental rhythm of cardiac sympathetic nerve activity in awake cats at rest and during body movement.

Ninomiya¹,

Nishiura²,

Matsukawa³

et al. 1989

Jpn.J.Physiol

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Cardiac sympathetic nerve activity (CSNA in imp/s) was measured in the postganglionic fibers of awake cats at rest, during body movement, and with excitement. The CSNA showed synchronized discharges with various periodicities. Rhythms of the synchronized CSNA were analyzed by an interval histogram (IIH). The IIH showed a multimodal distribution. The first model interval (Ta) was in a range of 75 to 125 ms. An 8-12 cycle/s T~ rhythm, i.e., inverse value of T~, was always observed in the awake cat at rest and during body movements.

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mentioning

confidence: 99%

Fundamental rhythm of cardiac sympathetic nerve activity in awake cats at rest and during body movement.

Ninomiya¹,

Nishiura²,

Matsukawa³

et al. 1989

Jpn.J.Physiol

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“…The effects of pentobarbital sodium on the cardiovascular regulatory system have been studied to investigate the mechanism of circulatory action of the anesthetics. Pentobarbital sodium has been shown to have the suppressing effects on the sympathetic [5,16,21,22] or parasympathetic nervous system [5,19], which involved the reduction in baroreflex function. The effect of pentobarbital sodium on the baroreflex system has often been evaluated with AP or HR responses to cardiovascular stimulus, e.g., hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

“…The control capacity of the baroreflex AP control system progressively decreased with time after massive hemorrhage and tended to recover somewhat by 110 min after hemorrhage. Therefore, the evaluation of the baroreflex AP control capacity under the hypovolemic conditions due to massive hemorrhage, including estimation of time-dependent effects of anesthetics, is not considered to show the precise control capacity of the system because massive hemorrhage must be a parametric forcing which modifies the normal characteristics of the baroreflex AP control system [6][7][8][9][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

“…It is known that pentobarbital anesthesia can affect cardiovascular function, whereas it decreased fluctuation in cardiovascular parameters i.e., arterial pressure (AP) and heart rate (HR), and so forth, establishing stable experimental conditions. Pentobarbital anesthesia has been indicated to play a major part in the autonomic nervous system [3,5,16,19,21,22], which is responsible for modifying the sensitivity of baroreflex AP or HR control [1,2,8,16]. Zimpfer, et al [24] reported that pentobarbital sodium reduced the capacity to restore hypotension due to hemorrhage.…”

Section: Introductionmentioning

confidence: 99%

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Time-Dependent Change in Baroreflex Control Capacity of Arterial Pressure by Pentobarbital Anesthesia in Rabbits.

et al. 2000

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Abstract:The present study is designed to investigate the time-dependent effect of pentobarbital anesthesia on the baroreflex arterial pressure (AP) control system in rabbits. The overall AP control capacity of the baroreflex system was assessed with mean arterial pressure (MAP) responses to the rapid mild hemorrhage (2 ml/kg body weight) and an overall open-loop gain (G) of the system. The G value was determined by means of the following formula: G=∆AP I /∆AP S -1, where ∆AP I is an immediate MAP fall and ∆AP S a steady-state fall after the rapid hemorrhage. Prior to the experiment, two catheters for AP measurement and hemorrhage were chronically in-dwelt in the aortic arch via the left subclavian and left common carotid arteries, respectively. Control mean arterial pressure averaged for 30 sec before the rapid hemorrhage (CMAP), ∆AP I and ∆AP S significantly increased and reached the maximal value at 14 min (CAMP: p<0.01) and 28 min (∆AP I : p<0.01 and ∆AP S : p<0.01) after the intravenous injection of sodium pentobarbital in a 25.0 mg/kg dose, respectively. These values gradually decreased in the course of time and tended to recover to near the preanesthetic level at 77-98 min after the anesthesia. The G value significantly decreased from 7.3 in the conscious state to 1.5 at 28 min after the anesthesia (p<0.001), gradually increased with lapse of time and recovered to near the preanesthetic level at 77-98 min after the anesthesia. No significant difference in G was observed between in the conscious and anesthetized states beyond 70 min after the anesthesia (p>0.05). These findings suggest that pentobarbital sodium exerts a timedependent inhibitory effect on the baroreflex system but does not significantly affect the overall AP control capacity of the baroreflex system itself at least 70 min after the intravenous administration at a dose of 25.0 mg/kg.

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“…These controversial results were probably due to species difference and anesthetics. It should be noted that pentobarbital anesthesia decreased RNA in SAD rabbits and also decreased the sensitivity of RNA (MORITA et a!., 1987). Thus, responses of RNA to ANP infusion is best studied in chronically instrumented conscious animals.…”

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confidence: 99%

Renal nerve blunts natriuretic and diuretic response to atrial natriuretic peptide in conscious rabbits.

et al. 1989

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The contribution of the renal nerve to the natriuretic and diuretic responses to rat atrial natriuretic peptide (rAMP) was investigated in conscious rabbits with unilateral renal denervation. Renal nerve activity (RNA) was measured at the contralateral innervated kidney. Catheters were bilaterally implanted into the ureters. Urine samples were collected from each kidney by gravity drainage at 10-min clearance intervals. In rabbits with all baroreflexes intact, infusion of rANP at 0.3 tg/(kg . min) for 30 min decreased mean arterial pressure by 8±4 mmHg and increased RNA by 53 + 13%. After sinoaortic baroreceptor denervation (SAD), hypotensive response to infusion of rANP was greater than that in intact rabbits, while RNA did not change. After SAD plus vagotomy, infusion of rANP lowered mean arterial pressure by 21 + 4 mmHg and RNA by 19 + 6%. In the denervated kidney, infusion of rANP increased Na+ excretion by 16.1 + 4.5 from 3.5 + 1.0 , tEq/min and water excretion by 0.17 + 0.05 from 0.08 + 0.02 ml/min. In the contralateral innervated kidney, infusion of rANP increased the amount of Na+ and water excretion by 4.5 + 3.2 µEq/min and 0.07 + 0.04 ml/min, which were significantly less than those in the denervated kidney. These results indicate that infusion of rANP increases RNA, due to baroreceptor reflexes, and that this increase in RNA blunts natriuretic and diuretic action of rANP.

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Effect of pentobarbital anesthesia on renal sympathetic nerve activity in the rabbit

Cited by 49 publications

References 16 publications

Fundamental rhythm of cardiac sympathetic nerve activity in awake cats at rest and during body movement.

Fundamental rhythm of cardiac sympathetic nerve activity in awake cats at rest and during body movement.

Time-Dependent Change in Baroreflex Control Capacity of Arterial Pressure by Pentobarbital Anesthesia in Rabbits.

Renal nerve blunts natriuretic and diuretic response to atrial natriuretic peptide in conscious rabbits.

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