Effect of pentoxifylline on semen parameters, reproductive hormones, and seminal plasma antioxidant capacity in men with idiopathic infertility: a randomized double-blind placebo-controlled study

Safarinejad, Mohammad Reza

doi:10.1007/s11255-010-9826-4

Cited by 60 publications

(50 citation statements)

References 51 publications

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“…Previous studies indicated that pentoxifylline improved all sperm parameters including sperm count, motility and morphology the serum level of LH, FSH and also testosterone in idiopathic infertile and also in asthenozoospermic men (22). The present study added that pentoxifylline increased serum level of LH, FSH and testosterone in morphine abused animals.…”

Section: Discussionsupporting

confidence: 68%

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Moradi¹,

Mahmoodi²,

Raoofi³

et al. 2015

BLL

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Abstract:Background: Knowledge about harmful effects of morphine on hormone secretion seems to be necessary. The aim of the present study was to evaluate the effect of pentoxifylline on side effects derived by morphine on hypophyso-gonadal hormones of male rats. Methods: 32 male rats were divided into the 4 groups of OSS: control (received 40 g Sucrose/l drinking water and intraperitoneal injection of 1 l/kg normal saline), OMS: morphine group (received 0.4 mg/l + 40 g Sucrose/l in drinking water and intraperitoneal injection of 1 l/kg normal saline), NMS: morphine+naltrexane group (received 0.4 mg/l + 40 g Sucrose/l in drinking water and IP injection dose of 10 mg/kg/ml/day Naltrexane) and PMS: morphine + pentoxifylline group (received 0.4 mg/dl + 40 g Sucrose/l in drinking water and IP injection dose of 12 mg/kg/ml/day Pentoxifylline) for 56 days, respectively. Results: Serum levels of testosterone, LH, FSH hormones were measured. Pentoxifylline increased serum levels of testosterone, LH, FSH hormones compared to control, morphine and morphine-naltrexane groups. Conclusion: Pentoxifylline has a signifi cant effi cacy for increasing serum levels of sexual hormones. Considering that Pentoxifylline is safe and cheap, with easy application, we suggest for the usage of this drug for improving semen parameter's quality before performing ART for the treatment of morphine addicts (Fig. 1, Ref. 31). Text in PDF www.elis.sk.

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Section: Discussionsupporting

confidence: 68%

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Moradi¹,

Mahmoodi²,

Raoofi³

et al. 2015

BLL

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“…Although WHO reference values from 2010 define teratozoospermia as less than 4% of normal shape and form spermatozoa [51] strict Krüger criteria are still used as reference value for assessing sperm morphology. L-carnitine in combination with CoQ10, vitamins E and C, zinc, selenium [20, 40], CoQ10 alone [23, 24], pentoxifylline [25], N-acetyl-cysteine with Se [27], vitamin C alone [28], combination of papaya, beta-glucan, lactoferrin, vitamins C and E [36], Se, and vitamin E [38], and pycnogenol [41] significantly improved sperm morphology. Therapy with 200 mg CoQ10 daily for 26 weeks improved sperm morphology in 114 participants in study group to 17.6% ± 4.4% versus 14.8% ± 4.1% in 114 participants in placebo group ( P = 0.01) [23].…”

Section: Resultsmentioning

confidence: 99%

Review of Clinical Trials on Effects of Oral Antioxidants on Basic Semen and Other Parameters in Idiopathic Oligoasthenoteratozoospermia

Kumalic

Pinter

2014

BioMed Research International

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Infertility affects 50 to 80 million people worldwide. Male factor is a cause of infertility in almost half of cases, mainly due to oligoasthenoteratozoospermia (OAT). With common diagnostic methods no cause can be found in approximately 30% of cases of male infertility due to OAT and these are considered idiopathic. Reactive oxygen species (ROS) play an important role in male infertility and are proved to be higher in infertile men; antioxidants could oppose their effect. The aim of this paper was to review the literature on clinical trials in the period from year 2000 to year 2013 studying the effects of various types of antioxidant supplements on basic and other sperm parameters and pregnancy rates in subfertile males with idiopathic OAT. The majority of studies were randomized and placebo controlled and confirmed beneficial effect of antioxidants on at least one of the semen parameters; the biggest effect was determined on sperm motility. In many of these trials combinations of more antioxidants were assessed. The optimal dosages of one or more antioxidants were not defined. We concluded that antioxidants play an important role in protecting semen from ROS and can improve basic sperm parameters in case of idiopathic OAT.

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“…Infertile men have higher mean AA/DHA ratio and AA/EPA ratio than fertile men. 14 Also, other supplements with anti-oxidant activities such as selenium, 17 coenzyme Q 10 , 18 and pentoxifylline 19 have demonstrated favorable efficacy in infertile men with …”

mentioning

confidence: 99%

“…Infertile men have higher mean AA/DHA ratio and AA/EPA ratio than fertile men. 14 Also, other supplements with anti-oxidant activities such as selenium, 17 coenzyme Q 10 , 18 and pentoxifylline 19 idiopathic OAT. Recently supplementation with omega-3 PUFAs has received great attention in the course of psychiatric, neurologic and cardiovascular diseases.…”

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confidence: 99%

The roles of omega-3 and omega-6 fatty acids in idiopathic male infertility

Safarinejad¹,

Safarinejad²

2012

Asian J Androl

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mega-3 fatty acids found in some foods have a wide-range of health benefits. The omega-3 supplementation results in higher antioxidant activity in human seminal fluid and enhanced sperm count, sperm motility, and sperm morphology. Considerable number of infertile men with idiopathic oligoasthenoteratozoospermia might be benefit from omega-3 fatty acids administration.Infertility caused by idiopathic oligoasthenoteratozoospermia(OAT) syndrome without any female factor represents one of the biggest patients group in the daily practice of urologists. Despite great advances in the field of infertility, still many cases of male infertility are diagnosed as idiopathic and remained untreated. In low-income communities where health service resources are restricted and basic health needs are unmet, health resources are not used to provide expensive technologies for the treatment of infertility. Social and family consequences of infertility, especially in developing and under developed communities are devastating. A decrease in male fertility has been occurred over the years. 1 Sperm density had fallen by 40% over the past 50 years. 2 One of the reasons for the impaired semen parameters over the years is dietary factors. 3,4 The significant effects of dietary fatty acids (FAs) on male fertility have been well documented both in animal and human studies. 5,6 There are three types of natural FAs: saturated, monounsaturated and polyunsaturated. Polyunsaturated fatty acids (PUFAs) are essential FAs, because they cannot be synthesized by the human body. Docosahexanoic acid (DHA), eicosapentanoic acid (EPA) and alinolenic acid are the main omega-3 PUFAs.Linoleic acid, c-linolenic acid and arachidonic acid (AA) are the main omega-6 PUFAs. The first mechanism by which omega-3 and omega-6 PUFAs affect spermatogenesis, is by the incorporation into spermatozoa cell membrane. Omega-3 and omega-6 PUFAs are structural components of cell membranes. 7 The lipid bilayer of cellular membranes is maintained by the presence of these PUFAs. 8 The successful fertilization of spermatozoa depends on the lipids of the spermatozoa membrane. 9 Deleterious health effects of increased dietary omega-6/omega-3 ratios have been documented in many studies. 10 The ideal ratio is 1:1. During the past 100 years, omega-6 PUFAs of Western diets have increased dramatically. This has resulted in an omega-6/omega-3 ratio of 25:1 to 40:1. 11 Increased omega-6/omega-3 ratio in spermatozoa has also been implicated in impaired semen quality in oligozoospermic and/or asthenozoospermic men. 12 Spermatozoa from asthenozoospermic and oligozoospermic men exhibit decreased concentrations of DHA compared with those from normozoospermic men. Conquer et al. 13 demonstrated that, compared with normozoospermic men, spermatozoa from asthenozoospermic men have diminished concentrations of DHA and higher concentrations of oleic acid. Safarinejad et al., 14 investigated PUFA composition of the blood plasma and spermatozoa in men with idiopathic OAT. They found that, fertile men h...

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Effect of pentoxifylline on semen parameters, reproductive hormones, and seminal plasma antioxidant capacity in men with idiopathic infertility: a randomized double-blind placebo-controlled study

Abstract: PTX administration significantly improves semen parameters in infertile men with idiopathic OAT.

Cited by 60 publications

References 51 publications

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Review of Clinical Trials on Effects of Oral Antioxidants on Basic Semen and Other Parameters in Idiopathic Oligoasthenoteratozoospermia

The roles of omega-3 and omega-6 fatty acids in idiopathic male infertility

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