Effect of peptide Pro-Gly-Pro on stress-induced behavioral changes in rats

Therapeutic effects of glyprolines (PGP, GP, and PG) in rats with stress-induced behavioral disorders

“…Poststress (15 min after the end of swimming) intranasal administration of peptides Pro-Gly-Pro and GlyPro in a dose of 3.7 µmol/kg prevented stress-induced behavioral disorders. This effect persisted for 3 h.Short peptides containing glycine and proline (glyprolines) can cross the blood-brain barrier [3,4] and prevent stress-induced behavioral disorders in rats [1,2,6]. Peptides Pro-Gly-Pro (PGP) and Gly-Pro (GP) produce the most pronounced protective effects.…”

“…Short peptides containing glycine and proline (glyprolines) can cross the blood-brain barrier [3,4] and prevent stress-induced behavioral disorders in rats [1,2,6]. Peptides Pro-Gly-Pro (PGP) and Gly-Pro (GP) produce the most pronounced protective effects.…”

Protective and therapeutic effects of glyprolines in psychoemotional stress induced by cholecystokinin-4 injection

“…Short di-and tripeptides containing glycine and proline can cross the blood-brain barrier [3,4] and produce protective and therapeutic effects in behavioral disturbances caused by physical strain in rats [1,2,6].…”