Effect of pequi shell ethanolic extract on glutathione reductase activity in rats exposed to doxorubicin cardiotoxicity

Moura, Léa Resende; Almeida, Loanny Maria de; Neves, Raquel Emanuelle de Jesus; Viegas, Ângela Alves; Lima, Claudinei Sousa; Moura, Veridiana Maria Brianezi Dignani de

doi:10.29374/2527-2179.bjvm89019

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…However, it has side effects, such as cardiotoxicity exerted through the production of free radicals. In the study of Moura et al [16], ethanolic extract of pequi bark (PSEE) was administered daily to DOX-treated rats; this led to increased activity of the enzyme glutathione reductase (GDH-Rd). This enzyme is responsible for maintaining the cellular protection system intact through a biochemical cascade.…”

Section: Biological Activitiesmentioning

confidence: 99%

Brazilian Amazon Plants: An Overview of Chemical Composition and Biological Activity

Cunha¹,

Domingues²,

Ambrósio³

et al. 2021

Natural Resources Management and Biological Sciences

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Currently, the number of diseases has been increasing and reaching the population directly, and the deliberate use of drugs is creating resistance of pathogens in several drugs, a fact evidenced by the increased ineffectiveness of drugs and the persistence of infections in the body. Given this, it is necessary to search for new alternative drugs that can effectively promote effective therapy. It is possible to highlight, in Brazil, the diversity of the Amazonian flora, which has several species with considerable potential as a source of new molecules with identified biological activity. Thus, a literature review study was conducted in order to describe the applications of some Amazonian extracts and their chemical characteristics and biological activity. The Amazon rain forest has considerable diversity of plant species with biological properties that may be useful to public health. Further research is needed to identify new compounds with health benefits.

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Section: Biological Activitiesmentioning

confidence: 99%

Brazilian Amazon Plants: An Overview of Chemical Composition and Biological Activity

Cunha¹,

Domingues²,

Ambrósio³

et al. 2021

Natural Resources Management and Biological Sciences

View full text Add to dashboard Cite

show abstract

Preventive aerobic training preserves sympathovagal function and improves DNA repair capacity of peripheral blood mononuclear cells in rats with cardiomyopathy

Ghignatti

Russo

Becker

et al. 2022

Sci Rep

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To evaluate the effect of preventive aerobic exercise training on sympathovagal function, cardiac function, and DNA repair capacity in a preclinical model of doxorubicin (DOX)-induced cardiomyopathy. Forty male Wistar-Kyoto rats were allocated into four groups (n = 10/group): D (DOX-treated) and C (controls) remained sedentary, and DT (DOX-trained) and CT (control-trained) performed aerobic training 4 days/week, during 4 weeks before exposure to DOX (4 mg/kg/week during 4 weeks) or saline solution. We evaluated cardiac function (echocardiography), hemodynamic and sympathovagal modulation (artery-femoral cannulation), cardiac troponin T levels, and DNA repair capacity (comet assay). Exercise training preserved ejection fraction (D: − 14.44% vs. DT: − 1.05%, p < 0.001), fractional shortening (D: − 8.96% vs. DT: − 0.27%, p = 0.025) and troponin T levels (D: 6.4 ± 3.6 vs. DT: 2.8 ± 1.7 ng/mL, p = 0.010). DOX increased heart rate variability (C: 27.7 ± 7.9 vs. D: 7.5 ± 2.2 ms2, p < 0.001) and induced sympathovagal dysfunction (LF/HF, C: 0.37 ± 0.15 vs. D: 0.15 ± 0.15, p = 0.036) through exacerbation of sympathetic function (LF, C: 0.22 ± 0.01 vs. D: 0.48 ± 0.24 Hz, p = 0.019). Peripheral mononuclear blood cells of DT animals presented lower residual DNA damage (D: 43.4 ± 8.4% vs. DT: 26 ± 3.4%, p = 0.003 after 1 h). Cardioprotective effects of preventive aerobic exercise training are mediated by preservation of sympathovagal function and improvement of DNA repair capacity of peripheral blood mononuclear cells.

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Effect of pequi shell ethanolic extract on glutathione reductase activity in rats exposed to doxorubicin cardiotoxicity

Cited by 2 publications

References 15 publications

Brazilian Amazon Plants: An Overview of Chemical Composition and Biological Activity

Brazilian Amazon Plants: An Overview of Chemical Composition and Biological Activity

Preventive aerobic training preserves sympathovagal function and improves DNA repair capacity of peripheral blood mononuclear cells in rats with cardiomyopathy

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