Effect of Percutaneous Coronary Intervention on Left Ventricular Diastolic Function in Patients With Coronary Artery Disease

Salehi, Nahid; Saidi, Mohammadreza; Rai, Alireza; Najafi, Fatemeh; Javeedannejad, Seedmokhtar; Babanejad, Mehran; Tadbiri, Hooman

doi:10.5539/gjhs.v8n1p270

Cited by 6 publications

(6 citation statements)

References 17 publications

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“…Moreover, the diagnosis of DHF is more difficult than that of SHF, which easily misses the optimal timing of early treatment for patients with DHF, resulting in poor prognosis or increased risk of death in patients with DHF [ 6 ]. At present, Doppler echocardiography is mostly used to evaluate left ventricular diastolic function for the diagnostic methods of DHF, and the main indicators include mitral annular velocity (Ea) and mitral valve bleeding velocity ( E / A ) [ 7 ]. This method can clearly observe the cardiac structural function and judge the hemodynamics.…”

Section: Introductionmentioning

confidence: 99%

The Value of Echocardiography Combined with NT-pro BNP Level in Assessment and Prognosis of Diastolic Heart Failure

Chen

Zhou

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. To investigate the significance of echocardiography combined with N-terminal pro-B-type natriuretic peptide (NT-pro BNP) levels in the evaluation and prognosis of diastolic heart failure (DHF). Methods. Clinical data were collected from 168 patients with DHF. Serum levels of NT-pro BNP were first measured by ELISA. Meanwhile, the echocardiography was used to examine left ventricular end-diastolic diameter (LVEDD), left ventricular diameter (LVD), and other parameters. Multivariate logistic regression analysis was performed for variables in heart failure assessment grade or poor prognosis. Finally, the predictive ability for New York Heart Association (NYHA) class as well as prognosis was assessed by ROC curves. Results. NT-pro BNP was the overexpression in the serum of patients with DHF. And the degree of elevation was related to NYHA class, while NT-pro BNP levels were significantly higher in the P-MACE group than in the N-MACE group. According to the multivariate logistic regression analysis, the ratio of peak velocity of left atrial early diastolic blood flow to early diastolic peak velocity of mitral annulus ( E /Ea) and serum NT-pro BNP level was risk factors for NYHA class and prognosis. However, LVEF, LVEDD, and flow propagation velocity (Vp) can be a benefit condition. In addition, ROC curve showed that echocardiography combined with NT-pro BNP content had higher accuracy in NYHA class and prognostic assessment of DHF than applied separately. Conclusions. The diagnosis of echocardiography combined with NT-pro BNP levels has the potential to distinguish the NYHA class in heart function of patients with DHF and determine the prognosis of patients.

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Section: Introductionmentioning

confidence: 99%

The Value of Echocardiography Combined with NT-pro BNP Level in Assessment and Prognosis of Diastolic Heart Failure

Chen

Zhou

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Previous studies have done some comparison on LVEF for patients undergoing PCI using echocardiography before, 1 day after and 3-6 months after the procedure. It was found that LVEF improved signi cantly at 1 day and 3-6 months after the procedure, whereas diastolic function improved at 1 day but did not change 3-6 months after the procedure [25]. Other studies have shown that LV diastolic function is altered after PCI [26-28].…”

Section: Discussionmentioning

confidence: 94%

The constricting effect of reduced coronary artery compliance on the left ventricle is an important cause of reduced diastolic function in patients with coronary heart disease

Zhang

et al. 2022

Preprint

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Background: Previous studies of left ventricular diastolic function (LVDF) have focused on the decrease in active and passive diastolic function due to ischemic factors but have not investigated if the decrease in compliance of the coronary arteries that bypass the surface of the heart and travel between the myocardium could cause a constricting effect on the ventricular wall like that caused by myocardial fibrosis.Methods and Results: From October 2016 to October 2019, the Department of Cardiology of Fengxian District Central Hospital treated 581 patients diagnosed with coronary heart disease (CHD). They were divided into groups according to the degree of coronary stenosis, the number of stents and the length of stents implanted. It was concluded that there was a statistical difference in Gensini scores between patients in groups B, C and D (P<0.001). And multiple linear regression analysis showed that T was correlated with Gensini score and C-dp/dtmax(R=0.711, P<0.001). Grouping according to the site of stent implantation and the number of stents implanted, it was found out that the changes in T values before and after left anterior descending artery (LAD) stent implantation were greater than left circumflex artery (LCX) and right coronary artery (RCA) (P<0.001). And multiple linear regression revealed a correlation between T values and stent length, ventricular stiffness, and C-dp/dtmax(P=0.001). Conclusions: The decrease in compliance of the coronary arteries bypassing the surface of the heart and travelling between the myocardium would cause a constricting effect on the ventricular wall like that caused by myocardial fibrosis.

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“…Previous studies have done some comparison on LVEF for patients undergoing PCI using echocardiography before, 1 day after and 3–6 months after the procedure. It was found that LVEF improved significantly at 1 day and 3–6 months after the procedure, whereas diastolic function improved at 1 day but did not change 3–6 months after the procedure [ 25 ]. Other studies have shown that LV diastolic function is altered after PCI [ 26 – 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…And patients with LAD stents were divided into normal and abnormal groups. The T values of both groups were analysed by ROC curves to determine the threshold length of the stent that could cause abnormal T values in LAD implanted stents 3-6 months after the procedure, whereas diastolic function improved at 1 day but did not change 3-6 months after the procedure [25]. Other studies have shown that LV diastolic function is altered after PCI [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

The constricting effect of reduced coronary artery compliance on the left ventricle is an important cause of reduced diastolic function in patients with coronary heart disease

et al. 2022

BMC Cardiovasc Disord

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Background Previous studies of left ventricular diastolic function (LVDF) have focused on the decrease in active and passive diastolic function due to ischemic factors but have not investigated if the decrease in compliance of the coronary arteries that bypass the surface of the heart and travel between the myocardium could cause a constricting effect on the ventricular wall like that caused by myocardial fibrosis. Methods and Results 581 patients diagnosed with coronary heart disease (CHD) were divided into A group (patients are the control group), B group (patients with less than 50% coronary artery stenosis), C group (patients with coronary artery stenosis between 50 and 75%), D group (patients with coronary artery stenosis greater than 75%) according to the degree of coronary stenosis. The diastolic function of the ventricle is reflected by applying the relaxation time constant T value, which refers to the time between peak dp/dt and end-diastolic pressure in the left ventricle. It was concluded that there was a statistical difference in Gensini scores between patients in groups B, C and D (P < 0.001). And multiple linear regression analysis showed that T was correlated with Gensini score and C-dp/dtmax (R = 0.711, P < 0.001). Grouping according to the site of stent implantation and the number of stents implanted, it was found out that the changes in T values before and after left anterior descending artery (LAD) stent implantation were greater than left circumflex artery (LCX) and right coronary artery (RCA) (P < 0.001). And multiple linear regression revealed a correlation between T values and stent length, ventricular stiffness, and C-dp/dtmax (P = 0.001). Conclusions The decrease in compliance of the coronary arteries bypassing the surface of the heart and travelling between the myocardium would cause a constricting effect on the ventricular wall like that caused by myocardial fibrosis.

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Effect of Percutaneous Coronary Intervention on Left Ventricular Diastolic Function in Patients With Coronary Artery Disease

Cited by 6 publications

References 17 publications

The Value of Echocardiography Combined with NT-pro BNP Level in Assessment and Prognosis of Diastolic Heart Failure

The Value of Echocardiography Combined with NT-pro BNP Level in Assessment and Prognosis of Diastolic Heart Failure

The constricting effect of reduced coronary artery compliance on the left ventricle is an important cause of reduced diastolic function in patients with coronary heart disease

The constricting effect of reduced coronary artery compliance on the left ventricle is an important cause of reduced diastolic function in patients with coronary heart disease

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