Effect of perinatally supplemented flavonoids on brain structure, circulation, cognition, and metabolism in C57BL/6J mice

Janssen, Carola I.F.; Zerbi, Valerio; Mutsaers, Martina P. C.; Jochems, Mieke; Vos, Claudia A.; Vos, Julle O.; Berg, Brian M.; Tol, Eric A.F. van; Gross, Gabriele; Jouni, Zeina E.; Heerschap, Arend; Kiliaan, Amanda J.

doi:10.1016/j.neuint.2015.05.002

Cited by 11 publications

(2 citation statements)

References 63 publications

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“…Polyphenols from plant-based foods are potent antioxidants that can cross the BBB ( 9 ) and ameliorate neuroinflammation by inhibiting proinflammatory markers such as IFN-γ, IL-6, NF-κB, and TNF-α ( 10 , 46 ). Polyphenols can also increase cerebral blood flow, induce hippocampal neurogenesis and plasticity ( 11 , 47 ), improve white-matter integrity and spatial learning, and increase locomotor activity in mice ( 48 ) and humans ( 47 ). Among the urine polyphenols, urolithin A and tyrosol elevations were associated with favorable brain anatomic changes.…”

Section: Discussionmentioning

confidence: 99%

The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)

Kaplan

Zelicha

Meir

et al. 2022

The American Journal of Clinical Nutrition

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Background The effect of diet on age-related brain atrophy is largely unproven. Objective To explore the effect of a Mediterranean diet higher in polyphenols and lower in red/processed meat (Green-MED diet) on age-related brain atrophy. Methods This 18-month clinical trial longitudinally measured brain structure volumes by magnetic-resonance-imaging using hippocampal-occupancy (HOC) and lateral-ventricle-volume (LVV) expansion scores as neurodegeneration markers. Abdominally obese/dyslipidemic participants were randomly assigned to (1)-healthy dietary guidelines (HDG), (2)-Mediterranean (MED) diet, or (3)-Green-MED diet (MED diet higher in polyphenols and lower in red/processed meat). All subjects received free gym memberships and physical activity guidance. Both MED groups consumed 28g/day walnuts (+440 mg/d polyphenols). The Green-MED group consumed green-tea (3-4 cups/day) and Mankai (Wolffia-globosa strain, 100g frozen-cubes/day) green shake (+800mg/day polyphenols). Results Among 284 participants (age = 51years; 88% men; BMI = 31.2kg/m2; apolipoprotein E-ε4 genotype = 15.7%), 224 (79%) completed the trial with eligible whole-brain MRIs. The pallidum (-4.2%), third ventricle (+3.9%), and LVV (+2.2%) disclosed the largest volume changes. Compared to younger participants, atrophy was accelerated among those ≥ 50 years [HOC change = -1.0±1.4% vs. -0.06±1.1%; 95% confidence-interval (CI):0.6, 1.3; p<0.001; LVV change = 3.2±4.5% vs. 1.3±4.1%; 95%CI:-3.1, -0.8;p = 0.001]. In subjects ≥50years, HOC decline and LVV expansion were attenuated in both MED groups, with the best outcomes among Green-MED diet participants, as compared to HDG (HOC: -0.8±1.6% vs. -1.3±1.4%;95%CI: -1.5, -0.02;p = 0.042, LVV: 2.3±4.7% vs. 4.3±4.5;95%CI;0.3, 5.2;p = 0.021). Similar patterns were observed among younger subjects. Improved insulin sensitivity over the trial was the strongest parameter associated with brain atrophy attenuation (p<0.05). Greater Mankai, green-tea and walnuts intake and less red and processed meat were significantly and independently associated with reduced HOC decline (p<0.05). Elevated urinary levels of the Mankai-derived polyphenols: urolithin-A (r = 0.24;p = 0.013) and tyrosol (r = 0.26;p = 0.007) were significantly associated with lower HOC decline. Conclusions A Green-MED, high-polyphenol diet, rich in Mankai, green tea and walnuts and low in red/processed meat is potentially neuroprotective for age-related brain atrophy.

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Section: Discussionmentioning

confidence: 99%

The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)

Kaplan

Zelicha

Meir

et al. 2022

The American Journal of Clinical Nutrition

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“…Locomotion and explorative behavior were evaluated for 10 minutes in the open field prior to the tMCAo, and also 3 and 23 days poststroke as previously described 52 - 55 . Using EthoVision XT10.1 (Noldus, Wageningen, The Netherlands), locomotion was automatically recorded.…”

Section: Methodsmentioning

confidence: 99%

A specific dietary intervention to restore brain structure and function after ischemic stroke

Wiesmann¹,

Zinnhardt²,

Reinhardt³

et al. 2017

Theranostics

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Occlusion of the middle cerebral artery (MCAo) is among the most common causes of ischemic stroke in humans. Cerebral ischemia leads to brain lesions existing of an irreversibly injured core and an ischemic boundary zone, the penumbra, containing damaged but potentially salvageable tissue. Using a transient occlusion (30 min) of the middle cerebral artery (tMCAo) mouse model in this cross-institutional study we investigated the neurorestorative efficacy of a dietary approach (Fortasyn) comprising docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium as therapeutic approach to counteract neuroinflammation and impairments of cerebral (structural+functional) connectivity, cerebral blood flow (CBF), and motor function. Male adult C57BL/6j mice were subjected to right tMCAo using the intraluminal filament model. Following tMCAo, animals were either maintained on Control diet or switched to the multicomponent Fortasyn diet. At several time points after tMCAo, behavioral tests, and MRI and PET scanning were conducted to identify the impact of the multicomponent diet on the elicited neuroinflammatory response, loss of cerebral connectivity, and the resulting impairment of motor function after experimental stroke. Mice on the multicomponent diet showed decreased neuroinflammation, improved functional and structural connectivity, beneficial effect on CBF, and also improved motor function after tMCAo. Our present data show that this specific dietary intervention may have beneficial effects on structural and functional recovery and therefore therapeutic potential after ischemic stroke.

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B₀ shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations

et al. 2020

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Magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) allow the chemical analysis of physiological processes in vivo and provide powerful tools in the life sciences and for clinical diagnostics. Excellent homogeneity of the static B 0 magnetic field over the object of interest is essential for achieving high-quality spectral results and quantitative metabolic measurements. The experimental minimization of B 0 variation is performed in a process called B 0 shimming. In this article, we summarize the concepts of B 0 field shimming using spherical harmonic shimming techniques, specific strategies for B 0 homogenization and crucial factors to consider for implementation and use in both brain and body. In addition, experts' recommendations are provided for minimum requirements for B 0 shim hardware and evaluation criteria for the primary outcome of adequate B 0 shimming for MRS and MRSI, such as the water spectroscopic linewidth.

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Effect of perinatally supplemented flavonoids on brain structure, circulation, cognition, and metabolism in C57BL/6J mice

Cited by 11 publications

References 63 publications

The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)

The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)

A specific dietary intervention to restore brain structure and function after ischemic stroke

B₀ shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations

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Effect of perinatally supplemented flavonoids on brain structure, circulation, cognition, and metabolism in C57BL/6J mice

Cited by 11 publications

References 63 publications

The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)

The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)

A specific dietary intervention to restore brain structure and function after ischemic stroke

B0 shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations

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B₀ shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations