Effect of Periodontal Therapy on Serum Levels of IL-6 in Type 2 Diabetics: A Systematic Review

Lima, Rafael Paschoal Esteves; Belém, Fernanda Vieira; Abreu, Lucas Guimarães; Cunha, Fabiano Araújo; Cota, Luís Otávio Miranda; Costa, José Eustáquio da; Costa, Fernando Oliveira

doi:10.11607/prd.3866

Cited by 17 publications

(10 citation statements)

References 11 publications

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“…Non-surgical periodontal treatment (''deep cleaning") consisting of removing soft (dental plaque) and hard (calculus, ''tartar") deposits from both the surface of the teeth above (coronally to) the gum line and below (apically to) the gum line in the pockets between the teeth and the gingiva can be performed by dental care professionals in general dental offices. Such treatment reduces the level of inflammatory biomarkers in both gingivo-crevicular fluid (inflammation exudate in the periodontal pocket) [83], saliva [84,85], and serum [20,86]. A systematic review concluded that periodontal therapy in type 2 diabetes leads to significant decreases in the inflammatory markers tumor necrosis factor-alpha (TNF-a) and C-reactive protein (CRP) [87].…”

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confidence: 99%

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IDF Diabetes Atlas: Diabetes and oral health – A two-way relationship of clinical importance

Borgnakke

2019

Diabetes Research and Clinical Practice

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The current scientific evidence for the bi-directional associations between oral health and diabetes is summarized. The universal biologic mechanisms and demographic and behavioral risk drivers underlying these associations in both directions are also described. Dysglycemia, even slightly elevated blood sugar levels, adversely affects oral health, manifesting itself in several oral diseases and conditions. In the opposite direction, any oral infection with its subsequent local and systemic inflammatory responses adversely affects blood glucose levels. Moreover, painful, mobile, or missing teeth may lead to intake of soft food items representing a sub-optimal diet and hence poor nutrition, and thereby contribute to incident type 2 diabetes or to poorer glucose control in existing diabetes. Treatment of inflammation related oral conditions, such as non-surgical periodontal treatment and extraction of infected teeth, can lead to a clinically significant decrease in blood glucose levels. Attention to infectious oral diseases and referral to dental care professionals for treatment can therefore be an important novel tool for medical care professionals in preventing and managing diabetes mellitus. Dental professionals can detect unrecognized potential dysglycemia and refer for medical examination. Such interprofessional, patient centered care may contribute to improved health, wellbeing, and quality of life in people with diabetes.

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“…A systematic review concluded that periodontal therapy in type 2 diabetes leads to significant decreases in the inflammatory markers tumor necrosis factor-alpha (TNF-a) and C-reactive protein (CRP) [87]. Another systematic review found a decrease in interleukin-6 (IL-6) when controlling for obesity [86].…”

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confidence: 99%

IDF Diabetes Atlas: Diabetes and oral health – A two-way relationship of clinical importance

Borgnakke

2019

Diabetes Research and Clinical Practice

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“…IL-6 is a pro-inflammatory mediator directly related to diabetes, since it induces insulin resistance and periodontal disease in the process of bone resorption. 37 This marker is synthesized during infectious stimulation or aggression and activates the acute immune response. 37 The salivary levels of IL-6 tend to reflect blood levels.…”

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confidence: 99%

Expression of inflammatory mediators in periodontitis and T2D patients: a systematic review and meta-analysis

et al. 2022

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“…A systematic review and meta-analysis found a statistically significant mean difference in favor of patients undergoing PMPR compared with the control group for CRP (−1.28 mg/L) and TNF-a (−1.33 pg/mL) after a follow-up period of from 1–12 months [ 51 ]. Another more recent systematic review including studies with follow-ups ranging between 3–6 months reported that PMPR contributes to the reduction of IL-6 serum levels in patients with type 2 diabetes mellitus [ 52 ].…”

Section: Effects Of Periodontal Treatment On Systemic Health In Both ...mentioning

confidence: 99%

Managing the Systemic Impact of Periodontitis

et al. 2022

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Periodontitis is a microbially driven host-mediated disease that leads to loss of periodontal attachment and bone. It is associated with elevation of systemic inflammatory markers and with the presence of systemic co-morbidities. Furthermore, periodontal treatment leads to a 24–48 h-long acute local and systemic inflammatory response. This systemic response might increase the burden of patients with compromised medical history and/or uncontrolled systemic diseases. The correlation between periodontitis and systemic diseases, the impact of periodontitis on the quality of life and public health, the effects of periodontal treatment on systemic health and disease, and the available methods to manage systemic inflammation after periodontal therapy are discussed. The main focus then shifts to a description of the existing evidence regarding the impact of periodontitis and periodontal treatment on systemic health and to the identification of approaches aiming to reduce the effect of periodontitis on systemic inflammation.

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Effect of Periodontal Therapy on Serum Levels of IL-6 in Type 2 Diabetics: A Systematic Review

Cited by 17 publications

References 11 publications

IDF Diabetes Atlas: Diabetes and oral health – A two-way relationship of clinical importance

IDF Diabetes Atlas: Diabetes and oral health – A two-way relationship of clinical importance

Expression of inflammatory mediators in periodontitis and T2D patients: a systematic review and meta-analysis

Managing the Systemic Impact of Periodontitis

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