Effect of periodontal therapy on adipokine biomarkers in overweight

Matern, Johannes; Koch, Raphael; Petersmann, Astrid; Kocher, Thomas; Eickholz, Peter; Lorenz, K.; Kim, Ti‐Sun; Meyle, Joerg; Kaner, Doğan; Schlagenhauf, Ulrich; Gravemeier, Martina; Harks, Inga; Ehmke, Benjamin

doi:10.1111/jcpe.13288

Cited by 5 publications

(9 citation statements)

References 37 publications

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“…Two hundred and five studies were excluded (Appendix 3: T2 ). Twenty‐six studies (Tonetti et al, 2007 ; Higashi et al, 2009 ; Katagiri et al, 2009 ; Offenbacher et al, 2009 ; Pinho Mde et al, 2009 ; Chen et al, 2012 ; López et al, 2012 ; Caúla et al, 2014 ; Kapellas et al, 2014 ; Koromantzos et al, 2012 ; Fang et al, 2015 ; Hada et al, 2015 ; Geisinger et al, 2016 ; Deepti et al, 2017 ; Mizuno et al, 2017 ; Wang et al, 2017 , 2020 ; Zhou et al, 2017 ; D'Aiuto et al, 2018 ; Grubbs et al, 2020 ; Lobo et al, 2020 ; Matern et al, 2020 ; Montero et al, 2020 ; Nguyen et al, 2021 ; Rapone et al, 2021 ; Vachhani & Bhavsar, 2021 ) met the inclusion criteria and were included in the descriptive analysis. Evidence tables were generated according to the study design and in chronological order (Appendix 3: T3 ).…”

Section: Resultsmentioning

confidence: 99%

Treatment of periodontitis and C‐reactive protein: A systematic review and meta‐analysis of randomized clinical trials

Luthra

Orlandi

Hussain

et al. 2022

J Clinic Periodontology

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Background: Systemic inflammation is implicated in the onset and progression of several chronic diseases. Periodontitis is a potential trigger of systemic inflammation.Purpose: To comprehensively appraise all the evidence on the effects of the treatment of periodontitis on systemic inflammation assessed by serum C-reactive protein (CRP) levels.Data Sources: Six electronic databases were searched up to 10 February 2022 to identify and select articles in English language only.Study Selection: Twenty-six randomized controlled clinical trials reporting changes amongst 2579 participants about CRP levels at 6 months or more after treatment.Data Extraction: Two reviewers independently extracted data and rated the quality of studies. Meta-analyses were performed using random and fixed effect models.Risk of Bias: Risk of bias (RoB 2.0 tool) and quality of evidence (GRADEpro GDT tool) analyses were completed.Data Synthesis: Treatment of periodontitis reduced CRP levels by 0.69 mg/L (95% confidence interval: À0.97 to À0.40) after 6 months, but limited evidence was retrieved from studies with longer follow-ups. Similar findings were observed in

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Section: Resultsmentioning

confidence: 99%

Treatment of periodontitis and C‐reactive protein: A systematic review and meta‐analysis of randomized clinical trials

Luthra

Orlandi

Hussain

et al. 2022

J Clinic Periodontology

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“…The Kappa score was 0.95. The selected studies were assessed for quality using the Newcastle-Ottawa Scale for included observational studies [19,26,28,30,33] and Cochrane-advocated ROB-2 tool for evaluating the risk of bias in RCTs [35,36]. For assessing risk of bias of non-RCTs, the ROBINS-I tool was used by looking into preintervention, intervention, and postintervention domains.…”

Section: Data Extraction and Quality Assessmentmentioning

confidence: 99%

“…The sample size of these studies ranged from 50 to 231. Among the seven incorporated studies, three of them were set in Asia (China [28,30]; India [26]); meanwhile, two of them were set in Europe (Spain [23]; Germany [19]) and two of them were set in Turkey, Asia, and Europe [33,34], which reflected the relatively diverse ethnicities. Five of the included seven studies were observational studies [19,26,28,30,33].…”

Section: Characteristics and Quality Assessment Of Studymentioning

confidence: 99%

“…Among the seven incorporated studies, three of them were set in Asia (China [28,30]; India [26]); meanwhile, two of them were set in Europe (Spain [23]; Germany [19]) and two of them were set in Turkey, Asia, and Europe [33,34], which reflected the relatively diverse ethnicities. Five of the included seven studies were observational studies [19,26,28,30,33]. Most of them were designed as a typical case-control form, while one study [34] was set as an interventional study as the effect of nonsurgical periodontal treatment.…”

Section: Characteristics and Quality Assessment Of Studymentioning

confidence: 99%

“…However, the prior studies demonstrated a rather equivocal conclusion about the association between the level of RBP4/visfatin and periodontitis patients with obesity [18,19]. To further investigate the role of RBP4 and visfatin as the path mechanistic link between periodontitis and obesity, we, thereby, carried out this systematic review and meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

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Retinol-Binding Protein 4 and Visfatin Levels in Patients with Periodontitis and Obesity/Overweight: A Systematic Review and Meta-Analysis

Zhang,

Jia,

Zhang

et al. 2023

CIMB

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Prior studies demonstrated an equivocal conclusion about the association between the level of retinol-binding protein 4 (RBP4)/visfatin and periodontitis patients with obesity. The aim of our study (Prospero ID: CRD42023469058) was to systematically review the available articles linking the biofluid levels of RBP4/visfatin to the comorbidity of periodontitis and obesity. Clinical trials were screened in accordance with specific inclusion criteria from seven databases up to November 2023. A quality assessment was performed with the Newcastle–Ottawa Scale and ROBINS-I tools for observational and interventional trials, respectively. The standard mean difference (SMD) with a 95% confidence interval (CI) related to the RBP4 level was recorded; the other indicators related to the visfatin level were measured via the mean difference (MD) with the corresponding 95% CI, and Fisher’s Z transformation was measured to reveal the association using Review Manager 5.4. The current evidence was based on five observational studies and two interventional studies. All of them were included in the systematic review, and six of them were in the meta-analysis. Statistical analysis indicated that there was no significant difference in the circulating levels of RBP4 in the periodontitis patients with obesity or without, who were labeled as OP or NP, respectively (155 OP-107 NP: SMD = 1.38; 95% CI: −0.18–2.94, p = 0.08), as well as the periodontal healthy patients with a normal weight, who were labelled as NnP (116 OP-79 NnP: SMD = 6.76; 95% CI: −5.34–18.87, p = 0.27). Meanwhile, a significant higher level of serum visfatin was found in the OP patients than that of the NP (86 OP-45 NP: MD = 4.21; 95% CI: 2.65–5.77, p < 0.00001)/NnP (164 OP-88 NnP: MD = 13.02; 95% CI: 7.34–18.70, p < 0.00001) group. In addition, a positive association was observed between the serum RBP4 and body mass index/clinical attachment loss (CAL). And, then, there was a positive association between the serum visfatin and periodontal parameters, including the probing depth, CAL, and plaque index, as well as metabolic parameters, including the total cholesterol, triglycerides, fasting blood glucose, and low-density lipoprotein cholesterol. Here, the circulating RBP4 level was not independently related to the comorbidity of periodontitis and obesity, while serum visfatin was significantly associated with periodontitis and obesity. Notably, the positive association between circulating RBP4/visfatin and the periodontal parameters/metabolic parameters firmly suggested that the higher severity of the obese or periodontal status was associated with an elevated level of serum visfatin or RBP4 in the OP group. With more rigorous longitudinal research, the exact causations between RBP4/visfatin and the patients affected by obesity and periodontitis could be disentangled. RBP4 and visfatin might be novel, enlightening prospective bio-indexes for the targeted treatment of comorbidities.

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Association between clinical measures of gingival inflammation and obesity in adults: systematic review and meta-analyses

et al. 2021

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Effect of periodontal therapy on adipokine biomarkers in overweight

Cited by 5 publications

References 37 publications

Treatment of periodontitis and C‐reactive protein: A systematic review and meta‐analysis of randomized clinical trials

Treatment of periodontitis and C‐reactive protein: A systematic review and meta‐analysis of randomized clinical trials

Retinol-Binding Protein 4 and Visfatin Levels in Patients with Periodontitis and Obesity/Overweight: A Systematic Review and Meta-Analysis

Association between clinical measures of gingival inflammation and obesity in adults: systematic review and meta-analyses

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