Effect of periodontal treatment on adipokines in type 2 diabetes

Ogawa, Hiroshi; Damrongrungruang, Teerasak; Hori, Shigeru; Nouno, Kaname; Minagawa, Kimino; Sato, Misuzu; Miyazaki, Hideo

doi:10.4239/wjd.v5.i6.924

Cited by 18 publications

(21 citation statements)

References 92 publications

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“…Similarly, a limited number of studies have investigated the role of adipokines in periodontal disease and diabetes 8 . A positive activity of adipsin in improving β cell function in diabetes has been recently described; 40 however, there are no reports with regard to adipsin and periodontal health or disease 41 . In the current study, the levels of both systemic inflammatory mediators, IL‐6 and adipsin, are quantified after HFD challenge, and their levels correlated with bone loss volume, suggesting a new conclusive model for studying the immune–genetic axis in the development of t2DM and periodontitis comorbidity induced by HFD.…”

Section: Discussionmentioning

confidence: 99%

Collaborative Cross Mouse Population for Studying Alveolar Bone Changes and Impaired Glucose Tolerance Comorbidity After High‐Fat Diet Consumption

Nashef

Atamni

Buchnik

et al. 2017

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Collaborative Cross Mouse Population for Studying Alveolar Bone Changes and Impaired Glucose Tolerance Comorbidity After High‐Fat Diet Consumption

Nashef

Atamni

Buchnik

et al. 2017

Journal of Periodontology

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“…(30) reported that adipokines had an impact on the pathogenesis of T2DM and periodontitis. Some adipokines (leptin) have an anti-inflammatory influence on tissue fortification whereas others (resistin and visfatin) have a pro-inflammatory influence.…”

Section: Discussionmentioning

confidence: 99%

Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus

et al. 2016

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Abstract:The aims of the present study were to determine the levels of vaspin and omentin-1 in gingival crevicular fluid (GCF) in patients with chronic periodontitis (CP) with and without type 2 diabetes mellitus (T2DM), and to evaluate GCF vaspin and omentin-1 levels after non-surgical periodontal therapy. The study included 60 subjects: 15 systemically and periodontally healthy individuals, 15 periodontally healthy patients with T2DM, 15 systemically healthy patients with CP, and 15 patients with both CP and T2DM. GCF and clinical periodontal parameters were examined at the baseline and 6 weeks after periodontal therapy. Levels of vaspin, omentin-1 and tumor necrosis factor-alpha (TNF-α) were measured by ELISA, and their relative ratios were calculated. GCF vaspin and TNF-α levels were significantly higher in the CP groups than in the periodontally healthy groups (P < 0.008) and decreased after therapy in the former (P < 0.025). GCF omentin-1 levels were significantly lower in the CP groups than in the periodontally healthy groups (P < 0.008) and increased after therapy in the former (P < 0.05). Statistically significant positive correlations were found between the total amount of vaspin and TNF-α, glycated hemoglobin (HbA1c), clinical attachment level and gingival index, whereas the level of omentin-1 was negatively correlated with these parameters in all groups (P < 0.05). We found that non-surgical periodontal therapy influenced the GCF levels of both vaspin and omentin-1 in the CP groups. IntroductionChronic peridontitis (CP) is an infectious condition that degrades and deteriorates the vital periodontal tissues around the teeth (1). The deterioration of soft and hard tissues resulting from periodontitis is due to stimulation of the host immunoinflammatory reaction to pathogens in the mouth (2). The host response to these infectious pathogens leads to dispersal of inflammatory mediators, including the pro-inflammatory cytokines interleukin-1 (IL-1), IL-6, tumor necrosis factor alpha (TNF-α), and prostaglandins (PGE2), the latter exacerbating deterioration of the periodontium. The increased cytokine levels present in periodontitis are also likely to aggravate existing conditions, such as atherosclerosis, diabetes, and rheumatoid arthritis (3). A number of theories have been offered to explain the

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“…Traditionally, the inflammatory cytokines were thought to have been generated by macrophages. They are, therefore, used to explain the connection between inflammation and resistance to insulin 11 …”

mentioning

confidence: 99%

Chemerin as a Novel Crevicular Fluid Marker of Patients With Periodontitis and Type 2 Diabetes Mellitus

Doğan

Ballı

Dede

et al. 2016

Journal of Periodontology

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Effect of periodontal treatment on adipokines in type 2 diabetes

Cited by 18 publications

References 92 publications

Collaborative Cross Mouse Population for Studying Alveolar Bone Changes and Impaired Glucose Tolerance Comorbidity After High‐Fat Diet Consumption

Collaborative Cross Mouse Population for Studying Alveolar Bone Changes and Impaired Glucose Tolerance Comorbidity After High‐Fat Diet Consumption

Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus

Chemerin as a Novel Crevicular Fluid Marker of Patients With Periodontitis and Type 2 Diabetes Mellitus

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