Effect of Periodontal Treatment on Serum C‐Reactive Protein Levels: A Systematic Review and Meta‐Analysis

Ioannidou, Effie; Malekzadeh, Tannaz; Dongari-Bagtzoglou, Anna

doi:10.1902/jop.2006.050443

Cited by 104 publications

(99 citation statements)

References 39 publications

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“…After reviewing all clinical trials, authors agreed to perform metaanalysis only on markers where sufficient data were available (Table 1). One biomarker had been recently extensively reviewed and more than one systematic review with metaanalysis had been already published (Ioannidou et al 2006, Paraskevas et al 2008, Freitas et al 2012. We therefore did not include it in a meta-analysis.…”

Section: Methodsmentioning

confidence: 99%

Evidence that periodontal treatment improves biomarkers and CVD outcomes

D’Aiuto

Orlandi

Gunsolley

2013

Journal of Periodontology

128

137

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Evidence that periodontal treatment improves biomarkers and CVD outcomes D'Aiuto F, Orlandi M, Gunsolley JC. Evidence that periodontal treatment improves biomarkers and CVD outcomes. AbstractAim: The aim of this review was to critically appraise the evidence on the impact of periodontal treatment of cardiovascular diseases (CVDs) biomarkers and outcomes. Methods: A systematic search was performed in Cinhal, Cochrane, Embase and Medline for relevant articles up to July 2012. Duplicate screening and reference hand searching were performed. Data were then summarized and evidence graded in tables. Results: The search resulted in: (a) no evidence on the effects of periodontal therapy on subclinical atherosclerosis, serum levels of CD40 ligand, serum amyloid A and monocyte chemoattractant protein-1, (b) limited evidence on the effects of periodontal therapy on arterial blood pressure, leucocyte counts, fibrinogen, tissue necrosis factor-a, sE-selectin, von Willebrand factors, d-dimers, matrix metalloproteinases, oxidative stress and CVD events, and (c) moderate evidence suggesting a negligible effect of periodontal therapy in reducing interleukin-6 and lipids levels, whilst a positive effect in reducing serum C-reactive protein levels and improving endothelial function. Conclusions: Periodontal therapy triggers a short-term inflammatory response followed by (a) a progressive and consistent reduction of systemic inflammation and (b) an improvement in endothelial function. There is however limited evidence that these acute and chronic changes will either increase or reduce CVD burden of individuals suffering from periodontitis in the long term.

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Section: Methodsmentioning

confidence: 99%

Evidence that periodontal treatment improves biomarkers and CVD outcomes

D’Aiuto

Orlandi

Gunsolley

2013

Journal of Periodontology

128

137

View full text Add to dashboard Cite

show abstract

“…Secondly, although very short-term effect was evaluated, the mean CRP levels at the end of evaluation period were almost similar to baseline values in both groups. Effect of periodontal treatment on CRP levels in longer periods, as mentioned elsewhere [1] was not evaluated. A third limitation of this study is the number of individuals included in this analysis is relatively small…”

Section: Discussionmentioning

confidence: 99%

“…ic periodontitis and elevated serum C-reactive Protein (CRP) levels [1]. However, in order to determine whether this increase was due to periodontal infections or not, the possible effects of periodontal therapy on CRP levels were also investigated in numerous studies [2,[3][4][5][6][7].…”

mentioning

confidence: 99%

Effect of Antibiotic Prophylaxis on Serum CRP Level Immediately Following Periodontal Treatment: An Experimental Clinical Study

Boduroglu¹

2014

Int J Oral Dent Health

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“…It has been suggested that oral hygiene practices are responsible for spontaneous cases of bacteraemia. Such bacteraemias either from periodontal procedures or oral hygiene practices are of low-grade intensity (10 -200 CFU/ml of blood) and of short duration [15]. Bacteremia induced by Porphyromonas gingivalis (Pg) leads to intimal hyperplasia associated with overexpressions of embryonic isoform of myosin heavy chain and oral hematogenous spreading of Pg is a causative event in the development of aortic hyperplasia in periodontitis patients [56].…”

Section: Maharajmentioning

confidence: 99%

“…Periodontal therapy has had some success in the modification of many of inflammatory indicators in systemically healthy adults [15]. Thus we must make sure if periodontal intervention could lower the risk of cardiovascular events or even prevent onset and progression of the disease.…”

Section: Introductionmentioning

confidence: 99%

Is a Potential Therapeutic Strategy of Periodontal Intervention on Cardiovascular Disease, Yes or No?

Chen¹,

Zhang²,

Xu³

et al. 2017

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Aims: Cardiovascular disease (CVD) and periodontitis are both chronic inflammatory disorders which are highly prevalent in populations. Bacteria involved in the periodontal disease have been found to be cardiovascular risk markers. Periodontal pathogens may contribute to the atheroma pathogenesis. Severe periodontitis is correlated with the prevalence of bacteraemia, and poor periodontal status is an important risk factor for CVD. However, the association is unclear. If the association is causal, the periodontal therapy will lead to an attenuation of the effects on CVD. The study aimed to study if the periodontal intervention therapy presented therapeutic effects on CVD. Methods: English language literature on periodontal intervention therapy on CVD is causal or not. The literature revealed 62 papers associated with this study to investigate the relationship between periodontitis and CVD. Results: The literature supported the idea that periodontal infections had been associated with CVD. Certain periodontal therapy is associated with bacteraemia, and the prevalence of bacteraemia may arise from periodontal therapy and poor oral hygiene practices. Periodontal therapy not only presented therapeutic effects by reducing cytokine activity and C-response protein (CRP), but also caused bacteraemia transitorily. Effective antibiotic prophylaxis pre-or post-periodontal therapy presented some beneficial effects on bacteraemia or CVD. Conclusion: Severe periodontitis causes systemic inflammation and endothelial dysfunction, and goes beyond the oral cavity. Periodontal intervention would contribute to the prevention of atherosclerosis, and antibiotic prophylaxis would be helpful to decrease bacteraemia and reduce the onset of CVD.

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Effect of Periodontal Treatment on Serum C‐Reactive Protein Levels: A Systematic Review and Meta‐Analysis

Abstract: There is now a large body of evidence to indicate that systemic inflammation is present in patients with periodontal disease. Thus, information from RCTs and single-cohort studies does not support the hypothesis that periodontal treatment can reduce systemic CRP levels.

Cited by 104 publications

References 39 publications

Evidence that periodontal treatment improves biomarkers and CVD outcomes

Evidence that periodontal treatment improves biomarkers and CVD outcomes

Effect of Antibiotic Prophylaxis on Serum CRP Level Immediately Following Periodontal Treatment: An Experimental Clinical Study

Is a Potential Therapeutic Strategy of Periodontal Intervention on Cardiovascular Disease, Yes or No?

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