Effect of periodontal treatments on blood pressure

Luo, Yiliao; Ye, Huilin; Liu, Wei; Lv, Zongkai; Jia, Yuanyuan; Li, Chunjie; Zhang, Yifan

doi:10.1002/14651858.cd009409.pub2

Cited by 12 publications

(11 citation statements)

References 73 publications

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“…Besides, periodontitis seems to be independently associated with hypertension, as shown by two recent systematic reviews [ 51 , 52 ]. However, high heterogeneity among the included studies may be attributed to different study designs [ 53 , 54 ], case definition [ 53 ] and inability to detect periodontitis-hypertension association [ 54 – 56 ]. Furthermore, the systematic review by Martin-Cabezas et al [ 51 ] indicates that common risk factors hamper assessing the actual nature of the periodontitis-hypertension association.…”

Section: Introductionmentioning

confidence: 99%

Periodontal and systemic health of morbidly obese patients eligible for bariatric surgery: a cross-sectional study

et al. 2022

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Background In obese patients, periodontitis might be associated with deprived systemic health. Edmonton obesity staging system (EOSS) is a new tool for classification of obesity that considers the metabolic, physical, and psychological health. The cross-sectional study aimed to evaluate the periodontal status of morbidly obese patients eligible for bariatric surgery and the association between periodontitis, obesity-related comorbidities, and EOSS. Methods Morbidly obese patients eligible for bariatric surgery underwent detailed periodontal examination and were divided into the periodontitis group (PG) and the non-periodontitis group (NPG). The medical and demographic data were obtained from medical files, while behavioural data were obtained by the interview. Descriptive statistics and simple statistical tests were used to summarise the characteristics of the sample and the differences between PG and NPG. The logistic regression models were used to calculate the association (odds ratio (OR)) between periodontitis and obesity-related diseases and EOSS. Results The study included 79 patients, with an average BMI of 44.6 kg/m2 (SD = 7.2). The prevalence of periodontitis was 65% (CI 95% 53%-75%). PG patients (n = 51) were older, more often smokers and were more often hypertensive than NPG patients (n = 28) (p < 0.05). Hypertension was positively associated with periodontitis with adjusted OR 3.98 (95% CI 1.23–12.8; p = 0.021)) and age with adjusted OR 1.06, (95% CI 1.01–1.13; p = 0.038)), while other tested conditions (diabetes, dyslipidaemia, and smoking habits) did not show significant association with periodontitis. Periodontitis did not correlate with EOSS or other obesity-related comorbidities (p > 0.05). Conclusion The morbidly obese patients eligible for bariatric surgery show a high prevalence of periodontitis and, therefore, are advised to be examined by a dentist before undergoing surgery. They have higher odds of hypertension but not of other obesity-related diseases or higher stages of EOSS. The medical personnel should raise awareness among obese patients on the potential association of poor periodontal health with hypertension. Trial registration NCT04653714.

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Section: Introductionmentioning

confidence: 99%

Periodontal and systemic health of morbidly obese patients eligible for bariatric surgery: a cross-sectional study

et al. 2022

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“…If periodontal inflammation is present, although not of sufficient intensity and duration to cause tooth loss, periodontitis of the present teeth may represent the limited inflammatory effect of actual atherosclerotic changes. In contrast, in participants with 4 -28 missing teeth, AL was not to hypertension and atherosclerosis 37,38,40) . In the multivariate analysis in the present study, although there was a close correlation between BP and maximum IMT, the association between periodontitis and maximum IMT was independent of BP (Supplementary Table 3).…”

Section: Discussionmentioning

confidence: 70%

“…Many studies have suggested that periodontitis is associated with hypertension 29,32,[36][37][38] . Proinflammatory cytokines may lead to endothelial dysfunction by influencing endothelial cells, decreasing local availability of endothelium-derived relaxing factor (i.e., nitric oxide [NO]), which relaxes vascular vessels 37,39) .…”

Section: Discussionmentioning

confidence: 99%

Associations Among Tooth Loss, Periodontitis, and Carotid Intima-Media Thickness: the Nagahama Study

Fukuhara

Watanabe

Yamazaki

et al. 2023

JAT

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Aims: This study aimed to clarify the relationships among tooth loss, periodontal condition, and subclinical atherosclerosis from the aspect of intensity, extent, and duration of inflammation. Methods:This cross-sectional study included 9,778 people from the Nagahama Study, a large-scale, general population-based study conducted in Japan. The number of teeth and periodontal status, including the attachment level (AL) and pocket depth (PD) of representative teeth from six regions, were evaluated by dentists. The maximum intima-media thickness (IMT) of the common carotid artery was used as an index of atherosclerosis. Results:In the multivariate analysis adjusted for conventional risk factors, a large number of missing teeth (＜9 remaining teeth), which related to long-lasting inflammation indicative of the highest stage of periodontitis, was identified as an independent determinant of IMT in a general population (coefficient: 0.042; 95% confidence interval [CI]: 0.016 to 0.068). The presence of two or more regions with an AL ≥ 4 mm, which is indicative of the progressing, long-lasting stages of periodontal inflammation, was also independently associated with IMT (coefficient: 0.016; 95% CI: 0.004 to 0.028). On the contrary, PD, a measure of the early and reversible phases of periodontal inflammation, and loss of AL in the group without tooth loss were not significantly associated with IMT, because of the limited degree of accumulated periodontitis. Conclusion:The present results suggest that the association between periodontitis and atherosclerosis depends on the inflammation intensity, extent, and duration.

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“…Periodontitis is a chronic inflammatory disease of the periodontal tissue caused by plaque biofilm, which acts as a potential risk factor for a variety of systemic diseases, including cardiovascular disease, diabetes, hypertension, various cancers, COPD, etc. ( 5 , 42 , 43 ). As is commonly known, globally, chronic respiratory diseases act as the leading cause of death and morbidity, among which COPD causes the most deaths, and is considered the third leading cause of death worldwide ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

Periodontitis aggravates COPD through the activation of γδ T cell and M2 macrophage

Xiong,

Ao,

Wei

et al. 2024

mSystems

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Chronic obstructive pulmonary disease (COPD) is a chronic systemic inflammatory disease with high morbidity and mortality. Periodontitis exacerbates COPD progression; however, the immune mechanisms by which periodontitis affects COPD remain unclear. Here, by constructing periodontitis and COPD mouse models, we demonstrated that periodontitis and COPD could mutually aggravate disease progression. For the first time, we found that the progression was associated with the activation of γδ T cells and M2 macrophages, and M2 polarization of macrophages was affected by γδ T cells activation. In the lung tissues of COPD with periodontitis, the activation of γδ T cells finally led to the increase of IL 17 and IFN γ expression and M2 macrophage polarization. Furthermore, we found that the periodontitis-associated bacteria Porphyromonas gingivalis ( P. gingivalis ) promoted the activation of γδ T cells and M2 macrophages ex vivo . The data from clinical bronchoalveolar lavage fluid (BALF) samples were consistent with the in vivo and ex vivo experiments. For the first time, our results identified the crucial role of γδ T-M2 immune mechanism in mediating periodontitis-promoted COPD progression. Therefore, targeting at periodontitis treatment and the γδ T-M2 immune mechanism might provide a new practical strategy for COPD prevention or control. IMPORTANCE Periodontitis exacerbates chronic obstructive pulmonary disease (COPD) progression. For the first time, the current study identified that the impact of periodontitis on COPD progression was associated with the activation of γδ T cells and M2 macrophages and that M2 polarization of macrophages was affected by γδ T cells activation. The results indicated that targeting at periodontitis treatment and the γδ T-M2 immune mechanism might provide a new practical strategy for COPD prevention or control.

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Effect of periodontal treatments on blood pressure

Cited by 12 publications

References 73 publications

Periodontal and systemic health of morbidly obese patients eligible for bariatric surgery: a cross-sectional study

Periodontal and systemic health of morbidly obese patients eligible for bariatric surgery: a cross-sectional study

Associations Among Tooth Loss, Periodontitis, and Carotid Intima-Media Thickness: the Nagahama Study

Periodontitis aggravates COPD through the activation of γδ T cell and M2 macrophage

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