Effect of Periodontitis on Cardiovascular Manifestations in Marfan Syndrome

Suzuki, Jun–ichi; Aoyama, Norio; Izumi, Yuichi; Isobe, Mitsuaki; Komuro, Issei; Hirata, Yasunobu

doi:10.1536/ihj.14-247

Cited by 12 publications

(10 citation statements)

References 41 publications

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“…[17][18][19] We previously showed that periodontopathic pathogens deteriorated ventricular remodeling after MI 20,21) and other cardiovascular diseases. [22][23][24][25][26] However, a detailed mechanism is still to be elucidated. We hypothesized that infection with a periodontal pathogen, P.g., could cause an adverse outcome after MI via HMGB1.…”

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confidence: 99%

<i>Porphyromonas Gingivalis</i> Elevated High-Mobility Group Box 1 Levels After Myocardial Infarction in Mice

et al. 2017

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SummaryHigh mobility group box 1 (HMGB1) is a nuclear protein released from necrotic cells, inducing inflammatory responses. Epidemiological studies suggested a possible association between periodontitis and cardiovascular diseases (CVDs). Due to tissue damage and necrosis of cardiac cells following myocardial infarction (MI), HMGB1 is released, activating an inflammatory reaction. However, it remains unclear whether periodontitis is also involved in myocardial damage. The purpose of this study was to determine the effect of the periodontal pathogen Porphyromonas gingivalis (P.g.) after MI in mice.C57BL/6J wild type mice in post-MI were inoculated with P.g. in the infected group (P.g.-inoculated MI group) and with phosphate buffer saline (PBS) in the control group (PBS-injected MI group). Plasma samples and twelve tissue samples from mice hearts after MI were obtained. We determined the expression of HMGB1 by ELISA and immunohistochemistry.The level of HMGB1 protein in the P.g.-inoculated MI group was significantly higher than in the PBSinjected MI group on day 5, but not on day 14. Immunohistochemistry analysis revealed that HMGB1 was mainly expressed in cardiomyocytes, immune cells, and vascular endothelial cells in the PBS-injected MI group, while HMGB1 was seen broadly in degenerated cardiomyocytes, extracellular fields, immune cells, and vascular endothelial cells in the P.g.-inoculated MI group. A significant increase in the number of HMGB1 positive cells was observed in the P.g.-inoculated MI group compared to the PBS-injected MI group.Infection with P.g. after MI enhanced myocardial HMGB1 expression. There is a possible relationship between periodontitis and post-infarction myocardial inflammation through HMGB-1.(Int Heart J 2017; 58: 762-768)

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confidence: 99%

<i>Porphyromonas Gingivalis</i> Elevated High-Mobility Group Box 1 Levels After Myocardial Infarction in Mice

et al. 2017

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“…The other cardiovascular problems include thoracic aortic dilatation/rupture, aortic regurgitation, mitral regurgitation, and abdominal aortic aneurysm. Furthermore, dentists has an important role in terms of the risk of infective endocarditis that may occur during invasive dental treatments, which should not be overlooked ( 20 ). The 90% of individuals with Marfan syndrome has cardiac disorders.…”

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confidence: 99%

Dental Findings in Marfan Syndrome: A Case Report

Bostancı¹,

Korkut²,

Ünlü³

2017

J Istanbul Univ Fac Dent

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Marfan syndrome is an autosomal dominant disorder of connective tissue primarily characterized with anomalies affecting the musculoskeletal system, the cardiovascular system and the eyes. It has been suggested that early diagnosis of the syndrome is important, because of the risk of infective endocarditis. A 7-year-old female was referred to our clinic, with a chief complaint of dental crowding in the anterior region of mandible. It was observed that the patient needed multiple treatments based on detailed clinical and radiographic examinations. The treatment was carried out with antibiotic prophylaxis an hour prior to her appointment considering her profound caries. The patient was advised to visit regularly for follow up and she was referred for orthodontic evaluation.

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“…21,22) Lastly, we reviewed the influence of periodontitis in MFS patients with cardiovascular complications to assess the critical therapeutic target of TGF-β. 23) Thus, TGF-β may be a common critical factor involved in the development of SoV dilatation, periodontitis, and MFS.…”

Section: Discussionmentioning

confidence: 99%

Periodontitis May Deteriorate Sinus of Valsalva Dilatation in Marfan Syndrome Patients

et al. 2016

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Marfan syndrome (MFS) is a systemic connective tissue disorder that is caused by mutations of fibrillin-1. While MFS patients are at a high risk of periodontitis and aortic diseases, little causal information has been provided to date. To clarify the relationship, their oral condition and sinus of Valsalva (SoV) were evaluated.The subjects were patients with MFS (n = 33) who attended the University of Tokyo Hospital. We divided them into two groups; MFS patients with highly dilated (the diameters were equal to or more than 39 mm) SoV (high group, n = 18) and MFS patients with mildly dilated (less than 39 mm) SoV (mild group, n = 15). Blood examinations, echocardiograms, and full-mouth clinical measurements, including number of teeth, probing pocket depth (PPD), bleeding on probing (BOP), and community periodontal index (CPI) were performed.We found that the high group patients had greater rates of BOP compared to that of the mild group. Furthermore, the high group tended to have higher serum levels of C-reactive protein, matrix metalloproteinase-9, and transforming growth factor-β compared to the mild group.Periodontitis may deteriorate SoV dilatation in MFS patients.

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Effect of Periodontitis on Cardiovascular Manifestations in Marfan Syndrome

Cited by 12 publications

References 41 publications

<i>Porphyromonas Gingivalis</i> Elevated High-Mobility Group Box 1 Levels After Myocardial Infarction in Mice

<i>Porphyromonas Gingivalis</i> Elevated High-Mobility Group Box 1 Levels After Myocardial Infarction in Mice

Dental Findings in Marfan Syndrome: A Case Report

Periodontitis May Deteriorate Sinus of Valsalva Dilatation in Marfan Syndrome Patients

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