Effect of Perioperative Dexmedetomidine Anesthesia on Prognosis of Elderly Patients with Gastrointestinal Tumor Surgery

Abstract

It was to investigate the influence of perioperative dexmedetomidine (DEX) anesthesia on the prognosis of elderly patients with gastrointestinal tumor (GIT) surgery. 90 patients who underwent laparoscopic radical gastrectomy for GIT were included. They were randomly divided into the experimental group (45 cases) with DEX+general anesthesia, and the control group (45 cases) with epidural anesthesia+general anesthesia. The indicators after surgery were compared between the two groups. The mean arterial pressure (MAP) was 74.8 ± 3.5 mmHg and the heart rate (HR) was 52.7 ± 8.2 beats/min-1 in the experimental group, significantly lower than those of the control group ( P < 0.05 ). The Visual Analog Scale (VAS) scores of both groups decreased greatly associated to those before surgery ( P < 0.05 ). The levels of cortisol (COR) and immune adhesion inhibitor (FEIR) in the experimental group were significantly dissimilar from those in the control group ( P < 0.05 ). The tumor necrosis factor-alpha (TNF-α) was 96.4 ± 21.8 ng/L in the experimental group, observably lower than that in the control group ( P < 0.05 ). The postoperative diamine oxidase (DAO) and D-lactate (D-lac) were 62.4 ± 9.3 μmol/mL and 33.8 ± 7.2 ng/L, respectively, in the experimental group, much lower than those in the control group ( P < 0.05 ). There were also significant differences in the initial recovery of bowel sounds, defecation, and total length of hospital stay (LOHS) between the groups ( P < 0.05 ). DEX anesthesia had ideal sedative and analgesic effects, improving the prognosis of patients during surgery, and shortening the LOHS. Thus, it deserved a clinical application value.

INTRANASAL DEXMEDETOMIDINE 2μG/Kg VERSUS 3μG/Kg ON PARENT SEPARATION IN DENTAL SURGERY: A RANDOMIZED CLINICAL TRIAL

“…Olutoye et al (2007), on healthy volunteers showed that DEX has a strong analgesic effect, making it particularly appropriate for intraoperative use. However, clinical evidence confirming the analgesic benefit of the DEX in children was lacking (Guo et al, 2022) In the same context, Bonagua et al (2020) demonstrated that nebulized DEX (2 scored higher on IV cannulation acceptance and parental separation than those who were not premedicated. Gyanesh et al (2014) obtained similar results in a randomized study for magnetic resonance imaging.…”

“…Children may become excessively uncooperative during venipuncture, mask installation, or parental separation (Liu et al, 2022). Harder induction, higher postoperative pain, emerging agitation, and possibly postoperative behavioral and psychological problems can result from untreated anxiety (Reddy and Deutsch, 2020).…”

Influences of dexmedetomidine on stress responses and postoperative cognitive and coagulation functions in patients undergoing radical gastrectomy under general anesthesia

“…Several studies have investigated the application value of DEX in RG for GC. In the study by Guo et al [ 15 ], DEX outperformed epidural anesthesia in terms of sedative and analgesic effects in elderly adults undergoing RG for GC and accelerated their recovery. Liu et al [ 16 ] focused on the influence of DEX combined with propofol on postoperative analgesia and cellular immune function during RG.…”