Effect of Perioperative Intravenous Lidocaine on Postoperative Recovery in Patients Undergoing Ileostomy Closure: Study Protocol for a Randomized Controlled Trial

Liu, Jia; Liu, Kun; Wang, Huixian; Hu, Hongli; Ye, Xiaofei; Zheng, Lihua; Bian, Jinjun; Liu, Bo

doi:10.2147/jpr.s362911

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…This dual action on both sensory and autonomic pathways makes lidocaine a promising therapeutic option for managing POI. [ 45 ]…”

Section: Resultsmentioning

confidence: 99%

“…This dual action on both sensory and autonomic pathways makes lidocaine a promising therapeutic option for managing POI. [45] This approach has shown benefits within the Enhanced Recovery After Surgery procedure by mitigating the activity of the sympathetic nervous system. In addition, perioperative intravenous lidocaine infusions indicated a marked decrease in various parameters, including the return of flatus, bowel movement, hospitalization days, and associated expenses in the lidocaine-receiving patients in contrast to the control group (P < .05).…”

Section: Lidocainementioning

confidence: 99%

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An outline of the management and prevention of postoperative ileus: A review

Iskander

2024

Medicine

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Postoperative ileus (POI) is a prevalent surgical complication, which results in prolonged hospitalization, patient distress, and substantial economic burden. The literature aims to present a brief outline of interventions for preventing and treating POI post-surgery. Data from 2014 to 2023 were gathered from reputable sources like PubMed, PubMed Central, Google Scholar, Research Gate, and Science Direct. Inclusion criteria focused on studies exploring innovative treatments and prevention strategies for POI, using keywords such as novel POI treatments, non-pharmacological prevention, POI incidence rates, POI management, and risk factors. The findings revealed that integration of preventive measures such as coffee consumption, chewing gum, probiotics, and use of dikenchuto within enhanced recovery programs has significantly reduced both the frequency and duration of POI, without any adverse effects, with minimally invasive surgical approaches showing promise as an additional preventive strategy. While treatment options such as alvimopan, NSAIDs, and acupuncture have demonstrated efficacy, the use of lidocaine has raised concerns due to associated adverse effects. The ongoing exploration of novel therapeutic strategies such as targeting the mast cells, vagal nerve stimulation and tight junction protein, and prokinetic-mediated instigation of the cholinergic anti-inflammatory trail not only holds promise for enhanced treatment but also deepens the understanding of intricate cellular and molecular pathways underlying POI. POI presents a complex challenge in various surgical specialties, necessitating a multifaceted management approach. The integration of preventive and treatment measures within enhanced recovery programs has significantly reduced POI frequency and duration.

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“…This dual action on both sensory and autonomic pathways makes lidocaine a promising therapeutic option for managing POI. [ 45 ]…”

Section: Resultsmentioning

confidence: 99%

Section: Lidocainementioning

confidence: 99%

An outline of the management and prevention of postoperative ileus: A review

Iskander

2024

Medicine

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ILEOSTIM trial: a study protocol to evaluate the effectiveness of efferent loop stimulation before ileostomy reversal

et al. 2023

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Purpose A protective loop ileostomy is the most useful method to reduce sequelae in the event of an anastomotic leakage (AL) after rectal cancer surgery. However, it requires an additional stoma reversal surgery with its own potential complications. Postoperative ileus (POI) remains the most common complication after ileostomy reversal, which leads to an increase in morbidity, length of hospital stay (LOS) and overall healthcare costs. Several retrospective studies carried out in this field have concluded that there are insufficient evidence-based recommendations about the routine application of preoperative bowel stimulation in clinical practice. Here we discuss whether stimulation of the efferent limb before ileostomy reversal might reduce POI and improve postoperative outcomes. Methods This is a multicentre randomised controlled trial to determine whether mechanical stimulation of the efferent limb during the 2 weeks before the ileostomy reversal would help to reduce the development of POI after surgery. This study was registered on Clinicaltrials.gov (NCT05302557). Stimulation will consist of infusing a solution of 500 ml of saline chloride solution mixed with a thickening agent (Resource©, Nestlé Health Science; 6.4 g sachet) into the distal limb of the ileostomy loop. This will be performed within the 2 weeks before ileostomy reversal, in an outpatient clinic under the supervision of a trained stoma nurse. Conclusion The results of this study could provide some insights into the preoperative management of these patients.

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Effect of Perioperative Intravenous Lidocaine on Postoperative Recovery in Patients Undergoing Ileostomy Closure: Study Protocol for a Randomized Controlled Trial

Cited by 2 publications

References 32 publications

An outline of the management and prevention of postoperative ileus: A review

An outline of the management and prevention of postoperative ileus: A review

ILEOSTIM trial: a study protocol to evaluate the effectiveness of efferent loop stimulation before ileostomy reversal

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