Effect of Perioperative Ketamine on Postoperative Mood and Depression: A Review of the Literature

Reinert, Justin P.; Parmentier, Brittany L.

doi:10.1080/17512433.2021.1855142

Cited by 10 publications

(7 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have demonstrated that a low dose of ketamine can reduce the incidence of anesthetic side reactions [14]. A review recently advised that parturients outside the perioperative setting could use ketamine as an analgesic or sedative to mitigate mood and depression [7], which was corresponded to our results. In our study, the VAS score was signi cantly lower in S-group during they used PCIA.…”

Section: Discussionsupporting

confidence: 81%

See 1 more Smart Citation

S-Ketamine As An Adjuvant in Patient-controlled Intravenous Analgesia for Prevention of Postpartum Depression: A Randomized Controlled Trial

Han

Miao

et al. 2021

Preprint

View full text Add to dashboard Cite

(1) Background: Postpartum depression (PPD) is a common complication after cesarean section. Recent studies have shown that intravenous S-ketamine during surgery could be effective in preventing PPD. However, no evidence shows S-ketamine used in patient-controlled intravenous analgesia (PCIA) could reduce the incidence of PPD. Our aim was to explore the effect of S-ketamine as an adjuvant in patient-controlled intravenous analgesia (PCIA) for prevention of postpartum depression. (2) Methods: In a single center, 375 parturients scheduled to undergo cesarean section were recruited and randomly assigned to two groups: Control group (C group) or S-ketamine group (S group). Parturients in both groups received PCIA, the formula of Group C: sufentanil 2 μg/kg + tropisetron 10 mg, S group was the same as C group except 0.5mg/kg S-ketamine. The primary outcome was the incidence of PPD measured by the Edinburgh Postnatal Depression Scale (EPDS) after surgery. The secondary outcomes were EPDS scores, Visual analogue scale (VAS) scores, and Ramsay Sedation Scale (RSS) scores, and incidence of related adverse events. (3) Results: A total of 275 puerpera were finally included and randomly assigned to two groups. The incidence of depression at postoperative 3, 14, 28days in C group and S group were 17.6%vs8.2%, P<0.05;24.2%vs9.8%, P<0.05, and 19.0%vs 17.2%, P=0.76, respectively). As for EPDS scores, C group and S group at 3,14, and 28 days after cesarean were 7.65±3.14vs6.00±2.47, p<0.05,7.62±3.14vs6.38±2.67, p<0.05, and 7.35±3.17vs6.90±2.78, p=0.15, respectively. Adverse events such as headache and nausea were 3.3% vs 4.1%, p=0.755; 5.9%vs8.2%, p=0.481. (4) Conclusions: 0.01mg/kg/h S-ketamine as an adjuvant in patient-controlled intravenous analgesia can significantly reduce the incidence of postpartum depression within 14 days and relieve postoperative pain within 48h after cesarean section, without increasing the incidence of adverse reactions.Trial registration: ChiCTR, ChiCTR2100050263，retrospectively registered. Registered 24/08/2021.

show abstract

Section: Discussionsupporting

confidence: 81%

“…In obvious studies, ketamine has been proved to be a powerful drug to release depression and reduce suicidal tendency in depressed patients [1,6,7]. Some reports have proved that the intravenous injection of ketamine during cesarean section could be effective in preventing postpartum depression until 3 days to 6 weeks [1,3,8].…”

Section: Introductionmentioning

confidence: 99%

S-Ketamine As An Adjuvant in Patient-controlled Intravenous Analgesia for Prevention of Postpartum Depression: A Randomized Controlled Trial

Han

Miao

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Ketamine has become of intense interest in psychiatry for use in treatment-resistant depression [62], though there is less evidence that perioperative use improves mood [63 ▪ ]. Ketamine use in treating PTSD is controversial [64], and may work better in combination with other nonpharmacologic therapies [65].…”

Section: Anesthetic Modulation Of Fear-based Pathologiesmentioning

confidence: 99%

Anesthesia and the neurobiology of fear and posttraumatic stress disorder

Vogt

Pryor

2022

Current Opinion in Anaesthesiology

View full text Add to dashboard Cite

Purpose of reviewDysfunction of fear memory systems underlie a cluster of clinically important and highly prevalent psychological morbidities seen in perioperative and critical care patients, most archetypally posttraumatic stress disorder (PTSD). Several sedative-hypnotics and analgesics are known to modulate fear systems, and it is theoretically plausible that clinical decisions of the anesthesiologist could impact psychological outcomes. This review aims to provide a focused synthesis of relevant literature from multiple fields of research.Recent findingsThere is evidence in some contexts that unconscious fear memory systems are less sensitive to anesthetics than are conscious memory systems. Opiates may suppress the activation of fear systems and have benefit in the prevention of PTSD following trauma. There is inconsistent evidence that the use of propofol and benzodiazepines for sedation following trauma may potentiate the development of PTSD relative to other drugs. The benefits of ketamine seen in the treatment of major depression are not clearly replicated in PTSD-cluster psychopathologies, and its effects on fear processes are complex.SummaryThere are multiple theoretical mechanisms by which anesthetic drugs can modulate fear systems and clinically important fear-based psychopathologies. The current state of research provides some evidence to support further hypothesis investigation. However, the absence of effectiveness studies and the inconsistent signals from smaller studies provide insufficient evidence to currently offer firm clinical guidance.

show abstract

“…Based on the diathesis-stress theory and previous literature, several potential factors related to psychological stress include education level, employment status, stoma, smoking, insomnia, cognitive reappraisal, and coping styles. 8 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 Although the above studies examined the relationship between perioperative psychological stress and some factors, their relationship with different trajectories has not been verified.…”

Section: Introductionmentioning

confidence: 99%

When experiencing a surgery: Gastrointestinal cancer patients’ longitudinal trajectories in psychological stress and their association with quality of recovery

Zhao

et al. 2022

Asia-Pacific Journal of Oncology Nursing

View full text Add to dashboard Cite

Effect of Perioperative Ketamine on Postoperative Mood and Depression: A Review of the Literature

Cited by 10 publications

References 38 publications

S-Ketamine As An Adjuvant in Patient-controlled Intravenous Analgesia for Prevention of Postpartum Depression: A Randomized Controlled Trial

S-Ketamine As An Adjuvant in Patient-controlled Intravenous Analgesia for Prevention of Postpartum Depression: A Randomized Controlled Trial

Anesthesia and the neurobiology of fear and posttraumatic stress disorder

When experiencing a surgery: Gastrointestinal cancer patients’ longitudinal trajectories in psychological stress and their association with quality of recovery

Contact Info

Product

Resources

About