Effect of peripapillary retinoschisis on retinal nerve fibre layer thickness measurement in glaucomatous eyes

Hwang, Young Hoon; Kim, Yong Yeon; Kim, Hwang Ki; Sohn, Yong Ho

doi:10.1136/bjophthalmol-2013-303931

Cited by 31 publications

(39 citation statements)

References 20 publications

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“…It showed subtle dehiscence at the nerve fiber layer in sectional OCT scans, but the affected area was dramatically larger than expected from an en face view. Recent studies showed that peripapillary retinoschisis was occasionally detected in glaucomatous eyes, [21][22][23] but all our subjects denied history of glaucoma. Intraocular pressure and perimetry test were within normal range.…”

Section: Discussionmentioning

confidence: 57%

Wide-Field En Face Swept-Source Optical Coherence Tomography Features of Extrafoveal Retinoschisis in Highly Myopic Eyes

Xiao

Zhu

Odouard

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 57%

Wide-Field En Face Swept-Source Optical Coherence Tomography Features of Extrafoveal Retinoschisis in Highly Myopic Eyes

Xiao

Zhu

Odouard

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“…[ 5 – 8 ] There has also been increased interest in peripapillary and macular retinoschisis in glaucomatous eyes recently. [ 9 – 11 ] The impact of retinoschisis on RNFL thickness measurements has been noted illustrating its effect as a confounding factor in detecting structural progression in glacuoma. [ 11 ]…”

Section: Introductionmentioning

confidence: 99%

Peripapillary retinal splitting visualized on OCT in glaucoma and glaucoma suspect patients

et al. 2017

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PurposeTo identify the risk factors for development of peripapillary retinal splitting (schisis) in patients with glaucoma or suspicion of glaucomaSettingGlaucoma Clinic, Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, ILMethodsIn this institutional cross-sectional study, 495 patients (990 eyes) who had undergone spectral-domain optical coherence tomography (OCT Spectralis HRA-OCT, Heidelberg Engineering) optic nerve head (ONH) imaging and did not have identifiable optic nerve pits, pseudopits or coloboma were included. OCT scans were reviewed by two observers.Main outcome measuresPresence of peripapillary retinal splitting identified on OCT raster scans.ResultsEleven of 990 glaucoma and glaucoma suspect eyes (1.1%) of 7 patients (2 females, 5 males, mean age 64.5 ± 9.2 years) had peripapillary retinal splitting. Two of these 11 eyes had extension of the splitting into the macula but none to the fovea. Of these 11 patients, 2 (28.6%) were glaucoma suspects, 3 (42.9%) had primary open-angle glaucoma, 1 (14.3%) had chronic angle-closure glaucoma and 1 (14.3%) had pigmentary glaucoma. 7/11 (63.6%) eyes had vitreous traction to the disc visualized on OCT and 6/11 eyes (54.5%) had beta-zone peripapillary atrophy.ConclusionsWe observed peripapillary retinal splitting in 1.1% of a series of 990 glaucoma and glaucoma-suspect eyes. Evidence of adherent vitreous with traction and peripapillary atrophy was found in a majority of the involved eyes. A comparison to an age and axial length matched cohort is required to determine if this is a condition that is associated with glaucoma.

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“…Recently, structural changes in the optical coherence tomography (OCT) findings on the inner retina of eyes with glaucoma have been reported. Multiple groups have reported peripapillary retinoschisis associated with transient increases in retinal nerve fiber layer (RNFL) thickness in glaucomatous eyes as determined by OCT. 7,8 However, glaucoma or nonglaucomaassociated optic neuropathies can lead to thickening and edema in the inner nuclear layer, termed microcystic macular edema (MME). 9,10 Nerve fiber damage and the subsequent retrograde loss of ganglion cells are thought to cause dysfunction of the Müller cells in both peripapillary retinoschisis and MME.…”

mentioning

confidence: 99%

“…9,10 Nerve fiber damage and the subsequent retrograde loss of ganglion cells are thought to cause dysfunction of the Müller cells in both peripapillary retinoschisis and MME. 7,10 In addition, retinal traction might be sufficient to cause inner nuclear layer (INL) spaces in both disease processes. 8,11 Some investigators have reported that ERMs are associated with glaucoma in some cases.…”

mentioning

confidence: 99%

Cross-Sectional Imaging Analysis of Epiretinal Membrane Involvement in Unilateral Open-Angle Glaucoma Severity

Sakimoto

Okazaki

Usui

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To determine the relevance of epiretinal membranes (ERMs) in primary open-angle glaucoma (POAG) and potential risk for glaucoma severity. METHODS. Sixty eyes of 30 patients with POAG who had a unilateral ERM were analyzed; 60 nonglaucomatous eyes of 30 patients with a unilateral ERM also were recruited in this institutional cross-sectional study. Patients underwent swept-source (SS) optical coherence tomography (OCT) imaging and visual field testing. Intraindividual differences in the SS-OCT retinal nerve fiber layer (RNFL) disc cupping area measurements and visual field outcomes were analyzed in the two groups. RESULTS. In patients with POAG, the mean circumpapillary RNFL thickness in the eyes with an ERM was 75.6 6 16.5 lm superiorly and 71.8 6 26.0 inferiorly compared with the fellow eyes without an ERM (87.2 6 23.6 lm, P ¼ 0.0061 and 81.3 6 27.7 lm, P ¼ 0.034, respectively). The areas of disc cupping and cup-to-disc ratio seen on OCT horizontal and vertical B-scans were larger in eyes with an ERM than in the fellow eyes without ERM (P ¼ 0.0004 and P ¼ 0.0011, respectively). The average mean deviations were À11.6 6 7.5 dB in the ERM group and À8.19 6 6.4 dB in the group with no ERM (P ¼ 0.029). Eyes with an ERM received more antiglaucoma eye drops (P ¼ 0.018). Those differences were not seen between eyes with an ERM or fellow eyes in patients without glaucoma. CONCLUSIONS. The presence of an ERM can be a potential risk factor for unilateral severity in eyes with POAG.

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Effect of peripapillary retinoschisis on retinal nerve fibre layer thickness measurement in glaucomatous eyes

Abstract: Transient increase in RNFL thickness as determined by OCT was observed in glaucomatous eyes with peripapillary retinoschisis. Caution is warranted when interpreting the RNFL thickness measurement in eyes with peripapillary retinoschisis.

Cited by 31 publications

References 20 publications

Wide-Field En Face Swept-Source Optical Coherence Tomography Features of Extrafoveal Retinoschisis in Highly Myopic Eyes

Wide-Field En Face Swept-Source Optical Coherence Tomography Features of Extrafoveal Retinoschisis in Highly Myopic Eyes

Peripapillary retinal splitting visualized on OCT in glaucoma and glaucoma suspect patients

Cross-Sectional Imaging Analysis of Epiretinal Membrane Involvement in Unilateral Open-Angle Glaucoma Severity

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