Effect of Peritoneal Dialysis on Plasma Levels of Ascorbic Acid

The peritoneal clearance and peritoneal transfer of oxalic acid, vitamin C, and vitamin B6 in 32 patients during continuous ambulatory peritoneal dialysis (CAPD) using peritoneal dialysis solutions containing 1.5% or 2.5% glucose were examined. The plasma level of oxalic acid was significantly elevated in all patients, plasma vitamin C was in the normal range or in the upper margin of the normal range, and plasma vitamin B6 was in the normal range. The peritoneal clearance of oxalic acid was significantly lower, and the peritoneal clearance of vitamin B6 was the lowest in comparison to the peritoneal clearance of urea. With the exception of vitamin B6, the peritoneal clearance and peritoneal transfer of the examined parameters increased using the dialysis solution containing 2.5% glucose. We found direct relationships between the plasma levels of oxalic acid and creatinine as well as plasma vitamin C and between the peritoneal transfer of oxalic acid and the peritoneal transfer of vitamin C as well as vitamin B6. The significant hyperoxalemia of our patients was found to persist despite the relatively high peritoneal transfer of oxalic acid during CAPD. These results suggest that CAPD is not a method effective enough for permanent reduction of the plasma levels of oxalic acid.

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“…The values of the mean peritoneal clearances of vitamin C and oxalic acid were comparable with data in the literature ( 1, 3, 6, 7, 16, 23).…”

Section: Discussionsupporting

confidence: 87%

Peritoneal Clearance and Peritoneal Transfer of Oxalic Acid, Vitamin C, and Vitamin B₆ During Continuous Ambulatory Peritoneal Dialysis

Mydlík

Derzsiová

Svác³

et al. 1998

Artificial Organs

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“…Vitamin C intake is comparable among the nondialyzed and CPD patients and healthy subjects. In ESRD patients, plasma ascorbate level is, therefore, reduced in part due to uremia-associated metabolic derangement and further decreased owing to peritoneal loss of ascorbic acid during PD (8,9). Information on plasma vitamin E in CPD patients is conflicting.…”

Section: Discussionmentioning

confidence: 99%

Increased Oxidative Damage to Peripheral Blood Leukocyte DNA in Chronic Peritoneal Dialysis Patients

Tarng

Chen

Huang

et al. 2002

Journal of the American Society of Nephrology

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Abstract. This study focuses on the extent of oxidative DNA damage in peripheral blood leukocytes of chronic peritoneal dialysis (CPD) patients. 8-Hydroxy 2'-deoxyguanosine (8-OHdG) contents in peripheral leukocyte DNA were measured by an HPLC-electrochemical detection method in 24 age-and sex-matched healthy subjects, 22 nondialyzed patients with advanced renal failure, and 42 CPD patients. Mean 8-OHdG content was the highest in CPD patients, followed by the nondialyzed patients, and then by the healthy subjects (19.4 versus 11.9 versus 8.3/10 6 dG; ANOVA P Ͻ 0.001). In nondialyzed subjects, peripheral leukocyte 8-OHdG contents inversely correlated with renal creatinine clearance (r ϭ Ϫ0.772; P Ͻ 0.001). Deficiency of blood antioxidants in CPD and nondialyzed patients was expressed by the lower plasma levels of ascorbate, cholesterol-standardized ␣-tocopherol and whole-blood reduced glutathione, and the higher levels of whole-blood oxidized glutathione as compared with healthy subjects (ANOVA P Ͻ 0.05). Mean serum ferritin and iron levels and transferrin saturation were higher in the CPD patients than those in the nondialyzed patients and controls (ANOVA P Ͻ 0.05). Flow cytometric analyses of intracellular reactive oxygen species production of peripheral leukocytes showed that spontaneous production by granulocytes, as well as phorbol-12-myristate-13-acetate (PMA)-induced production by granulocytes, lymphocytes and monocytes, were the highest from CPD patients, followed by nondialyzed patients, and then by the healthy subjects (ANOVA P Ͻ 0.05). Forward stepwise multiple regression disclosed that uremia, PD treatment, spontaneous and PMA-induced reactive oxygen species production in leukocytes, and serum iron were the independent determinants of peripheral leukocyte 8-OHdG content (R 2 ϭ 0.769; P Ͻ 0.001). In conclusion, profound increased 8-OHdG levels in peripheral leukocyte DNA occur in the course of chronic renal failure, gradually increase with its progression, and are further exacerbated by PD treatment.

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“…Several investigators showed that PD is accompanied by significant loss of the antioxidant ascorbic acid and therefore, supplementation of this vitamin could be beneficial [ 105 ]. Shah et al reported that oral intake of ascorbic acid resulted in a 45% increase of serum ascorbic acid levels in chronic PD patients [ 106 ].…”

Section: Antioxidant Administration In Pdmentioning

confidence: 99%

Oxidative Stress in Patients Undergoing Peritoneal Dialysis: A Current Review of the Literature

Liakopoulos

Roumeliotis

Gorny

et al. 2017

Oxidative Medicine and Cellular Longevity

100

121

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Peritoneal dialysis (PD) patients manifest excessive oxidative stress (OS) compared to the general population and predialysis chronic kidney disease patients, mainly due to the composition of the PD solution (high-glucose content, low pH, elevated osmolality, increased lactate concentration and glucose degradation products). However, PD could be considered a more biocompatible form of dialysis compared to hemodialysis (HD), since several studies showed that the latter results in an excess accumulation of oxidative products and loss of antioxidants. OS in PD is tightly linked with chronic inflammation, atherogenesis, peritoneal fibrosis, and loss of residual renal function. Although exogenous supplementation of antioxidants, such as vitamins E and C, N-acetylcysteine, and carotenoids, in some cases showed potential beneficial effects in PD patients, relevant recommendations have not been yet adopted in everyday clinical practice.

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Effect of Peritoneal Dialysis on Plasma Levels of Ascorbic Acid

Cited by 24 publications

References 5 publications

Peritoneal Clearance and Peritoneal Transfer of Oxalic Acid, Vitamin C, and Vitamin B₆ During Continuous Ambulatory Peritoneal Dialysis

Peritoneal Clearance and Peritoneal Transfer of Oxalic Acid, Vitamin C, and Vitamin B₆ During Continuous Ambulatory Peritoneal Dialysis

Increased Oxidative Damage to Peripheral Blood Leukocyte DNA in Chronic Peritoneal Dialysis Patients

Oxidative Stress in Patients Undergoing Peritoneal Dialysis: A Current Review of the Literature

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Effect of Peritoneal Dialysis on Plasma Levels of Ascorbic Acid

Cited by 24 publications

References 5 publications

Peritoneal Clearance and Peritoneal Transfer of Oxalic Acid, Vitamin C, and Vitamin B6 During Continuous Ambulatory Peritoneal Dialysis

Peritoneal Clearance and Peritoneal Transfer of Oxalic Acid, Vitamin C, and Vitamin B6 During Continuous Ambulatory Peritoneal Dialysis

Increased Oxidative Damage to Peripheral Blood Leukocyte DNA in Chronic Peritoneal Dialysis Patients

Oxidative Stress in Patients Undergoing Peritoneal Dialysis: A Current Review of the Literature

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Peritoneal Clearance and Peritoneal Transfer of Oxalic Acid, Vitamin C, and Vitamin B₆ During Continuous Ambulatory Peritoneal Dialysis

Peritoneal Clearance and Peritoneal Transfer of Oxalic Acid, Vitamin C, and Vitamin B₆ During Continuous Ambulatory Peritoneal Dialysis