Effect of Peritoneal Dialysis on Serum Concentrations of Three Drugs Commonly Used in Pediatric Patients

Abstract

The use of peritoneal dialysis in young infants bears the theoretical advantage that the relative size of their peritoneal surface area is twice that of adults. The movement of drugs across the peritoneum is affected by the physiochemical properties of the drug molecules and the pathophysiologic condition of the patient. It is observed that the peritoneal dialysis clearances of phénobarbital, amikacin and cefazolin in infants were 1.07-1.33,0.54-0.86 and 0.40-1.02 ml/min, respectively. The dosage determination in the dialysis patients receiving these drugs is discussed.

Effect of Ultrafiltration on Peritoneal Dialysis Drug Clearances

“…Although only theophyl line, phénobarbital and tobramycin were studied, the results may probably apply to other drugs within this molecular weight range when used in patients receiving acute intermittant peritoneal dialysis. However, one should always be aware that drugs are being removed by peritoneal dialysis to var ious extents according to the agents' physico chemical properties and the dialysis tech nique [8][9][10]. Judicious monitoring of the pharmacological effect is always neccessary to maintain high quality of patient care.…”