Effect of peritonitis on mitochondrial respiration

Decker, G.A.; Daniel, A; Blevings, Shirley; MacLean, Lloyd D.

doi:10.1016/0022-4804(71)90093-x

Cited by 25 publications

(7 citation statements)

References 7 publications

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“…Rats and mice were most often studied. The effects of LPS and faecal peritonitis/CLP on mitochondria are summarized in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Effects of sepsis on mitochondrial function remain controversial. Both impaired and increased mitochondrial respiration were reported already in the early studies on endotoxin models of sepsis . The presence of differences in mitochondrial function changes between organs and tissues has been established in several species and models – unfortunately, these differences do not follow a consistent pattern.…”

Section: Discussionmentioning

confidence: 97%

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Mitochondrial function in sepsis

Jeger

Djafarzadeh

Jakob

et al. 2013

Eur J Clin Investigation

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“…Rats and mice were most often studied. The effects of LPS and faecal peritonitis/CLP on mitochondria are summarized in Fig.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

Mitochondrial function in sepsis

Jeger

Djafarzadeh

Jakob

et al. 2013

Eur J Clin Investigation

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“…This method allows to control exactly the quantity,species and strain of the chosen bacterium. Peritonitis was produced, according to the bacteriology of human peri tonitis, by pure cultures of E coli [6,15,21,[26][27][28][29][30], B. fragilis [4,6,31 ], and a mixture of both [2. 3.…”

Section: Discussionmentioning

confidence: 99%

Animal Model for Chronic-Abscess-Forming Peritonitis: Histology and Microbiology

Volk¹,

Schneider²,

Dämmrich³

et al. 1990

Eur Surg Res

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Clinical experience gives evidence of the increasing importance of chronic-abscess-forming peritonitis with a general physical impairment in spite of a well-controlled abdominal situation. The number of unsolved problems led us to develop a standardized and reproducible experimental animal model, using Wistar rats. We induced peritonitis by intra-peritoneal injection of a mixture containing a capsulated strain of Bacteroides fragilis and DEV agar. The histologic changes in the parietal and visceral peritoneum, lymphnodes and liver were recorded in the course of the disease. The data largely correlate with those recorded in human peritonitis. Bacteriologic examinations gave evidence of bacteria passing through the intestinal wall into the abdomen. This is the first model for peritonitis which is defined by its histological and bacteriological course. It enables one to examine pathophysiological problems and the consequences of harm and stress for the course of the disease.

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“…[17], Injection of living bacteria intravenously [1,5,8,[15][16][17] or intraperitoneally [3,6,14,19] together with adjuvant substances causes such a heavy exposure to bacteria that the ani mals die almost momentarily. Other methods like ligation of the cecum with or without puncture [4,18,23,27] and isolation and devascularization of ileal segments [8.…”

Section: Discussionmentioning

confidence: 99%

“…In order to increase the understanding of the pathophys iology of abdominal abscesses and to facili tate studies of various treatment modalities, there is a growing demand for a reproducible small-animal model. The methods used so far have included puncture and ligation of the cecum [4,18,23,25], isolation and devascu larization of an ileal segment [8,10] as well as injection of endotoxin [7,9,13,20,21.24] or intravenous [1,5,8,[15][16][17] or intraperito neal [3,6,14,19] challenge with living bacte ria. Most of these studies have a death rate of 80-100% within 48 h which make the meth ods less suitable for pathophysiological stud ies.…”

Section: Introductionmentioning

confidence: 99%

Standardized Intraabdominal Abscess Formation with Generalized Sepsis: Pathophysiology in the Rat

Hansson¹,

Alwmark²,

Christensen

et al. 1985

Eur Surg Res

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Gelatine capsules containing Escherichia coli and Bacteroides fragilis in a standardized mixture with rat colonic content and barium sulfate were implanted intraabdominally into rats. Capsules of 0.75 g gave approximately 50% mortality whereas 0.35 and 1.10 g caused no or 100% mortality, respectively. In subsequent experiments, using the 0.75 g capsule, all animals became ill with signs of tachypnea, piloerection, low physical activity and hypersecretion of saliva 6–8 h after the implantation. The animals reduced their water and food intake substantially and the body weight decreased. A significant reduction in blood pressure, glucose and leukocyte and platelet counts was found 12 h after challenge. Blood cultures obtained at 12, 24, 48 and 60 h all grew E. coli but none B. fragilis. Succumbed animals revealed diffuse peritonitis with growth of E. coli and B. fragilis at autopsy, whereas surviving animals showed abscess formation at investigation on day 8 after challenge. It was concluded that the model closely resembled intraabdominal abscess formation with sepsis in man.

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Effect of peritonitis on mitochondrial respiration

Cited by 25 publications

References 7 publications

Mitochondrial function in sepsis

Mitochondrial function in sepsis

Animal Model for Chronic-Abscess-Forming Peritonitis: Histology and Microbiology

Standardized Intraabdominal Abscess Formation with Generalized Sepsis: Pathophysiology in the Rat

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