Effect of permeation enhancers on the release and permeation kinetics of Lincomycin hydrochloride gel formulations through mouse skin

Panigrahi, Lalatendu; Ghosal, Shreya; Pattnaik, Snigdha; Maharana, Laxmidhar; Barik, B. B.

doi:10.4103/0250-474x.25716

Cited by 37 publications

(22 citation statements)

References 18 publications

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“…Dimethylsulfoxide and propylene glycol are reported to be the two best permeation enhancers (Panigrahi et al, 2006). Since DMSO reported to causes skin erosion we have used propylene glycol as permeation enhancer in the preparation of the gel formulation (Walker, Smith, 1996).…”

Section: Formulation and Evaluation Of Topical Herbal Gelmentioning

confidence: 99%

Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model

Rajasekaran

Govindarjan

Arivukkarasu

2016

Braz. J. Pharm. Sci.

125

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The objective of the study is to formulate and evaluate a topical herbal gel containing Cardiospermum halicacabum and Vitex negundo leaf extracts for their anti-arthritic activity in rats. Twelve herbal gel formulations were prepared using 1.5% of gelling agents carbopol 934 (F1-F6) and carbopol 940 (F6-F12) and they were evaluated for physical appearance, net content, viscosity, extrudability, pH, spreadability, in vitro diffusion profile and primary skin irritation tests. The stability study for the topical herbal gel formulation was done as per ICH guidelines and anti-arthritic activity was evaluated by Freund's Complete Adjuvant (FCA) induced arthritis method. Assessment of body weight, paw volume, hematological and biochemical parameters, histopathological examination and In vitro determination of serum biomarkers were also carried out. Formulated gels were homogenous, stable and complied with the guidelines. Among the formulations, F4 showed better release (98.4 %) characteristics than other formulations. No erythema or edema was observed in the skin irritation test confirming the gel was nontoxic and safe. Topical application of the herbal gel F4 containing carbopol 934 displayed significant (p < 0.001) anti-arthritic activity compared to diseased rats. Reduction in paw volume, no agglutination in C -reactive protein and rheumatic factor, reduction in TNFα level, regaining of normal hematological, and biochemical parameters, reduction in spleen and thymus weight and histopathological examination supported the anti-arthritic activity of the gel formulation.Uniterms: Arthritis/treatment/herbal gel. Cardiospermum halicacabum/topical herbal gel. Vitex negundo/ topical herbal gel. Medicinal plants/arthritis.

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Section: Formulation and Evaluation Of Topical Herbal Gelmentioning

confidence: 99%

Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model

Rajasekaran

Govindarjan

Arivukkarasu

2016

Braz. J. Pharm. Sci.

125

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“…Rollback was prevented using clamp. The cap was removed and gel extruded until the pressure was degenerated (Panigrahi et al 2006;Srisombat et al 2005;Dave et al 2010;Hathout et al 2007). …”

Section: Extrudabilitymentioning

confidence: 99%

“…The in vitro drug release was carried out in triplicate for each preparation and expressed as Mean ± SD., and then the cumulative drug release (%CDR) was calculated and a plot of time versus %CDR was constructed and shown graphically. In vitro skin permeation studies were conducted for all liposome formulations and reported (Panigrahi et al 2006;Sezer et al 2004;Agarwal et al 2014).…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Herbal liposome for the topical delivery of ketoconazole for the effective treatment of seborrheic dermatitis

et al. 2017

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The aim of the present study was to develop liposomal gel containing ketoconazole and neem extract for the treatment of seborrheic dermatitis in an effectual means. Azoles derivatives that are commonly used to prevent superficial fungal infections include triazole category like itraconazole. These drugs are available in the form of oral dosage that required a long period of time for treatment. Ketoconazole is available in the form of gel but is not used with any herbal extract. Neem (Azadirachta indica) leaves show a good anti-bacterial and anti-fungal activity and have great potential as a bioactive compound. The thin film hydration method was used to design an herbal liposomal preparation. The formulation was further subjected to their characterization as particle size, zeta potential, entrapment efficiency, % cumulative drug release, and anti-fungal activity and it was also characterized by the mean of their physicochemical properties such as FTIR, SEM, DSC, TGA, and AFM. The results show that the formulation of liposomes with neem extract F12 were found to be optimum on the basis of entrapment efficiency in the range 88.9 ± 0.7%, with a desired mean particle size distribution of 141.6 nm and zeta potential -45 mV. The anti-fungal activity of liposomal formulation F12 was carried out against Aspergillus niger and Candida tropicalis by measuring the inhibition zone 8.9 and 10.2 mm, respectively. Stability of optimized formulation was best seen at refrigerated condition. Overall, these results indicated that developed liposomal gel of ketoconazole with neem extract could have great potential for seborrheic dermatitis and showed synergetic effect for the treatment.

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“…Based on the high drug solubility, which was important to achieve, benzyl alcohol, oleic acid, and lemon oil were selected for preparation of the CTM microemulsions (24). Although the drug had a relative low solubility in IPM compared to other oils, it was also selected for the preparation of microemulsions due to its well-known permeation-enhancing property (25) and biocompatibility (26).…”

Section: Determination Of Saturation Solubility Of Ctm In Different Oilsmentioning

confidence: 99%

Formulation, Characterization, and Clinical Evaluation of Microemulsion Containing Clotrimazole for Topical Delivery

et al. 2011

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Abstract. The objective of the present study was to formulate and evaluate microemulsion systems for topical delivery of clotrimazole (CTM). The solubility of CTM in various oils was determined to select the oil phase of the microemulsion systems. Pseudoternary phase diagrams were constructed to identify the area of microemulsion existence. Five CTM microemulsion formulations (M1-M5) were prepared and evaluated for their thermodynamic stability, pH, refractive index, droplet size, viscosity, and in vitro release across cellulose membrane. Among the prepared microemulsion formulations, M3 (lemon oil/ Tween 80/n-butanol/water) and M4 (isopropyl myristate/Tween 80/n-butanol/water) microemulsion systems were found to be promising according to their physical properties and CTM cumulative percentage release. Gel form of M3 and M4 were prepared using 1% Carbopol 940 as the hydrogel matrix. Both formulations were evaluated in the liquid and gel forms for drug retention in the skin in comparison to the marketed CTM topical cream and their stability examined after storage at 40°C for 6 months. Microemulsion formulations achieved significantly higher skin retention for CTM over the CTM cream. Stability studies showed that M4 preparations were more stable than M3. The in vitro antifungal activity of M4 against Candida albicans was higher than that of the conventional cream. Moreover, clinical evaluation proved the efficacy and tolerability of this preparation in the treatment of various topical fungal infections.

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Effect of permeation enhancers on the release and permeation kinetics of Lincomycin hydrochloride gel formulations through mouse skin

Cited by 37 publications

References 18 publications

Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model

Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model

Herbal liposome for the topical delivery of ketoconazole for the effective treatment of seborrheic dermatitis

Formulation, Characterization, and Clinical Evaluation of Microemulsion Containing Clotrimazole for Topical Delivery

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