Effect of permethrin plus antioxidants on locomotor activity and striatum in adolescent rats

Nasuti, Cinzia; Falcioni, Maria Letizia; Nwankwo, Innocent Ejike; Cantalamessa, Franco; Gabbianelli, Rosita

doi:10.1016/j.tox.2008.07.049

Cited by 48 publications

(30 citation statements)

References 28 publications

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“…One day after completion of the water maze task, controls (N = 7) and PERM (N = 7) treated rats were tested for their locomotor behavior using automated locomotor activity boxes (Med Associates, VT 05478) as previously reported (Nasuti et al, 2008). Locomotor activity was recorded for 10 min, starting 1 min after placing the animal in the test cage.…”

Section: Locomotor Activitymentioning

confidence: 99%

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

et al. 2013

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a b s t r a c tPesticide exposure during brain development could represent an important risk factor for the onset of neurodegenerative diseases. Previous studies investigated the effect of permethrin (PERM) administered at 34 mg/kg, a dose close to the no observable adverse effect level (NOAEL) from post natal day (PND) 6 to PND 21 in rats. Despite the PERM dose did not elicited overt signs of toxicity (i.e. normal body weight gain curve), it was able to induce striatal neurodegeneration (dopamine and Nurr1 reduction, and lipid peroxidation increase). The present study was designed to characterize the cognitive deficits in the current animal model. When during late adulthood PERM treated rats were tested for spatial working memory performances in a T-maze-rewarded alternation task they took longer to choose for the correct arm in comparison to age matched controls. No differences between groups were found in anxiety-like state, locomotor activity, feeding behavior and spatial orientation task. Our findings showing a selective effect of PERM treatment on the T-maze task point to an involvement of frontal cortico-striatal circuitry rather than to a role for the hippocampus. The predominant disturbances concern the dopamine (DA) depletion in the striatum and, the serotonin (5-HT) and noradrenaline (NE) unbalance together with a hypometabolic state in the medial prefrontal cortex area. In the hippocampus, an increase of NE and a decrease of DA were observed in PERM treated rats as compared to controls. The concentration of the most representative marker for pyrethroid exposure (3-phenoxybenzoic acid) measured in the urine of rodents 12 h after the last treatment was 41.50 g/L and it was completely eliminated after 96 h.

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Section: Locomotor Activitymentioning

confidence: 99%

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

et al. 2013

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“…Automated locomotor activity boxes (Med Associates, VT 05478) were used to quantify the behavioural activity as previously reported (18). Each animal was placed in the activity box and spontaneous locomotor activity parameters were monitored.…”

Section: Measurement Oflocomotor Activitymentioning

confidence: 99%

Effects and Trimethyltin on Hippocampal Dopaminergic Markers and Cognitive Behaviour

Mignini

Nasuti

Artico

et al. 2012

Int J Immunopathol Pharmacol

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The triorganotin compound trimethyltin (TMT) is a highly toxic molecule which has a great impact on human health. The aim of this study was to investigate the specific alteration of dopamine receptors and transporters in the hippocampus of TMT-treated rats. The TMT-treated group showed impaired spatial reference memory in a Morris water maze task compared to the control group, whereas memory consolidation tested 24 hours after the last training session was preserved. In the open field, TMT-treated rats showed a decrease in time spent in rearing episodes reflecting a lower interest to explore a novel environment. In the hippocampal area of the TMT-treated group, we observed a reduction in neuronal viability accompanied by a significant decrease in the expression of the dopamine receptors (D1 and D2), and dopamine transporters (DAT, VMAT1 and VMAT2). A less pronounced reduction was observed for D3 and D5 while D4 did not change. These data were confirmed by RT-PCR analysis. The present study on TMT-induced neurodegeneration highlights the link between hippocampal asset of dopamine receptors and transporters and the impaired performance of rats in a spatial reference memory task.

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“…Another study report showed that supplementation with CoQ 10 led to increased erythrocyte GSH concentration in diabetic rats (25). Nevertheless, Nasuti et al (69) stated that supplementation with Vitamin E + CoQ 10 could not prevent the reduction in GSH in adolescent rats. This effect could be related to the dual activity of CoQ 10 that can act as antioxidant but also as pro-oxidant.…”

Section: Discussionmentioning

confidence: 99%

Effects of CoQ10 supplementation and swimming training on exhaustive exercise-induced oxidative stress in rat heart

Okudan¹,

Revan²,

Balcı³

et al. 2012

BLL

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This study examined the combined effects of swimming training and coenzyme Q 10 (CoQ 10 ) supplementation on exhaustive exercise-induced oxidative stress in rat heart. The study was carried out with 4-monthold young adult male Wistar rats. Sixty four rats were divided mainly into two groups: trained and control. Each group was further divided into four subgroups: rest, exhausted, rest with CoQ 10 , exhausted with CoQ 10 . The training program consisted of swimming one hour each day, fi ve days a week, for six weeks. At the end of sixth week, rats in exhausted exercise group were forced to swim until exhaustion and then they were immediately sacrifi ced, while rats in rest group were sacrifi ced at rest. Training alone or in combination with CoQ 10 supplementation reduced to increasing MDA levels due to exhaustive exercise in rat heart (p<0.05). The trained-rest with CoQ 10 group showed lower 8-OHdG levels than the control-rest with CoQ 10 group. Exhaustive exercise effect was signifi cant on SOD activity. Exhaustive exercise increased GSH levels in control groups while decreased GSH levels in training groups (p<0.05). In conclusion, the results suggest that CoQ 10 supplementation combined with training may inhibit lipid peroxidation and DNA damage in the heart tissue. Also, it can be said that SOD activity and GSH levels were not infl uenced by CoQ 10 supplementation (Fig. 4

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Effect of permethrin plus antioxidants on locomotor activity and striatum in adolescent rats

Cited by 48 publications

References 28 publications

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

Effects and Trimethyltin on Hippocampal Dopaminergic Markers and Cognitive Behaviour

Effects of CoQ10 supplementation and swimming training on exhaustive exercise-induced oxidative stress in rat heart

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