Effect of Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 Alpha Variants on Spontaneous Clearance and Fibrosis Progression during Hepatitis C Virus Infection in Moroccan Patients

Roles of peroxisome proliferator‐activated receptors in hepatocellular carcinoma

“…MiR‐27a induces the proliferation of HCC cells by targeting the 3′‐untranslated region of PPARγ 77 . The overexpression of PPARγ coactivator 1‐alpha (PPARγC1α) promotes HCC apoptosis, indicating that it might be a potential HCC therapeutic target 78 …”

“… 77 The overexpression of PPARγ coactivator 1‐alpha (PPARγC1α) promotes HCC apoptosis, indicating that it might be a potential HCC therapeutic target. 78 …”

Update on the association between non‐alcoholic fatty liver disease andHelicobacter pyloriinfection

“…In this regard, for instance, a connection between Hp-related CagA in hepatocytes and hepatitis C virus (HCV) is associated with progression of HCV-related chronic hepatitis to cirrhosis and its complications 36 and NAFLD induced by HCV have been connected with its accelerated progression. 37 Moreover, some data indicate cagA gene presence in liver samples from patients with chronic liver disease or hepatocellular carcinoma. 38,39 Viewing aforementioned data, we can consider that Hp CagA PAI, VacA or BabA may contribute to Hp-related pathophysiology of chronic liver diseases including NAFLD and thus, further research is needed to elucidate this speculation.…”

“…Relative data indicate that beyond gastric epithelial cells, Hp internalisation in hepatocytes is also dependent on CagA PAI, vacuolating cytotoxin A (VacA) or blood‐antigen binding protein A (BabA) adhesin status 34 ; proteins encoded by the cagA, vacA and babA2 genes determine the pathogenicity of Hp 35 and invasion and stay of Hp within hepatocytes could be a potential strategy of Hp to evade host immuno‐reaction leading to pathological changes of hepatocytes 34 potentially observed in liver diseases, including NAFLD. In this regard, for instance, a connection between Hp ‐related CagA in hepatocytes and hepatitis C virus (HCV) is associated with progression of HCV‐related chronic hepatitis to cirrhosis and its complications 36 and NAFLD induced by HCV have been connected with its accelerated progression 37 . Moreover, some data indicate cagA gene presence in liver samples from patients with chronic liver disease or hepatocellular carcinoma 38,39 .…”