Effect of personalized moderate exercise training on Wistar rats fed with a fructose enriched water

Abstract

BackgroundMetabolic Syndrom has become a public health problem. It mainly results from the increased consumption of fat and sugar. In this context, the benefits of personalized moderate exercise training were investigated on a metabolic syndrome male wistar rat model food with fructose drinking water (20–25% w/v). Different markers including body weight, metabolic measurements, blood biochemistry related to metabolic syndrome complications have been evaluated.MethodsMale Wistar rats were randomly allocated to 4 groups: control (sedentary (C, n = 8) and exercise trained (Ex, n = 8)), fructose fed (sedentary (FF, n = 8) and exercise trained fructose fed rats (ExFF, n = 10)). ExFF and Ex rats were trained at moderate intensity during the last 6 weeks of the 12 weeks-long protocol of fructose enriched water. Metabolic control was determined by measuring body weight, fasting blood glucose, HOMA 2-IR, HIRI, MISI, leptin, adiponectin, triglyceridemia and hepatic dysfunction.ResultsAfter 12 weeks of fructose enriched diet, rats displayed on elevated fasting glycaemia and insulin resistance. A reduced food intake, as well as increased body weight, total calorie intake and heart weight were also observed in FF group. Concerning biochemical markers, theoretical creatinine clearance, TG levels and ASAT/ALAT ratio were also affected, without hepatic steatosis. Six weeks of 300 min/week of moderate exercise training have significantly improved overweight, fasting glycaemia, HOMA 2-IR, MISI without modify HIRI. Exercise also decreased the plasma levels of leptin, adiponectin and the ratio leptin/adiponectin. Regarding liver function and dyslipidemia, the results were less clear as the effects of exercise and fructose-enriched water interact together, and, sometimes counteract each other.ConclusionOur results indicated that positive health effects were achieved through a personalized moderate training of 300 min per week (1 h/day and 5 days/week) for 6 weeks. Therefore, regular practice of aerobic physical exercise is an essential triggering factor to attenuate MetS disorders induced by excessive fructose consumption.

The restorative effects of graded intensities of exercise training on the biochemical and nutritional status of obese induced male Wistar rats (Rattus novegicus)

“…The Wistar rats in the HFDS control group (sedentary) had significantly higher body weights and food intake than those in the training exercise, which is consistent with the findings of Dupas et al (2018). This significant lower body weight in exercise-trained rats could be attributed to the reduction of the amount of adipose tissue, resulting in decreased generation of sex hormones, glucose, and leptin, increased levels of appetite-suppressing neuropeptide hormones such as nesfatin-1 and peptide YY, and negative energy and fat balance linked with increased energy expenditure and fat oxidation during exercise (Speretta et al, 2012).…”

Combination of chronic stress with fructose diet increases AMP-activated protein kinase phosphorylation and affects agouti-related protein and proopiomelanocortin expression in the hypothalamus of male Wistar rats

“…Furthermore, discrepancies between previous studies on males and our current findings might originate from differences in the strain of the experimental animals, since more prominent effects of fructose diet on adiposity were observed in Sprague-Dawley rats (Bocarsly et al, 2010;Crescenzo et al, 2014;Nyakudya et al, 2018;Zubiría et al, 2013). Finally, as recently reviewed by Chan and others (Chan et al, 2021), the concentration of administered fructose solution (ranging from 10% to 60%) (Bursac et al, 2014;de Moura et al, 2009), as well as the treatment duration (Dupas et al, 2018;Chan et al, 2021) and the age of the animals at the beginning of the experiment (suckling, young or adults) (Nyakudya et al, 2018;Ramos et al, 2017) could also be significant factors for the outcome of fructose diet on VAT mass.…”

Moderate-intensity exercise training improves long-term memory in fructose-fed rats

“…Exercise training carried out three days a week, did not affect eating behavior. However, other studies that submitted Wistar rats to five days a week treadmill training had demonstrated exercise effect to lower food intake 33,34 .…”