Effect of PGE1 or PGE2 on PGF2α-induced luteolysis in nonbred ewes

Reynolds, Lawrence P.; Stigler, J.; Hoyer, Gifford L.; Magness, Ronald R.; Huie, J.M.; Huecksteadt, Thomas P.; Whysong, G.; Behrman, Harold R.; Weems, C.W.

doi:10.1016/0090-6980(81)90164-7

Cited by 84 publications

(27 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Administration of PGE-2 into the uterine lumen alone (Giménez & Henricks, 1983;Chenault, 1983) or in combination with oestradiol-17ß (Reynolds, Robertson & Ford, 1983) extends luteal function only slightly beyond the cessation of intrauterine PGE-2 treatments. In addition, systemic progesterone concentrations declined within 12 h after PGE-2 treatment (Giménez & Henricks, 1983) period (Reynolds et al, 1983), suggesting that PGE-2 (plus oestradiol-17ß) will not prevent produc¬ tion and transfer of uterine luteolytic substances, but affects luteal function directly (Marsh, 1970;Henderson, Scaramuzzi & Baird, 1977;Reynolds et al, 1981). Others have reported no effect of intrauterine PGE-2 administration on CL maintenance in cattle (Dalla Porta & Humblot, 1983;Chenault, Van Ravenswaay & Campbell, 1984).…”

Section: Introductionmentioning

confidence: 99%

Proteins secreted by Day-16 to -18 bovine conceptuses extend corpus luteum function in cows

Knickerbocker¹,

Thatcher²,

Bazer³

et al. 1986

Reproduction

176

View full text Add to dashboard Cite

Summary. Corpus luteum function, interoestrous interval and spontaneous uterine PGF-2\g=a\ (PGF) production were evaluated in 9 cyclic Holstein cows (3/group) after intrauterine injections of pooled conceptus secretory proteins, 5\g=b\-pregnan-3\g=a\-ol -20\x=req-\ one, or homologous serum proteins on Days 15\m=.\5 through 21 after oestrus. A significant extension of corpus luteum lifespan and interoestrous interval were detected in cows treated with conceptus secretory proteins compared to the other 2 groups. CL lifespan and interoestrous interval were not different (P > 0\m=.\25) between 5\g=b\-pregnan\x=req-\ 3\g=a\-ol-20-oneand control groups. Evaluation of spontaneous PGF responses suggested that proteins synthesized and secreted by the bovine conceptus accommodate luteal maintenance during early gestation via an attenuation of endometrial PGF production.

show abstract

Section: Introductionmentioning

confidence: 99%

Proteins secreted by Day-16 to -18 bovine conceptuses extend corpus luteum function in cows

Knickerbocker¹,

Thatcher²,

Bazer³

et al. 1986

Reproduction

176

View full text Add to dashboard Cite

show abstract

“…PGF2a is well recognized as the main luteolytic agent in ruminants, whereas PGE2 (PGE2) has luteotropic and luteoprotective properties (Reynold et al 1981, Weems et al 1998. Although both PGE2 and PGF2a are secreted by bovine endometrium throughout the estrous cycle , Murakami et al 2001, the relative proportion of PGE2 and PGF2a secretion is thought to be more important than the absolute amounts of each PG to exert their own physiological effects on the female reproductive function (Murakami et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Regulation of prostaglandin biosynthesis by interleukin-1 in cultured bovine endometrial cells

Tanikawa¹,

Lee²,

Watanabe³

et al. 2008

Journal of Endocrinology

View full text Add to dashboard Cite

Interleukin-1 (IL1) has been shown to be a potent stimulator of prostaglandin (PG) production in bovine endometrium. The aim of the present study was to determine the cell types in the endometrium (epithelial or stromal cells) responsible for the secretion of PGE2 and PGF2a in response to IL1A, and the intracellular mechanisms of IL1A action. Cultured bovine epithelial and stromal cells were exposed to IL1A or IL1B (0 . 006-3 . 0 nM) for 24 h. IL1A and IL1B dose-dependently stimulated PGE2 and PGF2a production in the stromal cells, but not in the epithelial cells. The stimulatory effect of IL1A (0 . 06-3 . 0 nM) on PG production was greater than that of IL1B.The stimulatory actions of IL1A on PG production was augmented by supplementing arachidonic acid (AA). When the stromal cells were incubated with IL1A and inhibitors of phospholipase (PL) C or PLA2 (1 mM; anthranilic acid), only PLA2 inhibitor completely stopped the stimulatory action of IL1A on PG production. Moreover, a specific cyclooxygenase-2 (COX2) inhibitor blocked the stimulatory effect of IL1A on PG production. IL1A (0 . 06 nM) promoted COX2 and microsomal PGE synthase-1 (PGES1) gene and its protein expression. The expression of COX1, PGES2, PGES3, and PGF synthase (PGFS) mRNA was not affected by IL1A in the stromal cells. The overall results indicate that 1) the target of IL1A and IL1B for stimulating both PGE2 and PGF2a production is the stromal cells, 2) IL1A is a far more potent stimulator than IL1B on PG production in stromal cells, 3) the stimulatory effect of IL1A on PG production is mediated via the activation of PLA2 and COX2, and (4) IL1A induced PG production by increasing expressions of COX2 and PGES1 mRNAs and their proteins in bovine stromal cells.

show abstract

“…Conversion function, negative feedback and positive feedback 6-Keto PGF1a and PGE1 have a potential conversion function at conversion Point C. PGF2a and PGE2, respectively, 6-keto PGF1a and PGE1 have antagonistic effects [22,23], although not all research has shown antagonism between PGF2a and PGE2 [24]. PGF2a and PGE2 are linear to a large extent, and 6-keto PGF1a and PGE1 are bell-shaped in the concentration-effect curve.…”

Section: Prostaglandinsmentioning

confidence: 99%

CRPS: A contingent hypothesis with prostaglandins as crucial conversion factor

Veen¹

2015

Medical Hypotheses

View full text Add to dashboard Cite

Effect of PGE1 or PGE2 on PGF2α-induced luteolysis in nonbred ewes

Cited by 84 publications

References 51 publications

Proteins secreted by Day-16 to -18 bovine conceptuses extend corpus luteum function in cows

Proteins secreted by Day-16 to -18 bovine conceptuses extend corpus luteum function in cows

Regulation of prostaglandin biosynthesis by interleukin-1 in cultured bovine endometrial cells

CRPS: A contingent hypothesis with prostaglandins as crucial conversion factor

Contact Info

Product

Resources

About