Effect of pharmacists’ interventions on health outcomes of children with asthma: A systematic review

Macêdo, Luana Andrade; Silva, Rafaella de Oliveira Santos; Silvestre, Carina Carvalho; Alcântara, Thaciana dos Santos; Simões, Sílvia de Magalhães; Lyra, Divaldo Pereira de

doi:10.1016/j.japh.2021.01.002

Cited by 6 publications

(5 citation statements)

References 103 publications

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“…It is worth noting that the studies included were very heterogeneous in terms of their design and methodology, outcome measures and setting; thus, conducting a meta‐analysis on the effect of different pharmaceutical interventions was not feasible and not intended as we anticipated from the outset. This could be attributed to the fact that the recent shift to clinically orientated pharmacy services and lack of clear pharmaceutical care practice standards, in the region, had an effect on reproducibility to compare effectiveness 83 . Therefore, the findings should be interpreted with caution.…”

Section: Discussionmentioning

confidence: 97%

“…This could be attributed to the fact that the recent shift to clinically orientated pharmacy services and lack of clear pharmaceutical care practice standards, in the region, had an effect on reproducibility to compare effectiveness. 83 Therefore, the findings should be interpreted with caution. Other limitations included not checking additional sources of grey literature such as theses and conference proceedings.…”

Section: Discussionmentioning

confidence: 99%

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A systematic review on the impact of pharmacist‐provided services on patients’ health outcomes in Arab countries

El-Awaisi

Al-Shaibi

Al-Ansari

et al. 2022

Clinical Pharmacy Therapeu

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

A systematic review on the impact of pharmacist‐provided services on patients’ health outcomes in Arab countries

El-Awaisi

Al-Shaibi

Al-Ansari

et al. 2022

Clinical Pharmacy Therapeu

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“…The role of the pharmacist in the management of asthma is already well documented in the literature [63,64]. Studies have shown that the most common pharmacists' interventions on health outcomes in patients with asthma were patient counseling [65,66]. Thus, since patient counseling is a core component of the drug dispensing, the service may contribute to the care of patients with asthma.…”

Section: Discussionmentioning

confidence: 99%

Does drug dispensing improve the health outcomes of patients attending community pharmacies? A systematic review

Pizetta

Raggi

Rocha

et al. 2021

BMC Health Serv Res

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Background Drug dispensing is a clinical pharmacy service that promotes access to medicines and their rational use. However, there is a lack of evidence for the impact of drug dispensing on patients’ health outcomes. Thus, the purpose of this study was to assess the influence of drug dispensing on the clinical, humanistic, and economic outcomes of patients attending community pharmacies. Methods A systematic literature search was performed in April 2021 using PubMed, Web of Science, Cochrane Library, LILACS, and Open Thesis. Two reviewers screened titles, abstracts, and full-text articles according to the eligibility criteria. Methodological quality was assessed using tools from the Joanna Briggs Institute, and the literature was synthesized narratively. Results We retrieved 3,685 articles and included nine studies that presented 13 different outcomes. Regarding the design, they were cross-sectional (n = 4), randomized clinical trials (n = 4), and quasi-experimental (n = 1). A positive influence of drug dispensing on health outcomes was demonstrated through six clinical, four humanistic and three economic outcomes. Eight studies (88,9 %) used intermediate outcomes. The assessment of methodological quality was characterized by a lack of clarity and/or lack of information in primary studies. Conclusions Most articles included in this review reported a positive influence of drug dispensing performed by community pharmacists on patients’ health outcomes. The findings of this study may be of interest to patients, pharmacists, decision makers, and healthcare systems, since they may contribute to evidence-based decision-making, strengthening the contribution of community pharmacists to health care. Trial registration Registration: PROSPERO CRD42020191701.

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“…However, few hydroxyurea adherence interventions have addressed systematic hydroxyurea adherence barriers, such as those that prevent patients from filling their hydroxyurea (e.g., limited access to pharmacies, challenges with prior authorizations, difficulty identifying pharmacies with the ability to dispense the liquid hydroxyurea formulation, and pharmacies that provide automatic refills). One strategy that may hold significant promise, as demonstrated in other chronic diseases such as cystic fibrosis, for increasing medication adherence is the involvement of clinical pharmacists as an integral part of the care team for children with SCA 40–47 . The impact of clinical pharmacists has been described, with outcomes including improved hydroxyurea dose escalation rate, immunization completion rates, and screening for complications such as microalbuminuria and sickle cell retinopathy 48 .…”

Section: Discussionmentioning

confidence: 99%

“…One strategy that may hold significant promise, as demonstrated in other chronic diseases such as cystic fibrosis, for increasing medication adherence is the involvement of clinical pharmacists as an integral part of the care team for children with SCA. [40][41][42][43][44][45][46][47] The impact of clinical pharmacists has been described, with outcomes including improved hydroxyurea dose escalation rate, immunization completion rates, and screening for complications such as microalbuminuria and sickle cell retinopathy. 48 However, data related to the addition of a pharmacist to the care of children with SCA are currently lacking.…”

Section: Discussionmentioning

confidence: 99%

Adherence to hydroxyurea and clinical outcomes among children with sickle cell anemia

Reeves

Dombkowski

Peng

et al. 2023

Pediatric Blood & Cancer

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Objective Hydroxyurea lowers the incidence of vaso‐occlusive pain crises (VOC) and acute chest syndrome (ACS) among children with sickle cell anemia (SCA). Our objective was to assess the relationship between levels of adherence to hydroxyurea and clinical outcomes among children and adolescents with SCA. Methods This retrospective cohort study included Medicaid data (2005–2012) from Florida, Illinois, Louisiana, Michigan, South Carolina, and Texas. The study population consisted of children 1–17 years old with SCA enrolled in Medicaid for 3 years. Among children that initiated hydroxyurea, the medication possession ratio (MPR) was calculated as the proportion of days covered by hydroxyurea. Six months after initiation of hydroxyurea, clinical outcomes were assessed through the end of the study period: numbers of VOC‐related inpatient admissions and emergency department visits, and encounters for ACS. Multivariable Poisson models were used to predict outcomes by MPR quartile adjusting for previous healthcare utilization, state, and age. Results Hydroxyurea was initiated by 515 children. The median MPR was 0.53 (interquartile range = 0.3–0.8). The annual median number of visits was 0.0 for ACS, 1.3 for VOC‐related emergency department, and 1.4 for VOC‐related inpatient admissions. For each outcome, the highest quartile of MPR had the lowest predicted count; this difference was significant for ACS visits when compared with the lowest quartile of MPR. Conclusion This study demonstrated a high level of adherence (>75%) was essential to achieve a lower incidence of common negative clinical outcomes. Further, moderate and severe hydroxyurea nonadherence may be more common than previously appreciated among children, emphasizing the importance of developing and testing innovative strategies to increase adherence.

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Effect of pharmacists’ interventions on health outcomes of children with asthma: A systematic review

Cited by 6 publications

References 103 publications

A systematic review on the impact of pharmacist‐provided services on patients’ health outcomes in Arab countries

A systematic review on the impact of pharmacist‐provided services on patients’ health outcomes in Arab countries

Does drug dispensing improve the health outcomes of patients attending community pharmacies? A systematic review

Adherence to hydroxyurea and clinical outcomes among children with sickle cell anemia

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