Effect of pharmacological agents on relapse following orthodontic tooth movement:

Abstract

Objectives: To investigate and synthesize systematically the evidence from animal studies pertaining to the effect of pharmacological agents on tooth movement relapse following cessation of orthodontic force application. Materials and Methods: An electronic search was conducted in seven online databases (including gray sources) without restrictions until the third week of April 2019, followed by a hand search in the reference lists of eligible articles. Controlled animal studies investigating the effect of pharmacological agents on tooth movement relapse following orthodontic treatment were selected. Relevant data were extracted from eligible studies and the risk of bias assessment was done using SYRCLE's risk of bias tool. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation tool. Results: The search identified 2354 records, of which 7 studies were deemed eligible for inclusion in the qualitative synthesis, with the majority presenting an unclear risk of bias. Orthodontic relapse was shown to decrease with the administration of pamidronate disodium, atorvastatin, aspirin, and chemically modified tetracycline-3. Inconsistent effects on relapse were observed after the use of simvastatin. The overall quality of retrieved evidence was assessed as low at best.Conclusions: The available evidence shows that the investigated pharmacological agents may demonstrate variable effects on tooth movement relapse following cessation of orthodontic force. Additional evidence of higher quality is required to draw definitive conclusions on their effects and to make potential recommendations for clinical application. (Angle Orthod. 2020;90:598-606.) Although planned, analyses for small-study effects, publication bias, or exploratory subgroup analyses were not feasible because of the inadequate number of studies. The quality of evidence

Effect of vitamin D deficiency on postorthodontic relapse: An animal study

“…One of the most important concerns in orthodontics is the retention of the teeth after orthodontic treatment (Proffit et al, 2019). Previous research used local applications of biological agents, such as statins, strontium, bisphosphonates, tetracycline, raloxifene, and calcitonin, to decrease the amount of relapse (Al-Duliamy et al, 2015;Alnajar & Al Groosh, 2020;Azami et al, 2020;Hudson et al, 2012;Veginadu et al, 2020;Vieira et al, 2019). However, local applications have some drawbacks, such as the short half-life of the agents, which requires multiple applications, and health-related issues associated with prolonged administration (Arqub et al, 2021).…”

“…One of the most important concerns in orthodontics is the retention of the teeth after orthodontic treatment (Proffit et al, 2019 ). Previous research used local applications of biological agents, such as statins, strontium, bisphosphonates, tetracycline, raloxifene, and calcitonin, to decrease the amount of relapse (Al‐Duliamy et al, 2015 ; Alnajar & Al Groosh, 2020 ; Azami et al, 2020 ; Hudson et al, 2012 ; Veginadu et al, 2020 ; Vieira et al, 2019 ).…”

Periodontal Ligament Stem Cell-Derived Extracellular Vesicles Enhance Tension-Induced Osteogenesis

“…In this regard, enhancing osteogenesis on the tension side has great significance in ensuring OTM efficiency and maintaining alveolar bone homeostasis. Currently, the pro-osteogenic effects of some pharmacologic agents used for bone metabolism disorders, including simvastatin, raloxifene, and osteoprotegerin, have been investigated in animal OTM models. , However, except for the reported different therapeutic doses and controversial therapeutic effects, treatment with these pharmacologic agents adversely affects tooth movement . Therefore, developing novel approaches to promote osteogenesis on the tension side is essential for enhancing orthodontic treatment.…”

Could medications and biologic factors affect post‐orthodontic tooth movement changes? A systematic review of animal studies

“…24,25 To the best of our knowledge, there has not been any systematic review comprehensively elaborating the potential effect of medications and other biologic factors on the rate of relapse following active orthodontic tooth movement, as the available studies have not managed to identify and appraise all the pertinent information. 26…”