Effect of phenothiazine neuroleptic drugs and tricyclic antidepressants on phosphodiesterase activity in rat cerebral cortex

Janiec, W; Kroczak-Dziuba, K; Herman, Zbigniew S.

doi:10.1007/bf00428921

Cited by 8 publications

(2 citation statements)

References 23 publications

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“…Although the authors discuss a complicated mechanism to account for this finding, the possibility should perhaps also be considered that the potentiation resulted from the inhibition of phosphodiesterase (see Janiec, Korczak-Dziuba & Herman, 1974;Amer & Krieghbaum, 1975).…”

Section: Discussionmentioning

confidence: 99%

“…It may be relevant here that Bevan, Bradshaw & Szabadi (1975) have described the potentiation of neuronal responses to acetylcholine and carbachol by the tricyclic antidepressant compounds imipramine and desipramine. Although the authors discuss a complicated mechanism to account for this finding, the possibility should perhaps also be considered that the potentiation resulted from the inhibition of phosphodiesterase (see Janiec, Korczak-Dziuba & Herman, 1974;Amer & Krieghbaum, 1975).…”

Section: Discussionmentioning

confidence: 99%

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Microiontophoretic studies of the effects of cyclic nucleotides on excitability of neurones in the rat cerebral cortex

Stone

Taylor

1977

The Journal of Physiology

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SUMMARY1. Responses of cerebral cortical neurones to the microiontophoretic application of acetylcholine, noradrenaline, cyclic adenosine 3',5'-monophosphate (cyclic AMP) and cyclic guanosine 3',5'-monophosphate (cyclic GMP) were examined.2. The application of acetylcholine and cyclic GMP to identified pyramidal tract neurones resulted in an increased frequency of firing in a large number of cells. Upon application of both substances to cells which could not be identified as pyramidal tract cells, a reduction in the frequency of spontaneous firing was sometimes observed.3. Careful current controls had no effect on the cells discussed here, indicating that the observed responses were not due to the iontophoretic currents. Also, the electro-osmotic ejection of cyclic GMP (outward current) produced similar changes of cell firing to those which followed iontophoretic application (inward current).4. The microiontophoretic application of atropine resulted in a blockade of acetylcholine responses while leaving responses to cyclic GMP unaffected. This suggests that cyclic GMP was not acting indirectly by releasing acetylcholine from presynaptic endings.5. Ejection of cyclic GMP from solutions containing calcium ions produced responses comparable to those produced by cyclic GMP alone. It

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%