Effect of phenotypic switching on biofilm traits in Candida tropicalis

Moralez, AlaneT.P.; Perini, Hugo Felix; Paulo, Eloiza A.; Furlaneto-Maia, Luciana; Furlaneto, Márcia Cristina

doi:10.1016/j.micpath.2020.104346

Cited by 7 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Confocal microscopy of adhered cells to polystyrene showed that layers of switched strains were thicker than the thinner layer of adhered cells of the original counterpart strain. Other studies reported increased biofilm formation by switched strains of C. tropicalis (França et al 2011;Moralez et al 2014). Biofilms formed by switched strains were thicker than biofilms generated by the original strain.…”

Section: Phenotypic Switchingmentioning

confidence: 86%

“…Biofilms formed by switched strains were thicker than biofilms generated by the original strain. Of note, biofilm cells of switched strains adhered better to polystyrene surfaces than biofilm cells of the parental strain (Moralez et al 2020). Furthermore, phenotypic switching affected filamentous growth (hyphae and pseudohyphae) among adhered and biofilm cells on the polystyrene surface.…”

Section: Phenotypic Switchingmentioning

confidence: 96%

“…Furthermore, phenotypic switching affected filamentous growth (hyphae and pseudohyphae) among adhered and biofilm cells on the polystyrene surface. A switched strain denoted crepe showed greater filamentous growth than that of its clinical strain counterpart (Souza et al 2020b;Moralez et al 2020).…”

Section: Phenotypic Switchingmentioning

confidence: 96%

“…According to these authors, C. tropicalis is capable of undergoing high-frequency phenotypic switching, and more than one strain-specific switching repertoire has been observed in this species. More recently, in vitro studies have demonstrated that distinct isolate-specific switching repertoires occur in clinical isolates of C. tropicalis (França et al 2011;Moralez et al 2014).…”

Section: Phenotypic Switchingmentioning

confidence: 99%

“…Our group has shown that phenotypic switching causes an effect on C. tropicalis adherence and biofilm formation (França et al 2011;Moralez et al 2014Moralez et al , 2020Souza et al 2020b). The increase in switch strains with increased adhesion may impact the ability of these strains to form biofilms.…”

Section: Phenotypic Switchingmentioning

confidence: 99%

See 4 more Smart Citations

Adhesion and biofilm formation by the opportunistic pathogen Candida tropicalis: what do we know?

et al. 2023

Self Cite

View full text Add to dashboard Cite

Candida tropicalis is among the most important Candida species in terms of epidemiology, virulence and resistance. Considering the increase in C. tropicalis incidence and high rates of mortality associated with this species, knowledge of its adhesion and biofilm formation abilities is needed. These traits determine the persistence and survival of yeast on different indwelling medical devices and host sites. C. tropicalis is among the most adherent Candida species, and it has been described as a strong biofilm producer. Environmental factors, phenotypic switching and quorum sensing molecules can affect adhesion and biofilm growth. C. tropicalis can form sexual biofilms, which are promoted by mating pheromones. C. tropicalis biofilms are regulated by a wide and complex network of genes and signaling pathways that are currently poorly understood. Morphological studies showed improved biofilm architecture, which was related to the expression of several hypha-specific genes. Based on recent updates, research is still needed to increase our knowledge on the genetic network of adhesion and biofilm formation by C. tropicalis, as well as the protein diversity that mediates interactions with inert materials and biological surfaces. Here, we have reviewed the main aspects related to adhesion and biofilm formation in C. tropicalis and summarized current knowledge on the significance of these virulence factors in this opportunistic species.

show abstract

Section: Phenotypic Switchingmentioning

confidence: 86%

Section: Phenotypic Switchingmentioning

confidence: 96%

Section: Phenotypic Switchingmentioning

confidence: 96%

Section: Phenotypic Switchingmentioning

confidence: 99%