Effect of phosphatidylcholine in bentonite-quetiapine complex on enhancing drug release and oral bioavailability

Baek, Min-Jun; Kim, Gyu-Ho; Park, Ju-Hwan; Kim, Jaehwan; Kang, Il‐Mo; Kim, Dae‐Duk

doi:10.1016/j.ijpharm.2022.122347

Cited by 4 publications

(4 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The adsorption of orobol and PC onto bentonite was conducted by a previous method with minor modification ( Figure 1 ). 9 , 10 , 19 Various compositions of orobol-loaded bentonite (Bt@Orobol) and orobol-loaded PC-bentonite (Bt-PC@Orobol) composite formulations prepared in this study are summarized in Table 1 . Briefly, to prepare the Bt@Orobol composite formulations, 30 mg of bentonite (Ca 0.15 Na 0.13 K 0.02 )(Ti 0.02 Al 1.28 Fe 0.18 Mg 0.56 )Si 4 O 10 (OH) 2 (Korea Institute of Geoscience and Mineral Resources, Daejeon, Korea), was dispersed into 24.9 mL of 1 N HCl solution.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Combined Orobol-Bentonite Composite Formulation for Effective Topical Skin Targeted Therapy in Mouse Model

Nguyen¹,

Kim²,

Yu³

et al. 2022

IJN

Self Cite

View full text Add to dashboard Cite

Orobol is an isoflavone that has a potent skin protection effect. The objective of this study was to prepare a novel bentonitebased composite formulation of orobol to enhance topical skin delivery. Methods: The composition was optimized based on the orobol content in the composite and the in vitro release studies, followed by the in vitro and in vivo hairless mouse skin deposition studies. Physicochemical characterizations of the composite formulation were performed by powder X-ray refractometry (XRD) and scanning electron microscopy (SEM). The in vitro cytotoxicity and in vivo toxicity studies were conducted in human keratinocytes and in hairless mouse, respectively. Results and Discussions:The in vitro release of orobol from the bentonite composites was higher than that from the suspension, which was further increased with the addition of phosphatidylcholine. The composite formulation significantly enhanced the in vitro and in vivo skin deposition of orobol in hairless mouse skin compared to the orobol suspension. Moreover, the addition of phosphatidyl choline not only improved the dissolution and incomplete release of orobol from the bentonite composite but also enhanced the deposition of orobol in the skin. XRD histograms and SEM images confirmed that the enhanced dissolution of orobol from the composite was attributed to its amorphous state on bentonite. The in vitro and in vivo toxicity studies support the safety and biocompatibility of the orobol-loaded bentonite composite formulation. Conclusion: These findings suggest that the orobol-loaded bentonite composite formulation could be a potential topical skin delivery system for orobol.

show abstract

Section: Methodsmentioning

confidence: 99%

“…Orobol and PC were loaded in the Bt@Orobol and Bt-PC@Orobol formulations based on the adsorption mechanism. 7 , 10 , 19 …”

Section: Methodsmentioning

confidence: 99%

Combined Orobol-Bentonite Composite Formulation for Effective Topical Skin Targeted Therapy in Mouse Model

Nguyen¹,

Kim²,

Yu³

et al. 2022

IJN

Self Cite

View full text Add to dashboard Cite

show abstract

“…74,75,77,78 PC−clays assembly enhanced significantly the oral bioavailability of poorly water-soluble drugs. 79 These clay−lipid hybrids were also studied as efficient nanocarriers for viral particles in influenza vaccine formulations ensuring nondegrading immobilization of viruses. 73 Based on the general biosafety and physicochemical properties of the clay mineral (involving the thermally insulating ceramic material), an interesting feature of these nanoparticle influenza vaccines is their higher thermal stability compared to vaccines with classical adjuvants, which is of great importance for the proper preservation of bioactivity.…”

Section: Hybrid Organic−inorganic Materials From Molecular Intercalat...mentioning

confidence: 99%

“…Physicochemical characterization suggests hydrogen bonding and ion-exchange as the main interaction mechanisms. The resemblance of biological membranes to these clay-based biomimetic systems have been used for entrapment and protection of bioactive species such as enzymes, e.g., cholesterol oxidase and urease, which are useful as an active phase of sensor devices and bioreactors, respectively. ,,, PC–clays assembly enhanced significantly the oral bioavailability of poorly water-soluble drugs . These clay–lipid hybrids were also studied as efficient nanocarriers for viral particles in influenza vaccine formulations ensuring nondegrading immobilization of viruses .…”

Section: Hybrid Organic–inorganic Materials From Molecular Intercalat...mentioning

confidence: 99%

MXenes and Clay Minerals in the Framework of the 2D Organic–Inorganic Hybrid Nanomaterials

Ruiz-Hitzky,

Ruiz-Garcia,

Wang

2023

Chem. Mater.

View full text Add to dashboard Cite

Bentonite as a water-insoluble amorphous solid dispersion matrix for enhancing oral bioavailability of poorly water-soluble drugs

Baek,

Park,

Nguyen

et al. 2023

Journal of Controlled Release

View full text Add to dashboard Cite

Effect of phosphatidylcholine in bentonite-quetiapine complex on enhancing drug release and oral bioavailability

Cited by 4 publications

References 43 publications

Combined Orobol-Bentonite Composite Formulation for Effective Topical Skin Targeted Therapy in Mouse Model

Combined Orobol-Bentonite Composite Formulation for Effective Topical Skin Targeted Therapy in Mouse Model

MXenes and Clay Minerals in the Framework of the 2D Organic–Inorganic Hybrid Nanomaterials

Bentonite as a water-insoluble amorphous solid dispersion matrix for enhancing oral bioavailability of poorly water-soluble drugs

Contact Info

Product

Resources

About