Effect of photobiomodulation on inflammation and production of TGF-ß in experimental model of pulmonary fibrosis

Léia, Auriléia Aparecida De Brito; Herculano, Karine Zanella; Santos, Tawany Gonçalvez; Rigonato‐Oliveira, Nicole Cristine; Alves, Cintia Estefano; Palma, Renata Kelly da; Alvarenga-Nascimento, Cristiano Rodrigo; Ligeiro-Oliveira, Ana Paula

doi:10.1183/13993003.congress-2019.pa5199

Cited by 1 publication

(1 citation statement)

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“…PBM has been shown to be effective in controlling neutrophil activation, thus restoring the balance between pro and antioxidant mediators by reducing pro-inflammatory cytokines (IL-6, TNF-α) and increasing anti-inflammatory cytokines (IL-10) in a mouse model of acute lung injury induced by gut ischemia and reperfusion [ 82 , 90 ]. This has also been shown in mouse models of pulmonary fibrosis [ 91 ] and chronic obstructive airway disease induced by tobacco smoke [ 92 ]. The infiltration of neutrophils into the lungs, which contributes to inflammation, is also reduced by PBM [ 78 ].…”

Section: Pbm In Airway Inflammation Gut Microbiome and Dysautonomiamentioning

confidence: 70%

A Potential Role for Photobiomodulation Therapy in Disease Treatment and Prevention in the Era of COVID-19

Liebert¹,

Bicknell²,

Markman³

et al. 2020

Aging and disease

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COVID-19 is an evolving pandemic that has far reaching global effects, with a combination of factors that makes the virus difficult to contain. The symptoms of infection can be devastating or at the least very debilitating for vulnerable individuals. It is clear that the elderly are at most risk of the adverse impacts of the virus, including hospitalization and death. Others at risk are those with comorbidities such as cardiovascular disease and metabolic conditions and those with a hyper-excitable immune response. Treatment options for those with acute responses to the virus are limited and there is an urgent need for potential strategies that can mitigate these severe effects. One potential avenue for treatment that has not been explored is the microbiome gut/lung axis. In addition to those severely affected by their acute reaction to the virus, there is also a need for treatment options for those that are slow to recover from the effects of the infection and also those who have been adversely affected by the measures put in place to arrest the spread of the virus. One potential treatment option is photobiomodulation (PBM) therapy. PBM has been shown over many years to be a safe, effective, non-invasive and easily deployed adjunctive treatment option for inflammatory conditions, pain, tissue healing and cellular energy. We have also recently demonstrated the effectiveness of PBM to alter the gut microbiome. PBM therapy is worthy of consideration as a potential treatment for those most vulnerable to COVID-19, such as the elderly and those with comorbidities. The treatment may potentially be advantageous for those infected with the virus, those who have a slow recovery from the effects of the virus and those who have been denied their normal exercise/rehabilitation programs due to the isolation restrictions that have been imposed to control the COVID-19 pandemic.

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Section: Pbm In Airway Inflammation Gut Microbiome and Dysautonomiamentioning

confidence: 70%

A Potential Role for Photobiomodulation Therapy in Disease Treatment and Prevention in the Era of COVID-19

Liebert¹,

Bicknell²,

Markman³

et al. 2020

Aging and disease

View full text Add to dashboard Cite

show abstract

Effect of photobiomodulation on inflammation and production of TGF-ß in experimental model of pulmonary fibrosis

Cited by 1 publication

References 0 publications

A Potential Role for Photobiomodulation Therapy in Disease Treatment and Prevention in the Era of COVID-19

A Potential Role for Photobiomodulation Therapy in Disease Treatment and Prevention in the Era of COVID-19

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