Effect of photobiomodulation therapy on inflammatory cytokines in healing dynamics of diabetic wounds: a systematic review of preclinical studies

Karkada, Gagana; Maiya, Arun G.; Houreld, Nicolette Nadene; Arany, Praveen; Rao, K. G. Mohandas; Adiga, Shalini; Kamath, Shobha; Shetty, Somashekar

doi:10.1080/13813455.2020.1861025

Cited by 16 publications

(12 citation statements)

References 39 publications

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“…Nonetheless, TNF-α overexpression can result in chronic and slow-healing acute wounds, as well as host-damaging consequences [13]. Therefore, the remarkable decrease in the level of TNF-α at the second day for all doses could reduce the incidence of infection [14,18,10,31]. In addition, the stimulated increase in IL-1β release emphasised the role of PBM at NIR region in accelerating the healing process.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2023

Int J Bioautomation

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Photobiomodulation (PBM) is a form of the use of visible red and Near-infrared (NIR) light at low power, where a laser light photon is absorbed at the electronic level, without heat production. PBM can be applied in wide range of treatment to help the wound, inflammation, edema, and pain reduction. However, there is a lack of scientific documentation regarding its actual effects. Objectives: This study assesses the impact of PBM on the release of M1-related cytokine in monocyte cells with particular emphasis on interleukin-1β (IL-1β) and Tumour Necrosis Factor α (TNF-α). Methods: Tamm-Horsfall Protein 1 (THP-1) macrophages M1 cells have been exposed to the light from the diode laser of 850 nm at different doses (0, 0.6, 1.2 and 3.6 J/cm 2 ). The release of cytokines was determined by enzymelinked immunosorbent assay, after different periods of incubation (0, 12, 24, and 48 hours) post-irradiation. The proliferation of fibroblast cells suspended in irradiated M1-supernatent was evaluated for the same periods of incubation. Results: The results showed that PBM significantly enhanced M1-related cytokine release (p < 0.05). Obviously, IL-1β increased post-irradiation at 1.2 J/cm 2 more than other doses for all incubation periods. TNF-α was decreased significantly after two days of irradiation (p < 0.005) for all doses. A significant increase in fibroblast proliferation (p < 0.005) was observed concomitant with the boost of cytokine release. Conclusion: This in vitro study has demonstrated that the PBM of the 850 nm diode laser therapy can enhance M1-related cytokine release, which in turn increases the proliferation of fibroblast cells. Moreover, PBM at 850 nm plays an anti-inflammatory role, which manifested by decreasing the level of TNF-α. Therefore, this therapy may be able to accelerate the wound healing process.

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Section: Discussionmentioning

confidence: 99%

Untitled

2023

Int J Bioautomation

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“…They reported that PBM plus G-AgNPs revealed favorable effects to attain increased wound closure and migration in both healthy diabetic wound cell models [39]. Lau et al examined the impact of gold nanoparticles (AuNPs) + PBM (808 nm, 100 mW, 50 s, 5 J/cm2) on the wound restoration process [40]. Lau et al reported that rats exposed to AuNPs plus PBM had significantly higher WCRs [40].…”

Section: Discussionmentioning

confidence: 99%

Application of combined photobiomodulation and curcumin-loaded iron oxide nanoparticles considerably enhanced repair in an infected, delayed-repair wound model in diabetic rats compared to either treatment alone

Omidi

Sohrabi

Amini

et al. 2023

Photochem Photobiol Sci

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Herein, we attempted to evaluate the therapeutic potential of photobiomodulation (PBM) and curcumin-loaded iron nanoparticles (CUR), alone and in combination, on wound closure rate (WCR), microbial flora by measuring colony-forming units (CFUs), the stereological and biomechanical properties of repairing wounds in the maturation stage of the wound healing course in an ischemic infected delayed healing wound model (IIDHWM) of type I diabetic (TIDM) rats. There were four groups: group 1 was the control, group 2 received CUR, rats in group 3 were exposed to PBM (80 Hz, 890 nm, and 0.2 J/ cm 2 ), and rats in group 4 received both PBM and CUR (PBM + CUR). We found CFU was decreased in groups 2, 3, and 4 compared to group 1 (p = 0.000 for all). Groups 2, 3, and 4 showed a considerable escalation in WCR compared to group 1 (p = 0.000 for all). In terms of wound strength parameters, substantial increases in bending stiffness and high-stress load

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“…Previous studies have found a link between the burn's lowest temperature and the final scar depth, but they only take a small portion of the burn into account [1]. Other studies have also established the effectiveness of photobiomodulation in cell regrowth and healing in burn wounds [2]. Studies were carried out on infrared therapy in dermatology and hair restoration, where the light was used to stimulate cell regeneration and hair growth [3].…”

Section: Low-level Light Therapy In Burns Treatmentmentioning

confidence: 99%

“…There was less inflammation and stiffness, which we attributed to infrared therapy. Photobiomodulation has been used to reduce inflammation, improve wound healing (Figure 2, Figure 3), and relieve pain in diabetic patients [2]. The process refers to inducing reactions at the cellular level by exposing the cells to "low-level or near-infrared light" [3].…”

Section: Low-level Light Therapy In Burns Treatmentmentioning

confidence: 99%

The Case Report on the Effectiveness of Infrared Light on Acid Burn Victim

Farhina¹

2022

CRCM

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Burn injuries are common in Pakistan. However, most people are reluctant to have infrared treatment for their wounds. This study investigated the efficacy of infrared treatment on burn wounds. The procedure involved a burn victim who had sustained acid burns to the neck and face. Nectrotomy was done to remove dead tissue from the burn wound, and after treatment, Low-Level Light was used to reduce pain and enhance healing in the patient. Initial results showed mild hypertrophic scars, no stiffness. Post-operation therapy included physical training regimens and massage. The patient showed satisfactory results and felt less tightness in neck movements by the following treatment. The article concludes by showing that infrared light promoted repair and regrowth at a cellular level.

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Effect of photobiomodulation therapy on inflammatory cytokines in healing dynamics of diabetic wounds: a systematic review of preclinical studies

Cited by 16 publications

References 39 publications

Untitled

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Application of combined photobiomodulation and curcumin-loaded iron oxide nanoparticles considerably enhanced repair in an infected, delayed-repair wound model in diabetic rats compared to either treatment alone

The Case Report on the Effectiveness of Infrared Light on Acid Burn Victim

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