Effect of photodynamic therapy adjunct to scaling and root planing in periodontitis patients: A randomized clinical trial

Pulikkotil, Shaju Jacob; Toh, CG; Mohandas, Kavitha; Leong, Kvg

doi:10.1111/adj.12409

Cited by 29 publications

(34 citation statements)

References 50 publications

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“…Torrungruang et al showed that bacterial prevalence and quantity were higher in severe periodontitis subjects compared than in no/mild periodontitis subjects [ 13 ]. Several clinical trials have also evaluated the effectiveness of periodontitis treatment through the quantification of bacteria by qPCR [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Grading system for periodontitis by analyzing levels of periodontal pathogens in saliva

Kim¹,

Joo

Lee³

et al. 2018

PLoS ONE

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Periodontitis is an infectious disease that is associated with microorganisms that colonize the tooth surface. Clinically, periodontal condition stability reflects dynamic equilibrium between bacterial challenge and host response. Therefore, periodontal pathogen assessment can assist in the early detection of periodontitis. Here we developed a grading system called the periodontal pathogen index (PPI) by analyzing the copy numbers of multiple pathogens both in healthy and chronic periodontitis patients. We collected 170 mouthwash samples (64 periodontally healthy controls and 106 chronic periodontitis patients) and analyzed the salivary 16S rRNA levels of nine pathogens using multiplex, quantitative real-time polymerase chain reaction. Except for Aggregatibacter actinomycetemcomitans, copy numbers of all pathogens were significantly higher in chronic periodontitis patients. We classified the samples based on optimal cut-off values with maximum sensitivity and specificity from receiver operating characteristic curve analyses (AUC = 0.91, 95% CI: 0.87–0.96) into four categories of PPI: Healthy (1–40), Moderate (41–60), At Risk (61–80), and Severe (81–100). PPI scores were significantly higher in all chronic periodontitis patients than in the controls (odds ratio: 31.7, 95% CI: 13.41–61.61) and were associated with age, scaling as well as clinical characteristics including clinical attachment level and plaque index. Our PPI grading system can be clinically useful for the early assessment of pathogenic bacterial burden and follow-up monitoring after periodontitis treatment.

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Section: Introductionmentioning

confidence: 99%

Grading system for periodontitis by analyzing levels of periodontal pathogens in saliva

Kim¹,

Joo

Lee³

et al. 2018

PLoS ONE

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“…Aggregatibacter actinomycetemcomitans -0 Fusobacterium nucleatum Although in our study the presence of A. actinomycetemcomitans was inconstant, there are other reports suggesting that conventional SRP alone is inefficient in eliminating aerobe facultative anaerobe species as A. actinomycetemcomitans and it is appropriate to combine other therapies with SRP to remove it from the periodontal pockets. [17][18][19] Based on this observation there is a possibility for the photoactivation of H 2 O 2 with 940 nm diode laser to eliminate aerobe and anaerobe species like A. actinomycetemcomitans and maybe others that could not be investigated in this study. Regarding the keystone periodontal bacteria from the red complex (P. gingivalis, T. denticola, and T. forsythia), all three groups showed high statistical results ( p = 0.000) at 1 month postoperative as given in Table 5.…”

Section: Discussionmentioning

confidence: 98%

Effect of Hydrogen Peroxide Photoactivated Decontamination Using 940 nm Diode Laser in Periodontal Treatment: A Pilot Study

Odor

Bechir

Forna

2020

Photobiomodulation, Photomedicine, and Laser Surgery

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Objective: The aim of this study was to compare the antimicrobial effects of hydroxyl radical generation by photoactivation of hydrogen peroxide (H 2 O 2) with diode laser (k = 940 nm) in combination with conventional nonsurgical periodontal therapy. Materials and methods: Thirty-eight patients and 114 teeth were included in this study. The test teeth were randomly assigned to one of the three treatment groups: Group 1 (control group): scaling and root planning (SRP); and the following experimental groups: Group 2: SRP +940 nm diode laser; Group 3: SRP+photoactivation of H 2 O 2 with 940 nm diode laser. Clinical examinations, such as periodontal probing depth (PPD), clinical attachment level (CAL), and bleeding on probing (BoP) were performed before and after the treatment. The microbiological evaluation included nine periodontal bacterial species investigated by means of real-time polymerase chain reaction assay before and after the treatment. The clinical and bacterial differences were assessed between the investigated groups. Results: The total bacteria load was reduced for all three studied groups and all periodontal indexes (PPD, CAL, and BoP) were improved after each treatment. Group 3 showed significant bacterial reduction of the major periodontal bacteria such as Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Prevotella intermedia, Peptostreptococcus micros, Fusobacterium nucleatum, Eubacterium nodatum (p < 0.001) in contrast to the other two groups (p > 0.001). Differences between tested groups showed significant results with regard to Group 3. Conclusions: The synergistic effect of SRP and photoactivation of H 2 O 2 with 940 nm diode laser offers an efficient and reliable antimicrobial effect in the nonsurgical periodontal treatment approach.

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“…3). Os trabalhos de Moreira et al (2015); Queiroz et al (2015) e Pulikkotil et al (2016) constataram também superioridade do grupo TF, mas diferentemente do presente estudo, obtiveram melhora nos dois grupos.…”

Section: Terapia Fotodinâmicaunclassified

“…Segundo Alwaeli et al (2015), Jervøe-Storm et al (2015), Moreira et al (2015), Queiroz et al (2015), Carrera et al (2016), Pulikkotil et al (2016), Vohra et al (2016) e Belinello-Souza et al (2017), a terapia fotodinâmica (TF) tem sido proposta como adjuvante no tratamento da doença periodontal pelo efeito antimicrobiano, com a vantagem de não causar resistência bacteriana (Jervøe-Storm et al, 2015;Vohra et al, 2016), mas sem estudos publicados desse emprego, em equinos.…”

Section: Introductionunclassified

“…A TF consiste na excitação de um corante, por uma fonte de luz, que, na exposição do oxigênio, gera espécies reativas de oxigênio e oxigênio de singleto, os quais são tóxicos para bactérias e tecido danificado (Alwaeli et al, 2015;Campanile et al, 2015;Jervøe-Storm et al, 2015;Moreira et al, 2015;Queiroz et al, 2015;Carrera et al, 2016;Junqueira et al, 2016;Pulikkotil et al, 2016;Vohra et al, 2016;Belinello-Souza et al, 2017;Ervolino et al, 2019).O objetivo deste trabalho foi estudar o uso da TF na doença periodontal experimental e compará-la à TC, em equinos.…”

Section: Introductionunclassified

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Terapia fotodinâmica como adjuvante no tratamento da doença periodontal em equinos

Dias

Guerreiro

Gandini

et al. 2020

Arq. Bras. Med. Vet. Zootec.

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RESUMO A doença periodontal é uma afecção comum, relacionada ao aprisionamento de alimentos em diastemas não fisiológicos, em equinos. O tratamento consiste na correção da causa primária, limpeza e desbridamento do sulco gengival, denominado tratamento convencional (TC). Frequentemente antimicrobianos são necessários, pela gravidade ou patogenicidade dos agentes. A terapia fotodinâmica adjuvante (TF) tem sido estudada pelo seu potencial combate bacteriano, sem causar resistência bacteriana. O objetivo deste estudo foi analisar o uso da TF na doença periodontal, experimentalmente induzida, em dentes incisivos de equinos, e compará-la com o TC. O TC não resultou em melhora clínica estatisticamente, tanto em graus como em profundidade, apenas numérica na profundidade aos 30 dias. A TF foi empregada em dentes com profundidade maior da bolsa periodontal que a do grupo TC e, mesmo assim, apresentou melhora clínica já com sete dias, e mais efetiva aos 30, atingindo, em média, o valor considerado normal, três milímetros. A TF apresentou potencial para ser aplicada na rotina, pelo incremento nos resultados, sem causar efeitos colaterais.

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Effect of photodynamic therapy adjunct to scaling and root planing in periodontitis patients: A randomized clinical trial

Abstract: Within the limits of the study, PDT adjunct to scaling and root planing does not lead to quantitative reduction of Aa in periodontitis patients.

Cited by 29 publications

References 50 publications

Grading system for periodontitis by analyzing levels of periodontal pathogens in saliva

Grading system for periodontitis by analyzing levels of periodontal pathogens in saliva

Effect of Hydrogen Peroxide Photoactivated Decontamination Using 940 nm Diode Laser in Periodontal Treatment: A Pilot Study

Terapia fotodinâmica como adjuvante no tratamento da doença periodontal em equinos

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