Effect of photodynamic therapy potentiated by ultrasonic chamber on decontamination of acrylic and titanium surfaces

Silva, Douglas Fernandes da; Neto, João Lopes Toledo; Machado, Milena Ferreira; Bochnia, Jetter Ribeiro; Garcez, Aguinaldo Silva; Foggiato, Augusto Alberto

doi:10.1016/j.pdpdt.2019.06.011

Cited by 13 publications

(10 citation statements)

References 51 publications

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“…de sucstoluidina e azul de metileno (MB) estão entre os FS mais estudados para terapia fotodinâmica antimicrobiana (TFDa), que se combinados com luz nos parâmetros apropriados, tornam a dose fotodinâmica citotóxica necessária para inativação microbiana menor do que o necessário para causar danos a células hospedeiras, como queratinócitos e fibroblastos (SOUKOS et al, 1996 As ações do FS podem atingir a célula quando posicionado próximo a uma célula bacteriana sem ligação efetiva, o que pode limitar o dano oxidativo a estruturas externas, como a parede celular, a membrana citoplasmática ou componente intracelular, como proteínas citoplasmáticas ou DNA (CIEPLIK et al, 2018). A TFD também é uma opção no combate a diversas doenças bucais e infecções associadas, tendo uma vantagem sob a antibioticoterapia, que pode ter múltiplos alvos intracelulares, causando infecções oportunistas, reações de hipersensibilidade e resistência microbiana (SILVA et al, 2019) No caso dos fungos, a maioria dos estudos está focada em patógenos fúngicos causados pela maior ocorrência de infecções nosocomiais ou micoses oportunistas em pacientes imunocomprometidos, principalmente no uso de TFD para fungos patogênicos ou potencialmente patogênicos (PERUSSI, 2007). A ação antifúngica da TFD parece ser dependente da voltagem, e o tipo de meio biológico demonstrou afetar a eficácia da TFD in vivo (LIANG et al, 2016).…”

Section: Terapia Fotodinâmica E Controle Microbianounclassified

“…Em adição, a TFD é uma técnica alternativa promissora para descontaminação de materiais, sugerindo seu futuro uso em hospitais (INOMATA et al, 2019), já existindo estudos com dispositivos de Inativação Fotodinâmica, como o dispositivo de Inativação Fotodinâmica (figura 3) Ultrassônica, que propõe a TFD como uma alternativa de baixo custo e atóxica para a desinfecção de dispositivos biomédicos, não críticos e também de uso na indústria de alimentos (SILVA et al, 2019).…”

Section: Terapia Fotodinâmica E Controle Microbianounclassified

“…Figura 2: Inativação fotodinâmica na superfície das placas utilizando Dispositivo de Inativação Fotodinâmica ultrassônica (SILVA et al, 2019).…”

Section: Terapia Fotodinâmica E Controle Microbianounclassified

See 2 more Smart Citations

Educação Em Saúde Sobre Diabetes Mellitus Para Componentes Do Programa De Atenção À Terceira Idade (Proati): Relato De Experiência

Menezes¹,

Silva²,

Silva³

et al. 2021

Novos Paradigmas Voltados Para as Ciências Da Saúde

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Section: Terapia Fotodinâmica E Controle Microbianounclassified

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Educação Em Saúde Sobre Diabetes Mellitus Para Componentes Do Programa De Atenção À Terceira Idade (Proati): Relato De Experiência

Menezes¹,

Silva²,

Silva³

et al. 2021

Novos Paradigmas Voltados Para as Ciências Da Saúde

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“…In the decontamination of products infected by microorganisms and blood, a photodynamic technology is quite advanced, mainly in the sterilization of instruments, is demonstred in the study of Silva et al (SILVA e colab., 2019). This results can be directed to surfaces contaminated by viruses, including against Sars-Cov2.…”

Section: Pdt No Controle Viralmentioning

confidence: 99%

Photodynamic Therapy and Possible Action Against Sars-Cov-2

Queiroz¹,

Foggiato²,

Neto³

et al. 2020

BJD

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Photodynamic therapy is based on the selective photosensitization of a target tissue using a topically or systemically administered agent, which is activated by light, promoting an oxygen-dependent cytotoxic reaction. This study consisted of a literature review that selects articles that show the use of Photodynamic Therapy in health areas, contrsting its use as antimicrobial therapy and the use of action against Sars-Cov-2. In this bibliographic research, the use of photodynamic therapy used in microbial control has demonstrated high effectiveness because it does not cause negative effects or

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“…Since the beginning of the pandemic, new technologies and protocols have been developed with the purpose of exercising microbial control efficiently, thereby targeting a reduction in the infection rate [ 36 , 37 ]. Here, we discuss technologies that have been adopted to help combat contamination by SARS-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

Numerical and experimental analyses for the improvement of surface instant decontamination technology through biocidal agent dispersion: Potential of application during pandemic

et al. 2021

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The transmission of SARS-CoV-2 through contact with contaminated surfaces or objects is an important form of transmissibility. Thus, in this study, we evaluated the performance of a disinfection chamber designed for instantaneous dispersion of the biocidal agent solution, in order to characterize a new device that can be used to protect individuals by reducing the transmissibility of the disease through contaminated surfaces. We proposed the necessary adjustments in the configuration to improve the dispersion on surfaces and the effectiveness of the developed equipment. Computational Fluid Dynamics (CFD) simulations of the present technology with a chamber having six nebulizer nozzles were performed and validated through qualitative and quantitative comparisons, and experimental tests were conducted using the method Water-Sensitive Paper (WSP), with an exposure to the biocidal agent for 10 and 30 s. After evaluation, a new passage procedure for the chamber with six nozzles and a new configuration of the disinfection chamber were proposed. In the chamber with six nozzles, a deficiency was identified in its central region, where the suspended droplet concentration was close to zero. However, with the new passage procedure, there was a significant increase in wettability of the surface. With the proposition of the chamber with 12 nozzles, the suspended droplet concentration in different regions increased, with an average increase of 266%. The experimental results of the new configuration proved that there was an increase in wettability at all times of exposure, and it was more significant for an exposure of 30 s. Additionally, even in different passage procedures, there were no significant differences in the results for an exposure of 10 s, thereby showing the effectiveness of the new configuration or improved spraying and wettability by the biocidal agent, as well as in minimizing the impact caused by human factor in the performance of the disinfection technology.

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Effect of photodynamic therapy potentiated by ultrasonic chamber on decontamination of acrylic and titanium surfaces

Cited by 13 publications

References 51 publications

Educação Em Saúde Sobre Diabetes Mellitus Para Componentes Do Programa De Atenção À Terceira Idade (Proati): Relato De Experiência

Educação Em Saúde Sobre Diabetes Mellitus Para Componentes Do Programa De Atenção À Terceira Idade (Proati): Relato De Experiência

Photodynamic Therapy and Possible Action Against Sars-Cov-2

Numerical and experimental analyses for the improvement of surface instant decontamination technology through biocidal agent dispersion: Potential of application during pandemic

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