Effect of phyllanthus amarus on breeding efficiency of female albino rats

Etta, Hannah Edim; Udoh, Paul; Asuquo, B. O.; Okon, B.

doi:10.4314/gjass.v6i2.2348

Cited by 5 publications

(5 citation statements)

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“…The fruit has green capsules, and smooth and fruiting pedicels while seeds are longitudinally rugose (Obianime and Uche, 2009). It is found throughout the tropics and sub-tropics such as West Africa (including Nigeria and Ghana), Europe, Asia (including China, Pakistan, India and Malaysia indian ocean), central and south America as medicinal plant for the treatment of various diseases (Etta, 2008;Jain et al, 2008). The plant has been used for a long period of time (thousands of years) in Ayurvedic traditional medicine for various illnesses (Adedapo et al, 2005).…”

Section: History Of Phyllanthus Amarusmentioning

confidence: 99%

Medicinal values of the genus Phyllanthus - A review

Unigwe,

Okey

2023

jcbr

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Phyllanthus species are known for their many medicinal values used in folklore medicine in many parts of the world. They have array of phytochemicals in the leaf, flower, seed, stem and root, that confer medicinal advantage on them. Extracts have shown a broad range of pharmacological activities like hepatoprotective, antioxidant, antiviral, antimicrobial, antidiabetic, anti-inflammatory, anticancer, antimalarial, nephroprotective, diuretic, and several other properties. This review highlighted different research results from other scientists in the past and present, all tailored towards exploring the inherent pharmacological properties of this herb for ethno-medicine, alternative medicine and pharmaceutical purposes.

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Section: History Of Phyllanthus Amarusmentioning

confidence: 99%

Medicinal values of the genus Phyllanthus - A review

Unigwe,

Okey

2023

jcbr

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“…It is commonly referred to as Windbreaker or Gale of Wind in English. In Nigeria, it is referred to by various names such as "Ebebenizo" in Bini "Ehin Olobe" in Yoruba, (Etta, 2008), "Ngwu" by the Igbo tribe, "Buchi oro" by the Asaba people and Mache Dagooyo in Hausa. P. amarus is a popular perennial herb that has been used for more than 2000 years in Ayurvedic medicine.…”

Section: Of 15mentioning

confidence: 99%

Computational simulations of phytoconstituents derived from Phyllanthus amarus against Plasmodium falciparum molecular targets

FID,

2023

Drug Dicov

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There has been an increase in the resistance of plasmodium parasites to already available malaria prevention drugs. Hence, the need for novel malaria-preventive medications. This study identified potential antiplasmodial drug candidates from Phyllanthus amarus. The phytoconstituent of Phyllanthus amarus was discovered using the Indian Medicinal Plants, Phytochemistry and Therapeutics Database as well as Dr Duke's phytochemical and ethnobotanical databases. The compounds were screened for ADMET properties and docked with five validated drug targets of Plasmodium falciparum using PyRx software. The molecular dynamics of the best complexes were simulated using Desmond software. A total of 54 compounds were retrieved for Phyllanthus amarus from the databases. Out of the 54 compounds, 26 were druggable, of which the majority showed a good ADMET profile. Amarulone -P. falciparum thioredoxin reductase (4b1b), Amarulone -P. falciparum enoyl-acyl carrier protein Reductase, Amariin-4b1b and Amarulone -Plasmodium falciparum lactate dehydrogenase (1u5c) complexes had the lowest binding energies of -12.3, -11.6, -11.3 and -11.2 kcal/mol, respectively. Amarulone-1u5c complex showed the lowest average RMSD value of 1.86 and 2.02 Å for the heavy backbone and protein-ligand complex, respectively. This makes the complex the most stable complex. Hence, further research should be done on Amarulone as a malaria drug candidate.

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“…Others have also reported that the plant provides antibacterial, antihepatotoxic, and antidiabetic activities (10)(11). This could be associated with the present of different bioactive compounds such as geraniin, gallic acid, rutin and quercetin (10)(11)(12)(13)(14)(15).…”

Section: Phyllanthusmentioning

confidence: 99%

Phyllanthus Sp a Local Plant With Multiple Medicinal Properties

Sd¹,

Yq²,

Sh³

2014

JUMMEC

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The plants of the genus Phyllanthus (Euphorbiaceae) are distributed in most tropical and subtropical regions of world. This plant has been long used as a traditional medicine to treat problems such as stomach, intestinal infections, kidney and urinary bladder disturbances, diabetes, and hepatitis B. There has been considerable interest in these plants in recent years. This review discusses the antiviral and anticancer aspects of Phyllanthus species. Scientific studies have demonstrated that extracts and purified isolated compounds (flavonoids, lignans, phenols, and terpenes) obtained from these plants possess antiviral effects against herpes simplex (HSV) and dengue virus infections (DENV). These observations are associated with the disruption of essential proteins needed during viral cycle, thus halting the viral replication. In addition, the Phyllanthus species have also been shown to exert inhibitory effects against selected cancers types. In these studies anti-proliferative, anti-metastatic, anti-angiogenic effects and induced apoptosis of human cancers cell lines were observed. These may be explained by the disruption of multiple survival pathways and differential protein expression. CONLCUSION:As a conclusion, tThe Phyllanthus plant possesses multiple medicinal properties, including antiviral and anticancer activities which may potentially be used as a medicinal source for many disease locally.

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Effect of phyllanthus amarus on breeding efficiency of female albino rats

Cited by 5 publications

References 0 publications

Medicinal values of the genus Phyllanthus - A review

Medicinal values of the genus Phyllanthus - A review

Computational simulations of phytoconstituents derived from Phyllanthus amarus against Plasmodium falciparum molecular targets

Phyllanthus Sp a Local Plant With Multiple Medicinal Properties

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