Effect of physical fitness on colorectal tumor development in patients with familial adenomatous polyposis

Nakamura, Tomiyo; Ishikawa, Hideki; Sakai, Toshiyuki; Ayabe, Makoto; Wakabayashi, Keiji; Mutoh, Michihiro; Matsuura, Nariaki

doi:10.1097/md.0000000000017076

Cited by 7 publications

(8 citation statements)

References 20 publications

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“…A previous study similarly reported that a high CRF reduced the incidence of colorectal polyps in men by 31.3% [12]. Nakamura et al [21] reported that colorectal polyps exhibited an inverse relationship with CRF. Studies on CRF and polyps are still few compared to cancer studies, and some studies showed that the presence of association differs according to age and sex.…”

Section: Discussionmentioning

confidence: 95%

Prevalence of Colorectal Polyps Based on Cardiorespiratory Fitness, Muscle Strength, Health Behavior, and Abdominal Obesity in Asymptomatic Elderly

Zhang

Kim

et al. 2021

Healthcare

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Colorectal polyps are precursor lesions of colorectal cancer and are known to be associated with obesity, low physical activity, and unhealthy behavior. This cross-sectional study analyzed the prevalence of colorectal polyps based on cardiorespiratory fitness (CRF), muscle strength, and health behavior in older adults. Participants were asymptomatic and included 1024 men and 472 women aged 65–80 years who visited the health care center. Colonoscopy was performed under conscious sedation, and cardiorespiratory fitness was measured as the maximum oxygen uptake using gas analysis. Muscle strength was determined using isokinetic equipment, and physical activity, alcohol consumption, and smoking status were investigated using questionnaires. Waist circumference was measured at the thickest part of the middle of the abdomen. Logistic regression analysis was used to calculate the prevalence of colorectal polyps using odds ratios (ORs) based on the variables. The incidence of colorectal polyps was 65.2% in men and 48.5% in women. The ORs of colorectal polyps for obesity were 1.151 (95% confidence interval [CI], 1.010–2.291) and 1.178 (95% CI, 1.015–2.612) in men and women, respectively. The OR for colorectal polyps in male current smokers was 1.884. The ORs for low CRF were 1.985 and 1.841 in men and women, respectively, compared with high CRF. The prevalence of polyps increased with low muscle strength (men’s OR 1.343 women’s OR 1.440) and physical activity in both men (OR 1.693) and women (OR 1.861). In conclusion, lower CRF and muscle strength were associated with an increased prevalence of colorectal polyps in men and women. In both sexes, high waist circumference and low physical activity increased the prevalence of colorectal polyps.

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Section: Discussionmentioning

confidence: 95%

Prevalence of Colorectal Polyps Based on Cardiorespiratory Fitness, Muscle Strength, Health Behavior, and Abdominal Obesity in Asymptomatic Elderly

Zhang

Kim

et al. 2021

Healthcare

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“…The incidence is relatively higher in populations over 50 years old and relatively lower in those under 50 years old [2]. According to reports from developed countries such as the United States and Australia, due to the popularity of CRC screening in recent years, the incidence of CRC in the United States has declined [3]. The incidence of CRC in males and females has decreased by 2.8% and 2.2% annually on average, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…However, the incidence of CRC in young adults is increasing. The incidence of CRC among young males and females in the 20-49 age group is increased by 1.5% and 1.6%, respectively per year in the United States [3].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: RINT1 is a new suppression target to reduce colon cancer cell growth, migration and invasion through regulating ZW10/NAG-1 expression

Zhao

Huang

et al. 2020

Mol Cell Biochem

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This study explored the function and mechanism of RAD50 interactor 1 (RINT1), Zeste white 10 (ZW10) or nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) in cell growth of colon cancer. The mRNA expression of RINT1 was suppressed in patients with colon cancer. In addition, disease free survival (DFS) in colon cancer patients with high expression of RINT1, ZW10 and NAG-1 were promoted compared with colon cancer patients with low expression of RINT1, ZW10 and NAG-1. Over-expression of RINT1, ZW10 or NAG-1 reduced colon cancer cell growth, migration and invasion in vitro model. In contrast, down-regulation of RINT1, ZW10 or NAG-1 promoted colon cancer cell growth, migration and invasion in vitro model. Over-expression of RINT1 promoted while down-regulation of RINT1 suppressed ZW10 and NAG-1 expression. Following knockdown of ZW10 and NAG-1 protein expressions, RINT1 induced changes of colon cancer cell growth, migration and invasion were inhibited. Taken together, it is indicated that RINT1 is a new suppression target to reduce cell growth, migration and invasion of colon cancer by targeting ZW10/NAG-1.

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“…Besides genetic factors such as family history and inherited syndromes, inflammatory bowel disease may increase the incidence of CRC [ 2 , 3 , 4 ]. In addition, lifestyle factors, such as dietary habits and lack of physical activity, may also contribute to an increased risk of CRC [ 5 , 6 , 7 ]. Although combinations of surgical resection and therapies have been potentially applied to patients depending on the stage and the subtype of cancer, treatment options in this malignancy still remain suboptimal.…”

Section: Introductionmentioning

confidence: 99%

JNK‐mediated Ser27 phosphorylation and stabilization of SIRT1 promote growth and progression of colon cancer through deacetylation‐dependent activation of Snail

et al. 2022

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Sirtuin 1 (SIRT1), an NAD + ‐dependent histone/protein deacetylase, has multifaceted functions in various biological events such as inflammation, aging, and energy metabolism. The role of SIRT1 in carcinogenesis, however, is still under debate. Recent studies have indicated that aberrant overexpression of SIRT1 is correlated with metastasis and poor prognosis in several types of malignancy, including colorectal cancer. In the present study, we found that both SIRT1 and SIRT1 phosphorylated on serine 27 were coordinately upregulated in colon cancer patients’ tissues and human colon cancer cell lines. This prompted us to investigate a role of phospho‐SIRT1 in the context of colon cancer progression. A phosphorylation‐defective mutant form of SIRT1, in which serine 27 was substituted by alanine (SIRT1‐S27A), exhibited lower protein stability compared to that of wild‐type SIRT1. Notably, human colon cancer (HCT‐116) cells harboring the SIRT1‐S27A mutation showed decreased cell proliferation and reduced capability to form xenograft tumor in athymic nude mice, which was accompanied by diminished transcriptional activity of Snail. HCT‐116 cells carrying SIRT1‐S27A were less capable of deacetylating the Snail protein, with a concomitant decrease in the levels of interleukin (IL)‐6 and IL‐8 mRNA transcripts. Taken together, these observations suggest that SIRT1 stabilized through phosphorylation on serine 27 exerts oncogenic effects at least partly through deacetylation‐dependent activation of Snail and subsequent transcription of IL‐6 and IL‐8 in human colon cancer cells.

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Effect of physical fitness on colorectal tumor development in patients with familial adenomatous polyposis

Abstract: Supplemental Digital Content is available in the text

Cited by 7 publications

References 20 publications

Prevalence of Colorectal Polyps Based on Cardiorespiratory Fitness, Muscle Strength, Health Behavior, and Abdominal Obesity in Asymptomatic Elderly

Prevalence of Colorectal Polyps Based on Cardiorespiratory Fitness, Muscle Strength, Health Behavior, and Abdominal Obesity in Asymptomatic Elderly

RETRACTED ARTICLE: RINT1 is a new suppression target to reduce colon cancer cell growth, migration and invasion through regulating ZW10/NAG-1 expression

JNK‐mediated Ser27 phosphorylation and stabilization of SIRT1 promote growth and progression of colon cancer through deacetylation‐dependent activation of Snail

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