Effect of physical training on exercise capacity, gas exchange and N-terminal pro-brain natriuretic peptide levels in patients with chronic heart failure

Sarullo, Filippo M.; Gristina, T.; Brusca, Ignazio; Milia, Salvatore; Raimondi, Raffaella; Sajeva, Massimo; Chiusa, Stella Maria La; Serio, G; Paterna, Salvatore; Pasquale, Pietro Di; Castello, Antonio

doi:10.1097/01.hjr.0000238396.42718.61

Cited by 63 publications

(66 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Berent et al (2009) reported that 4 weeks of moderate exercise reduced the NTproBNP level, independent of the left ventricular ejection fraction, and improved physical Wtness and blood lipid proWles. Physical training of moderate intensity signiWcantly improves exercise capacity and reduces the serum level of NT pro-BNP in patients with chronic heart failure (Maria Sarullo et al 2006). In addition, the blood NT-proBNP level of athletes was signiWcantly lower than that of sedentary controls (Lippi et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Acute effects of walking in forest environments on cardiovascular and metabolic parameters

et al. 2011

View full text Add to dashboard Cite

We previously found that forest environments reduced stress hormones such as adrenaline and noradrenaline and showed the relaxing effect both in male and female subjects. In the present study, we investigated the effects of walking under forest environments on cardiovascular and metabolic parameters. Sixteen healthy male subjects (mean age 57.4 ± 11.6 years) were selected after obtaining informed consent. The subjects took day trips to a forest park in the suburbs of Tokyo and to an urban area of Tokyo as a control in September 2010. On both trips, they walked for 2 h in the morning and afternoon on a Sunday. Blood and urine were sampled on the morning before each trip and after each trip. Blood pressure was measured on the morning (0800) before each trip, at noon (1300), in the afternoon (1600) during each trip, and on the morning (0800) after each trip. The day trip to the forest park significantly reduced blood pressure and urinary noradrenaline and dopamine levels and significantly increased serum adiponectin and dehydroepiandrosterone sulfate (DHEA-S) levels. Walking exercise also reduced the levels of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) and urinary dopamine. Taken together, habitual walking in forest environments may lower blood pressure by reducing sympathetic nerve activity and have beneficial effects on blood adiponectin and DHEA-S levels, and habitual walking exercise may have beneficial effects on blood NT-proBNP levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute effects of walking in forest environments on cardiovascular and metabolic parameters

et al. 2011

View full text Add to dashboard Cite

show abstract

“…CR with ET has been shown to reduce BNP level; 12,13) however, it has remained unclear whether CR reduces ACR in patients with CVD. Supervised exercise training: Total exercise time was significantly longer in the supervised group than in the non-supervised group.…”

Section: Discussionmentioning

confidence: 99%

Impact of Supervised Cardiac Rehabilitation on Urinary Albumin Excretion in Patients With Cardiovascular Disease

et al. 2015

View full text Add to dashboard Cite

SummaryUrinary albumin excretion is a predictor of cardiovascular death. Cardiac rehabilitation (CR) with exercise training (ET) has been shown to improve exercise capacity and prognosis in patients with cardiovascular disease (CVD). However, it remains unclear whether CR reduces urinary albumin excretion in CVD patients. We performed a retrospective, observational study using data obtained from 98 male CVD patients without macroalbuminuria and estimated glomerular filtration rate (eGFR) < 30 mL/minute/1.73 m 2 who participated in CR with ET during hospitalization. Twenty-three patients continued supervised ET for 6 months (supervised group) and 75 patients quit supervised ET (non-supervised group). The supervised ET program consisted of 60 minutes of supervised sessions 1-3 times a week and 30-60 minutes of home exercise at least twice a week. Urinary albumin/creatinine ratio (ACR) was significantly decreased in the supervised group at 6 months after enrollment (43 ± 71 mg/g to 17 ± 20 mg/g creatinine, P < 0.05) but not in the non-supervised group. eGFR was unchanged in the supervised group but was significantly decreased in the non-supervised group (72 ± 18 mL/minute/1.73 m 2 to 67 ± 17 mL/minute/1.73 m 2 , P < 0.001). The results of multiple regression analysis showed that only supervised ET was an independent contributor to ΔACR. CR with supervised ET decreased urinary albumin excretion without deterioration of renal function. These findings suggest that continuation of a supervised ET program is associated with reduction in the development of CVD and reduction in cardiovascular morbidity and mortality in CVD patients. (Int Heart J 2015; 56: 105-109) Key words: Supervised exercise training U rinary albumin excretion has long been recognized as a risk factor for progression to end-stage renal failure in individuals in the general population as well as individuals with hypertension or diabetes mellitus. Recently, urinary albumin excretion has been shown to be associated with an increased incidence of all-cause and cardiovascular morbidity and mortality in general populations and in patients with hypertension or diabetes mellitus. [1][2][3] In addition, low levels of urinary albumin excretion well below the current microalbuminuria threshold have been shown to predict the development of CVD. 4,5) CR with ET has been shown to improve exercise capacity and prognosis in CVD patients.6) Medications such as angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), and statins have also been reported to improve prognosis in CVD patients. In addition, these medications reduce urinary albumin excretion.7-9) However, it remains unclear whether CR ameliorates albuminuria in patients with CVD.The purpose of the present study was to clarify the effect of CR on urinary albumin excretion in patients with CVD.

show abstract

“…This study also demonstrated that early EP could increase physical fitness and could improve QoL within the first month. However, to decrease NT-proBNP level significantly, we probably need a longer period of exercise training, of at least 1.5 months [19].…”

Section: Discussionmentioning

confidence: 99%

“…Exercise training studies that recruited clinically stable, chronic patients with HF were generally considered to be safe, [4] and to decrease the NT-proBNP level, [19] but there was also a study that demonstrated an improvement in fitness level but did change the NTproBNP level, although the exercise training was conducted for 18 weeks [20]. In this study, there was a trend of decreasing the NTproBNP level by EP, but this was not statistically significant, probably due to the short duration of exercise training.…”

Section: Discussionmentioning

confidence: 99%

Early Exercise Program for Patients with Heart Failure after Hospital Discharge

Radi¹,

Santoso²,

Siswanto³

et al. 2017

Int J Phys Med Rehabil

View full text Add to dashboard Cite

show abstract

Effect of physical training on exercise capacity, gas exchange and N-terminal pro-brain natriuretic peptide levels in patients with chronic heart failure

Abstract: Physical training of moderate intensity significantly improves the exercise capacity and neurohormonal modulation in patients with chronic heart failure. This is associated with an alleviation of symptoms and improvement in quality of life.

Cited by 63 publications

References 31 publications

Acute effects of walking in forest environments on cardiovascular and metabolic parameters

Acute effects of walking in forest environments on cardiovascular and metabolic parameters

Impact of Supervised Cardiac Rehabilitation on Urinary Albumin Excretion in Patients With Cardiovascular Disease

Early Exercise Program for Patients with Heart Failure after Hospital Discharge

Contact Info

Product

Resources

About