Effect of physical training on treadmill exercise capacity, collateral circulation and progression of coronary disease

Ferguson, R. James; Petitclerc, Robert; Choquette, G; L, Chaniotis; Gauthier, Pierre; Huot, Roger; Allard, C.; Jankowski, Louis W.; Campeau, Lucien

doi:10.1016/0002-9149(74)90693-6

Cited by 105 publications

(22 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…22 On the other hand, exercise, particularly of aerobic exercise as recommended, does not seem to influence the degree of collateralization, as shown by serial angiographic studies, even in the presence or progression of coronary stenosis. 23,24 However, exercise training appears to be an important component for weight loss and, therefore, should be encouraged in obese patients with coronary heart disease because it produces favourable effects on lipid profile, glucose levels and blood pressure, as well as associated cardiovascular risk. 25,26 Another limitation is that angiographically visible collaterals represent only a fraction of the total collateral vessels as collaterals are angiographically demonstrable only when they reach 100 mm.…”

Section: Discussionmentioning

confidence: 99%

Obesity is associated with impaired coronary collateral vessel development

et al. 2003

View full text Add to dashboard Cite

BACKGROUND: Chronic myocardial ischaemia due to coronary artery stenosis or occlusion has been shown to increase the growth of coronary collateral circulation. Collateralization leads to increased oxygen delivery to the area at risk and hence may reduce ischaemia, prevent infarction and preserve contractile function. However, there is considerable variation among patient subsets in terms of the presence or degree of collateralization. We aimed to evaluate the relationship between obesity and coronary collateral development in patients with ischaemic heart disease. METHODS AND RESULTS:In all, 215 patients (mean age, 57.878.9 y) with body mass index (BMI)Z30 kg/m 2 were enrolled into our study. A total of 90 age-and sex-matched patients (mean age, 58.7710 y) with BMIo25 kg/m 2 and significant coronary artery disease were selected as a control group. The mean age and distribution of risk factors for coronary heart disease were not significantly different between two groups other than poorer HDL cholesterol and triglyceride profile in obese patients. The mean BMI was significantly higher in the patient group (33.372.4 vs 22.871.7, Po0.001). The mean number of diseased vessels and maximum lesion severity were not significantly different between the two groups. The mean Rentrop collateral score of the patient group was significantly worse than the control group (1.0870.68 vs 2.1070.72, Po0.001). CONCLUSIONS: Our findings suggest that collateral vessel development is poorer in obese patients (defined as BMIZ30 kg/m 2 ) with ischemic heart disease compared to normal range BMI, and the risk of having poor collateral vessel development is significantly increased. However, this might be reflecting the cluster of risk factors, associated with metabolic syndrome, in which insulin resistance plays a major role.

show abstract

Section: Discussionmentioning

confidence: 99%

Obesity is associated with impaired coronary collateral vessel development

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Endurance exercise training results in a reduction in myocardial work and oxygen demand, and these changes cause relative reductions in heart rate and blood pressure at rest and during submaximal exercise and also produce an overall general reduction in sympathetic tone.1 Increases in or maintenance of myocardial oxygen supply may result from decreases in the rate of progression of coronary atherosclerosis,10 a decrease in the tendency for platelet aggregation or increased fibrinolytic activity,"1 an increase in the size or dilating capacity of the coronary arteries,12 or an increase in collateral artery formation. 13 None of these effects have been definitely linked to the decreased incidence of coronary artery disease mortality observed in more active or physically fit persons.…”

Section: Author(s)mentioning

confidence: 99%

Physical inactivity. Workshop V. AHA Prevention Conference III. Behavior change and compliance: keys to improving cardiovascular health.

Blair¹,

Powell²,

Bazzarre³

et al. 1993

Circulation

View full text Add to dashboard Cite

“…However, such changes have not yet been found in older, normal subjects. Coronary angiography before and after exercise training has not demonstrated significant changes in atherosclerotic lesions or collateral vessels (52,53). One study analyzed left ventriculograms performed before and after 3 months of cardiac rehabilitation and found no changes (54).…”

Section: Cardiac Morphology and Coronary Atherosclerosismentioning

confidence: 99%

Physical Activity and Coronary Heart Disease

Froelicher

Battler

McKirnan³

1980

Cardiology

View full text Add to dashboard Cite

This review deals with more recent investigations of the health benefit of regular aerobic exercise including studies in: epidemiology, echocardiography, animal research, and cardiac rehabilitation. Recent epidemiological studies support the preventative aspects of exercise in apparently healthy individuals. Echocardiographic studies suggest morphologic changes in young individuals. Recent animal research confirms previous results as well as documenting improvement in cardiac function even under hypoxic and ischemic conditions. Studies of cardiac rehabilitation suggest that medically supervised programs do not improve or worsen morbidity and mortality. The question of whether exercise training can cause cardiac effects in patients with coronary disease rather than just improve the response of the peripheral circulation to exercise may be answered using newer radionuclide techniques.

show abstract

Effect of physical training on treadmill exercise capacity, collateral circulation and progression of coronary disease

Cited by 105 publications

References 18 publications

Obesity is associated with impaired coronary collateral vessel development

Obesity is associated with impaired coronary collateral vessel development

Physical inactivity. Workshop V. AHA Prevention Conference III. Behavior change and compliance: keys to improving cardiovascular health.

Physical Activity and Coronary Heart Disease

Contact Info

Product

Resources

About