Effect of Physiotherapy Intervention after Platelet Rich Plasma Procedure in Subjects with Grade 3 Osteoarthritis Knee

Sowmya, M.V.; Mangayarkarasi, M

doi:10.5958/0974-360x.2020.00371.6

Cited by 6 publications

(1 citation statement)

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“…At the same time, understanding the damage mechanism of articular cartilage tissue is a prerequisite for the treatment of osteoarthritis. According to modern basic medical research, polypeptide growth factors can regulate the synthetic and catabolic processes of cartilage [ 14 ]. Under normal circumstances, the balance between synthesis and decomposition of articular cartilage matrix is maintained by the dynamic balance in quantity between the synthetic and catabolic cytokines in the body.…”

Section: Discussionmentioning

confidence: 99%

Effects of Different Nonsteroidal Anti-Inflammatory Drugs Combined with Platelet-Rich Plasma on Inflammatory Factor Levels in Patients with Osteoarthritis

Jiang

Zhang

Huang³

et al. 2022

Journal of Healthcare Engineering

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Objective. To investigate the effects of different nonsteroidal anti-inflammatory drugs combined with platelet-rich plasma on inflammatory factor levels in patients with osteoarthritis. Methods. The clinic data of 120 patients with osteoarthritis who were treated in our hospital (June 2019-June 2021) were retrospectively reviewed. All the patients were given platelet-rich plasma. According to the different nonsteroidal anti-inflammatory drugs the patients received, they were equalized into diclofenac sodium group, celecoxib group, and iguratimod group, with 40 cases in each group. After treatment, the patients’ clinical efficacy was compared and analyzed. Results. After treatment, the pain degrees of the patients in the three groups were gradually reduced. After 4 weeks and 8 weeks of treatment, the statistical differences in the scores of Visual Analogue Scale (VAS) were found among the three groups. Specifically, compared with the other two groups, the iguratimod group had remarkably lower VAS scores ( P < 0.05 ) and the celecoxib group had signally lower VAS scores compared with the diclofenac sodium group ( P < 0.05 ). After treatment, the inflammatory factor levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) in the diclofenac sodium group were observably higher compared with the celecoxib group ( P < 0.05 ), and the inflammatory factor levels in the celecoxib group were remarkably higher compared with the iguratimod group ( P < 0.05 ). Before treatment, no notable difference in the Lysholm scores was found among the three groups, and the patients’ knee joint function was gradually improved after treatment. To be specific, after 4 and 8 weeks of treatment, the iguratimod group had observably higher Lysholm scores compared with the other two groups ( P < 0.05 ), and the celecoxib group had signally higher Lysholm scores compared with the diclofenac sodium group ( P < 0.05 ). The iguratimod group got markedly lower Western Ontario and McMaster Universities (WOMAC) score compared with the celecoxib group ( P < 0.05 ); Compared with the diclofenac sodium group, the celecoxib group got remarkably lower WOMAC score ( P < 0.05 ). During treatment, few patients suffered from mild gastrointestinal discomfort and hepatic dysfunction in the three groups, and no other severe adverse reactions were found. No statistical difference in the total incidence of adverse reactions among the three groups was observed ( P > 0.05 ). Conclusion. The combination of nonsteroidal anti-inflammatory drugs with platelet-rich plasma can further reduce the inflammatory reactions of the patients with osteoarthritis and improve their knee joint function. Significantly, the iguratimod, with high safety, has observably better effects on inhibiting inflammatory factors and improving knee joint function compared with diclofenac sodium and celecoxib.

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Section: Discussionmentioning

confidence: 99%

Effects of Different Nonsteroidal Anti-Inflammatory Drugs Combined with Platelet-Rich Plasma on Inflammatory Factor Levels in Patients with Osteoarthritis

Jiang

Zhang

Huang³

et al. 2022

Journal of Healthcare Engineering

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The protective effect of both platelet rich plasma and electro-acupuncture on acute pancreatitis caused by tetracycline in rat's model

Zghair

Almaali²,

Hadi³

2022

Revista Internacional de Acupuntura

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The use of Topical Platelet-Rich Plasma on Second Degree Burn Injury: An Experimental study

Paramita

Siregar

et al. 2021

RJPT

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Burn is a tissue injury due to extreme heat, electrical, radiation, corrosive chemical and friction sources. It is one of the major reasons of death and inability and accounts the fourth cause of injuries worldwide. Partial thickness burn damages the epidermis and part of the dermis. Platelet-rich plasma (PRP) has been used in several surgeries and showed a positive result regarding the healing process. In this study, 20 Wistar rats were applied the PRP and 20 others were control Histopathological analysis was done confirming the partial-thickness burn injury. The mean of weight in the control group was 276.2(±14.00) grams compared to 278.7(±11.86) grams in the PRP group, having no statistical difference (p-value 0.609)

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Effect of Physiotherapy Intervention after Platelet Rich Plasma Procedure in Subjects with Grade 3 Osteoarthritis Knee

Cited by 6 publications

References 0 publications

Effects of Different Nonsteroidal Anti-Inflammatory Drugs Combined with Platelet-Rich Plasma on Inflammatory Factor Levels in Patients with Osteoarthritis

Effects of Different Nonsteroidal Anti-Inflammatory Drugs Combined with Platelet-Rich Plasma on Inflammatory Factor Levels in Patients with Osteoarthritis

The protective effect of both platelet rich plasma and electro-acupuncture on acute pancreatitis caused by tetracycline in rat's model

The use of Topical Platelet-Rich Plasma on Second Degree Burn Injury: An Experimental study

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