Effect of phytogenic supplements on the reproductive physiology and metabolic hormones of rabbits exposed to heat stress conditions

Jimoh, Olatunji Abubakar; Daramola, Olajumoke Temidayo; Okin-Aminu, Hafsat Ololade; Ojo, O.A.; Oyeyemi, Wahab Adekunle

doi:10.1016/j.jtherbio.2022.103438

Cited by 6 publications

(6 citation statements)

References 17 publications

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“…It is worth noting that there was overproduction from reactive oxygen species (ROS) under HS conditions, which induced oxidative stress and impaired the function and structure of important molecules such as proteins and nucleic acids [ 52 ]. The production of ROS is balanced by the antioxidant defense system, comprising enzymes such as SOD and GSH.…”

Section: Discussionmentioning

confidence: 99%

“…The affirmative effects of NCEO could be attributed to its antibacterial, antioxidant, and anti-inflammatory properties [ 13 ]. These phytogenic additives can minimize bacteria colonization and hinder the growth of pathogenic and/or non-pathogenic strains of bacteria in the gut of rabbits [ 42 ]; also, they can bring the ecosystems of microbes in the rabbit gut to equilibrium, leading to a better feed efficiency and metabolism [ 52 ]. Studying the pathological alteration of the main organs in the body such as liver and kidney behind the blood chemistry may provide more insights into the potential of using NCEO for improving the functionality of renal/hepato cells in growing rabbits.…”

Section: Discussionmentioning

confidence: 99%

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The Influence of a Nanoemulsion of Cardamom Essential Oil on the Growth Performance, Feed Utilization, Carcass Characteristics, and Health Status of Growing Rabbits under a High Ambient Temperature

Ismail,

Hassan,

Moustafa

et al. 2023

Animals

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Recently, nanotechnology approaches have been employed to enhance the solubility, availability, and efficacy of phytochemicals, overcoming some industrial obstacles and natural biological barriers. In this regard, 120 clinically healthy growing V-line rabbits (5 weeks old) reared during the summer season were divided randomly into four equal experimental groups (30 rabbits each). The first group received a basal diet without the supplementation of the nanoemulsion of cardamom essential oil (NCEO) (0 g/kg diet) and served as a control (NCEO 0). The other groups were given diets containing NCEO at levels of 150 (NCEO 150), 300 (NCEO 300), and 600 (NCEO 600) mg/kg diet, respectively. The growth performance (higher LBW and ADG), feed utilization (lower FCR), dressing percentage, and relative weight of the liver were improved significantly in the NCEO-treated groups compared to the control group. Moreover, the dietary treatment significantly decreased the rectum temperature and respiration rate, minimizing the 350 and 325 mg NECO/kg diets. The erythrocyte count, hematocrit, and hemoglobin concentration were significantly increased (p < 0.05), while white blood cells were significantly diminished (p = 0.0200) in the NCEO300 and NCEO600 groups compared to the control group. Treatment with 300 or 600 mg NCEO/kg significantly increased the blood serum total protein and albumin compared to the control group. Meanwhile, the liver enzymes (AST and ALT), uric acid, and creatinine concentrations decreased significantly in the NCEO300 group compared to the control group. The concentrations of triglycerides and total cholesterol were reduced significantly by the dietary treatment. The total antioxidant capacity, dismutase activity, and glutathione concentration were significantly higher, while the malondialdehyde and protein carbonyl levels were significantly lower in the NCEO300 group than in the control. The inflammatory responses and immunity statuses were improved in the blood serum of the NCEO-treated rabbits compared to the control. Heat-stress-induced pathological perturbations in renal/hepatic tissues and NCEO co-treatment successfully re-established and recovered near-control renal–hepatic morphology. In conclusion, a dietary supplementation of NCEO (300 mg/kg) could effectively enhance growing rabbits’ growth indices, feed efficiency, redox balance, immunity, and inflammatory responses during the summer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Influence of a Nanoemulsion of Cardamom Essential Oil on the Growth Performance, Feed Utilization, Carcass Characteristics, and Health Status of Growing Rabbits under a High Ambient Temperature

Ismail,

Hassan,

Moustafa

et al. 2023

Animals

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“…To assess the impact of heat stress on mammalian reproductive cells, we primarily focused on articles published In response to these challenges, numerous researchers have advocated for exogenous supplementation with antioxidants to mitigate the elevated levels of reactive oxygen species (ROS) induced by HS and enhance the antioxidant capacity of mammalian reproductive cells [30,31,47,[73][74][75][76]. Consistently, positive outcomes have been observed for supplementation with antioxidants, whether in the form of herbal medicines or feed additives, in improving the efficiency of mammalian reproductive cells such as granulosa cells, Leydig cells, and Sertoli cells by alleviating oxidative stress [77][78][79][80][81][82][83][84][85]. The beneficial impact of antioxidant supplementation in mitigating the adverse effects of heat stress on phenotypic traits related to mammalian reproduction has been succinctly illustrated in Figure 1.…”

Section: Literature Search and Selection Criteriamentioning

confidence: 99%

Advancements in Genetic Biomarkers and Exogenous Antioxidant Supplementation for Safeguarding Mammalian Cells against Heat-Induced Oxidative Stress and Apoptosis

Khan,

Chen

et al. 2024

Antioxidants

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Heat stress represents a pervasive global concern with far-reaching implications for the reproductive efficiency of both animal and human populations. An extensive body of published research on heat stress effects utilizes controlled experimental environments to expose cells and tissues to heat stress and its disruptive influence on the physiological aspects of reproductive phenotypic traits, encompassing parameters such as sperm quality, sperm motility, viability, and overall competence. Beyond these immediate effects, heat stress has been linked to embryo losses, compromised oocyte development, and even infertility across diverse species. One of the primary mechanisms underlying these adverse reproductive outcomes is the elevation of reactive oxygen species (ROS) levels precipitating oxidative stress and apoptosis within mammalian reproductive cells. Oxidative stress and apoptosis are recognized as pivotal biological factors through which heat stress exerts its disruptive impact on both male and female reproductive cells. In a concerted effort to mitigate the detrimental consequences of heat stress, supplementation with antioxidants, both in natural and synthetic forms, has been explored as a potential intervention strategy. Furthermore, reproductive cells possess inherent self-protective mechanisms that come into play during episodes of heat stress, aiding in their survival. This comprehensive review delves into the multifaceted effects of heat stress on reproductive phenotypic traits and elucidates the intricate molecular mechanisms underpinning oxidative stress and apoptosis in reproductive cells, which compromise their normal function. Additionally, we provide a succinct overview of potential antioxidant interventions and highlight the genetic biomarkers within reproductive cells that possess self-protective capabilities, collectively offering promising avenues for ameliorating the negative impact of heat stress by restraining apoptosis and oxidative stress.

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“…Higher concentrations of corticosteroids in birds, particularly during heat stress, enhance catabolic effects along with increased oxidative stress, resulting in muscle loss and decreased growth (Beckford et al 2020). The elevated leptin levels during chronic heat stress signal satiety or prevent food intake (Jimoh et al 2023). Additionally, as revealed in our study, heat stress reduces the concentration of T3, which controls metabolic rate in broiler chickens.…”

Section: Disccusionmentioning

confidence: 99%

Probiotic Strategies for Mitigating Heat Stress Effects on Broiler Chicken Performance

Aydin,

Hatipoglu

2024

Preprint

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The primary objective of this study was to evaluate the effects of liquid (F-LAB) and commercial (C-LAB) probiotics sourced from Rye-Grass Lactic Acid Bacteria on broiler chickens experiencing heat stress (HS). The research involved 240 broiler chicks divided into six groups: control, F-LAB, C-LAB (raised at 24°C), HS, F-LAB/HS, and C-LAB/HS (exposed to 5–7 hours of 34–36°C daily). While F-LAB and HS/F-LAB groups received a natural probiotic added to their drinking water at a rate of 0.5 ml/L, C-LAB and HS/C-LAB groups were supplemented with a commercial probiotic at the same dosage. No probiotic supplementation was administered to the control and HS groups. The results revealed that without probiotic supplementation, heat stress led to a decrease in body weight gain, T3 levels, citrulline, and growth hormone levels, along with an increase in the feed conversion ratio, serum corticosterone, HSP70, ALT, AST, and leptin levels. Heat stress also adversely affected cecal microbiota, reducing lactic acid bacteria (LABC) while increasing Escherichia coli and coliform bacteria (CBC) counts. However, in the groups receiving probiotic supplementation under heat stress (F-LAB/HS and C-LAB/HS), these effects were alleviated. Particularly noteworthy was the observation that broiler chickens supplemented with natural lactic acid bacteria (F-LAB) exhibited greater resilience to heat stress compared to those receiving the commercial probiotic, as evidenced by improvements in growth, liver function, hormonal balance, intestinal health, and cecal microbiome ecology. These findings suggest that the supplementation of naturally sourced probiotics (F-LAB) may positively impact the intestinal health of broiler chickens exposed to heat stress, potentially supporting growth and health parameters.

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Effect of phytogenic supplements on the reproductive physiology and metabolic hormones of rabbits exposed to heat stress conditions

Cited by 6 publications

References 17 publications

The Influence of a Nanoemulsion of Cardamom Essential Oil on the Growth Performance, Feed Utilization, Carcass Characteristics, and Health Status of Growing Rabbits under a High Ambient Temperature

The Influence of a Nanoemulsion of Cardamom Essential Oil on the Growth Performance, Feed Utilization, Carcass Characteristics, and Health Status of Growing Rabbits under a High Ambient Temperature

Advancements in Genetic Biomarkers and Exogenous Antioxidant Supplementation for Safeguarding Mammalian Cells against Heat-Induced Oxidative Stress and Apoptosis

Probiotic Strategies for Mitigating Heat Stress Effects on Broiler Chicken Performance

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