The present paper provides a brief overview of the existing methods for energy separation and an analysis of the possibility of the practical application of the Hartmann–Sprenger effect to provide quasi-isothermal pressure reduction of natural gas at the facilities within a gas transmission system. The recommendations of external authors are analyzed. A variant of a quasi-isothermal pressure regulator is proposed, which assumes the mixing of flows after energy separation. Using a numerical simulation of gas dynamics, it is demonstrated that the position of the resonators can be determined on the basis of calculations of the structure of the underexpanded jet without taking into account the resonator and, accordingly, without the need for time-consuming calculations of the dynamics of the processes. Based on the results of simulating the gas dynamics of two nozzle–resonator pairs installed in a single flow housing, it is shown that, in order to optimize the regulator length, the width of the passage between the two nearest resonators should be greater than or equal to the sum of diameters of the critical sections of the nozzles. Numerical vibroacoustic analysis demonstrated that the most dangerous part of the resonator is the frequency of its natural oscillations.