Effect of Piper betel leaf stalk extract on protein metabolism in reproductive tissues of male albino rats

Vengaiah, V.; Govardhan, A.; Changamma, C.

doi:10.1016/s2305-0500(15)30002-6

Cited by 1 publication

(1 citation statement)

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“…Interestingly, the decrease in body and reproductive organs masses, total protein levels, fertility parameters and serum and testicular testosterone levels as well as the testicular and epididymal impairments observed in untreated diabetic rats were significantly alleviated after 4 weeks of treatment with D. arborea extracts, especially the aqueous extract (500 mg/kg). This increase in total proteins level which is fundamentally related to the increase in the body and reproductive organs masses might be due to the presence of bioactive components in D. arborea extracts capable to improve proteins anabolism and prevent oxidative stress (Nair et al, ; Vengaiah, Govardhan, & Changamma, ). Although slight increase was observed after treatment in testicular SOD activity, CAT activity was significantly elevated in rats testes treated with TMAO (Lupachyk et al, ) and D. arborea extracts.…”

Section: Discussionmentioning

confidence: 99%

Aqueous and ethanol extracts ofDracaena arborea(Wild) Link (Dracaenaceae) alleviate reproductive complications of diabetes mellitus in rats

et al. 2019

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Reproductive dysfunction is one of the most prevalent diabetes complications. Draceana arborea is known to enhance sexual function in diabetic rats, but the underlying mechanisms have not been thoroughly elucidated. This study examined the effects of D. arborea on some reproductive complications of diabetes in rats. Aqueous and ethanol (500 and 100 mg/kg respectively) extracts of D. arborea, Sildenafil citrate (1.44 mg/kg), trimethylamine‐N‐oxide (TMAO, 20 mg/kg) and distilled water (10 ml/kg) were orally administered for 28 days to streptozotocin‐induced diabetic rats. Glycaemia, body and reproductive organ masses, fertility parameters, total proteins, antioxidant enzymes activities, serum and testicular testosterone and the histology of the testes and epididymis were determined. Results revealed significant decreases in body and absolute and relative masses of testes, epididymis, seminal vesicles, prostate and vas deferens, fertility parameters, epididymal and testicular total proteins, serum and testicular testosterone levels as well as antioxidant enzymes activities. Interestingly, while having minor anti‐hyperglycaemic effects, these abnormalities associated with testicular and epididymal alterations were alleviated by D. arborea especially the aqueous extract (500 mg/kg). These outcomes provided evidence of the androgenic properties of D. arborea in diabetic rats, which could be useful for a better management of sexual dysfunctions in diabetic patients.

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Section: Discussionmentioning

confidence: 99%