Effect of Piper cubeba L. fruit on ethylene glycol and ammonium chloride induced urolithiasis in male Sprague Dawley rats

Bano, Humaira; Jahan, Nasreen; Makbul, Shaikh Ajij Ahmed; Kumar, B.N.; Husain, Sadique; Sayed, A El

doi:10.1016/j.imr.2018.06.005

Cited by 16 publications

(18 citation statements)

References 21 publications

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“…The results shown in Table (2) showed a significant decrease in the concentration of Mg ion in the group treated with E.g with a concentration of (0.9%) compared with the healthy control group, The results of our current study are consistent with what (Ibrahim,2012) brought. Where it indicated a significant decrease in the concentration of Mg in rats treated with Eg with a concentration (1%), and our study agrees with they (Bano et al, 2018) the ethylene glycol has a toxic effect on the digestive system, leading to a defect in the absorption process of magnesium and the process of its excretion outside the body Consequently, its concentration will decrease and this corresponds to the results of our study.…”

Section: Resultssupporting

confidence: 92%

The Protective Role of Aqueous Extract of Plant Roots Cichorium Intybus L. In a Number of Biochemical Variables in the Blood Serum and Tissues of Rabbits Infected With Experimental Kidney Stones

Hassan¹,

Ahmed²

2021

PLANT ARCHIVES

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This study aimed to know the protective role of Cichorium intybus root aqueous extract in inhibiting the formation of kidney stones induced by ethylene glycol in male Oryctolagus cumiculus, expressed by monitoring kidney function and studying the effect of oxidative stress induced by ethylene glycol, as well as by microscopic examination of kidney tissue. In this study, male domestic rabbits used Oryctolag cuniculus with (20) animals whose ages ranged from (6-8) months and were examined by a veterinarian and their weights ranged between (1500 + 100) gm. The animals were divided into four experimental groups by 5 rabbits / Group, dosed for 60 days, as follows: The first group was given water and food throughout the trial period, The second group dosed (50 mg / kg of body weight) with Cichorium intybus root aqueous extract, while the third group was dosed with ethylene glycol at a concentration of (0.9%) mL / kg of body weight, and the fourth group was dosed with ethylene glycol in addition to Cichorium intybus root aqueous extract. The results showed that the formation of stones induced by ethylene glycol in male white rabbits led to negative effects in the biochemical variables, represented by a significant increase at a probability level (P≤ 0.05) in in total protein, urea, creatinine and K ion, and treatment with this substance did not lead to a change in albumin. And Mg ion and Ca ion, while the treatment with E.g led to a decrease in the occurrence of histological changes and calcium crystal deposition were evident in the kidneys. The results of the group treated with Cichorium intybus root aqueous extract at a concentration (50 mg / kg of body weight) showed a significant increase, Mg, and did not affect, albumin, and a decrease in creatine, total protein, and urea. Ca compared with the control group, while no tissue changes occurred to the kidneys. The treatment with Cichorium intybus root aqueous extract and the treatment with ethylene glycol at a concentration of (0.9%) led to a decrease in Ca, K, creatinine, total protein, urea, albumin and a significant increase in, Mg, to a group Control treated with ethylene glycol, and this treatment led to a significant improvement in kidney tissue.

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Section: Resultssupporting

confidence: 92%

The Protective Role of Aqueous Extract of Plant Roots Cichorium Intybus L. In a Number of Biochemical Variables in the Blood Serum and Tissues of Rabbits Infected With Experimental Kidney Stones

Hassan¹,

Ahmed²

2021

PLANT ARCHIVES

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“…The crude extract was obtained by filtration through filter paper. The filtrate was evaporated by rotatory evaporator to give a viscous brownish dark mass and the extract was preserved in a refrigerator at 2°C-8°C for use in the experiments (Bashir and Gilani, 2009). The yield value of the extract was 6% (w/w).…”

Section: Plant Materials and Extractionmentioning

confidence: 99%

“…The overall recurrence rate is high in male (70%-80%) as compared with female (47%-60%) (Ahmed et al, 2018;Wang et al, 2019). Approximately, 80% of stones are calcium-containing stones which are found as pure calcium oxalate (CaOx) (50%), pure calcium phosphate (1%), or a mixture of both (45%), and other stones are struvite (10%), uric acid (9%), and cystine (1%) (Bashir and Gilani, 2009;Namburu et al, 2017). CaOx (CaC 2 O 4 ) stones are found as CaOx monohydrate or CaOx dehydrate form.…”

Section: Introductionmentioning

confidence: 99%

“…Caesalpinia bonducella Roxb. (Caesalpiniaceae) is extensively used in the traditional medicine (Bawari et al, 2020;Bashir and Gilani, 2009;Datte et al, 1998;Iheagwam et al, 2019;Liu et al, 2020). The various parts of C. bonducella have been reported for anti-cancer and cytotoxic activities (Iheagwam et al, 2019); contractile activity of uterine smooth muscle (Datte et al, 1998); inhibit nuclear factor-kappa B and type-4 phosphodiesterase (Liu et al, 2020); antimicrobial activities (Arif et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Toxicity (acute and subacute) assessment and in-vivo antiurolithiatic activity of ethanolic extract of Caesalpinia bonducella seed in albino Wistar rat

Kumar¹,

Kumar²,

Brijesh³

et al. 2022

J App Pharm Sci

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The objective of the present work is to find supportive evidence for the use of Caesalpinia bonducella in nephrolithiasis. For safety assessment of ethanolic extract of seed of C. bonducella (ECB), acute and subacute oral toxicity studies was performed. In the acute oral toxicity study at a dose of 2,000 mg/kg and subacute oral toxicity study at dose of 250, 500, and 1,000 mg/kg, no changes were seen in the behavior, haematological parameters, biochemical parameters, histopathology of major organ, and body weight of rats. The efficacy of ECB at dose of 200 and 400 mg/kg was studied in ethylene glycol, glycolic acid, and sodium oxalate induced urolithiasis in rats and marketed cystone tablet at a dose of 750 mg/kg was used as the standard drug. The mean body weight difference, urinary parameters (urine pH, urine volume, levels of calcium, magnesium, and phosphorus), and serum biochemical parameters [urea, Blood urea nitrogen (BUN), creatinine, uric acid, and alkaline phosphatase] were measured. Urolithiasis caused a significant decrease in mean body weight, pH, and volume of urine and increased in both serum biochemical parameters and urinary electrolyte concentration as compared with the normal control group. Histopathology of kidneys were showed increased glomerular hypercellularity, hydropic tubular degeneration, and cast in the induced control group. Ethanolic Extract of Caesalpinia bonducella (ECB) was found to be effective to normalise the above all changes. It was concluded that the ECB was effective in the prevention and elimination of calcium oxalate crystal deposition into kidneys.

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“…Ethylene glycol (EG) induced urolithiasis method was used to assess anti-urolithiatic activity in rats. 7 36 albino wistar rats of either sex weighing 150-180 gm were divided into 6 groups. Group I: Vehicle Control group (VC) was administered with CMC (1% w/v) and distilled water (2 ml/kg), p.o for 28 days.…”

Section: Experimental Designmentioning

confidence: 99%

Evaluation of Anti-urolithiatic Potential of Leaves of Alstonia scholaris and its Isolated Pentacyclic Triterpenoids in Ethylene Glycol-induced Renal Calculi Rat Model

S¹,

Sanaye²

2021

IJPER

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Introduction: Urolithiasis has afflicted human race since the days of yore. Conventional treatment acts only on associated ailments whereas pharmacologically active phytoconstituents derived from plants are reported to possess lithotriptic as well as anti-urolithiatic effect, thus herbal sources need to be scientifically explored. Present study was aimed to evaluate anti-urolithiatic potential of leaves of Alstonia scholaris and its isolated pentacyclic triterpenoids: lupeol and ursolic acid in ethylene glycolinduced renal calculi rat model. Materials and Methods: Leaves of Alstonia scholaris were extracted with various solvents, amount of triterpenoids in each extract was quantified using HPTLC. Extract which had higher amount of triterpenoid was evaluated for its anti-urolithiatic effect. Albino wistar rats of either sex were divided into 6 groups. All groups except vehicle were fed with 0.75%v/v of ethylene glycol for 28 days. Treatment with standard cystone, low and high dose of extract and pentacyclic triterpenoids were given to respective groups from 4 th-28 th day of study. On 28 th day, serum creatinine, uric acid, BUN, TNF-α, IL-6 and urinary electrolyte levels were estimated. Kidneys were isolated, one was used for histopathological study and other for antioxidant assays. Results and Discussion: Histopathological examination of kidneys revealed destructed morphology due to deposition of large polymorphic crystals and cystic dilatation of tubules. Whereas treatment with extract and its pentacyclic triterpenoids prevented renal damage and deposition of crystals. Perturbations in levels of nitrogenous wastes, inflammatory mediators and urinary electrolytes were also prevented. Alstonia scholaris rich in triterpenoid significantly arrested associated oxidative stress and inflammation thus preventing formation of renal calculi. Conclusion: Leaves of Alstonia scholaris and pentacyclic triterpenoids isolated from them demonstrates potent herbal remedy for treatment of urolithiasis.

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Effect of Piper cubeba L. fruit on ethylene glycol and ammonium chloride induced urolithiasis in male Sprague Dawley rats

Abstract: Graphical abstract

Cited by 16 publications

References 21 publications

The Protective Role of Aqueous Extract of Plant Roots Cichorium Intybus L. In a Number of Biochemical Variables in the Blood Serum and Tissues of Rabbits Infected With Experimental Kidney Stones

The Protective Role of Aqueous Extract of Plant Roots Cichorium Intybus L. In a Number of Biochemical Variables in the Blood Serum and Tissues of Rabbits Infected With Experimental Kidney Stones

Toxicity (acute and subacute) assessment and in-vivo antiurolithiatic activity of ethanolic extract of Caesalpinia bonducella seed in albino Wistar rat

Evaluation of Anti-urolithiatic Potential of Leaves of Alstonia scholaris and its Isolated Pentacyclic Triterpenoids in Ethylene Glycol-induced Renal Calculi Rat Model

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