Effect of pistachio diet on lipid parameters, endothelial function, inflammation, and oxidative status: A prospective study

Sarı, İbrahim; Baltaci, Yasemin; Bağcı, Cahit; Davutoğlu, Vedat; Erel, Özcan; Çelik, Hakim; Özer, Orhan; Aksoy, Nur; Aksoy, Mehmet

doi:10.1016/j.nut.2009.05.023

Cited by 147 publications

(211 citation statements)

References 18 publications

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“…Since only flavonol monomers and dimeric proanthocyanidins are absorbed [58][59][60][61], systemic effects of proanthocyanidins would be limited to these compounds or eventually to not yet characterized metabolites and/or colonic degradation products from the polymeric molecules [58]. In this context, our findings cannot help to rationalize the cardiovascular protection nor provide a molecular interpretation for the anti-inflammatory effects of pistachio nut diets [20]. Eventual beneficial effects of polymeric proanthocyanidins could be considered at the gastrointestinal level [58,62].…”

Section: Conclusive Remarksmentioning

confidence: 93%

“…Potential mechanisms of the cardiovascular protective action have been suggested, including effects on plasma stearoyl-CoA desaturase activity [19]. More recent studies in healthy subjects showing that a pistachio diet for 4 weeks significantly improves endothelial function and oxidative status and is associated with lower levels of circulating inflammatory biomarkers [20] may suggest that anti-inflammatory activities of nut components play a role in preventing pathogenetic events leading to CVD. Systemic markers of inflammation have been demonstrated strong predictors of cardiovascular disease [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Polymeric proanthocyanidins from Sicilian pistachio (Pistacia vera L.) nut extract inhibit lipopolysaccharide-induced inflammatory response in RAW 264.7 cells

et al. 2011

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Background Positive effects of pistachio nut consumption on plasma inflammatory biomarkers have been described; however, little is known about molecular events associated with these effects. Purpose We studied the anti-inflammatory activity of a hydrophilic extract from Sicilian Pistacia L. (HPE) in a macrophage model and investigated bioactive components relevant to the observed effects. Methods HPE oligomer/polymer proanthocyanidin fractions were isolated by adsorbance chromatography, and components quantified as anthocyanidins after acidic hydrolysis. Isoflavones were measured by gradient elution HPLC analysis. RAW 264.7 murine macrophages were pre-incubated with either HPE (1-to 20-mg fresh nut equivalents) or its isolated components for 1 h, then washed before stimulating with lipopolysaccharide (LPS) for 24 h. Cell viability and parameters associated with Nuclear Factor-jB (NF-jB) activation were assayed according to established methods including ELISA, Western blot, or cytofluorimetric analysis. Results HPE suppressed nitric oxide (NO) and tumor necrosis factor-a (TNF-a) production and inducible NO-synthase levels dose dependently, whereas inhibited prostaglandin E 2 (PGE 2 ) release and decreased cyclooxygenase-2 content, the lower the HPE amount the higher the effect. Cytotoxic effects were not observed. HPE also caused a dose-dependent decrease in intracellular reactive oxygen species and interfered with the NF-jB activation.Polymeric proanthocyanidins, but not isoflavones, at a concentration comparable with their content in HPE, inhibited NO, PGE 2 , and TNF-a formation, as well as activation of IjB-a. Oligomeric proanthocyanidins showed only minor effects. Conclusions Our results provide molecular evidence of anti-inflammatory activity of pistachio nut and indicate polymeric proanthocyanidins as the bioactive components. The mechanism may involve the redox-sensitive transcription factor NF-jB. Potential effects associated with pistachio nut consumption are discussed in terms of the proanthocyanidin bioavailability.

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Section: Conclusive Remarksmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Polymeric proanthocyanidins from Sicilian pistachio (Pistacia vera L.) nut extract inhibit lipopolysaccharide-induced inflammatory response in RAW 264.7 cells

et al. 2011

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“…Two further studies have assessed the effects of nuts on vascular reactivity [107,126]. A recent study from Turkey reported improved FMD after a diet supplemented with pistachios compared with a healthy diet, but the sequential design of the interventions precludes firm conclusions [126].…”

Section: Nut Feeding Trials With Outcomes On Cardiovascular Risk Fmentioning

confidence: 99%

“…A recent study from Turkey reported improved FMD after a diet supplemented with pistachios compared with a healthy diet, but the sequential design of the interventions precludes firm conclusions [126]. Finally, a 12-week parallel design study in patients with metabolic syndrome comparing healthy diets with or without supplementation with 30 g of mixed nuts per day found no between-diet differences in vascular reactivity, as assessed by digital pulse amplitude tonometry [107].…”

Section: Nut Feeding Trials With Outcomes On Cardiovascular Risk Fmentioning

confidence: 99%

Health Benefits of Nut Consumption

2010

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Nuts (tree nuts and peanuts) are nutrient dense foods with complex matrices rich in unsaturated fatty and other bioactive compounds: high-quality vegetable protein, fiber, minerals, tocopherols, phytosterols, and phenolic compounds. By virtue of their unique composition, nuts are likely to beneficially impact health outcomes. Epidemiologic studies have associated nut consumption with a reduced incidence of coronary heart disease and gallstones in both genders and diabetes in women. Limited evidence also suggests beneficial effects on hypertension, cancer, and inflammation. Interventional studies consistently show that nut intake has a cholesterol-lowering effect, even in the context of healthy diets, and there is emerging evidence of beneficial effects on oxidative stress, inflammation, and vascular reactivity. Blood pressure, visceral adiposity and the metabolic syndrome also appear to be positively influenced by nut consumption. Thus it is clear that nuts have a beneficial impact on many cardiovascular risk factors. Contrary to expectations, epidemiologic studies and clinical trials suggest that regular nut consumption is unlikely to contribute to obesity and may even help in weight loss. Safety concerns are limited to the infrequent occurrence of nut allergy in children. In conclusion, nuts are nutrient rich foods with wide-ranging cardiovascular and metabolic benefits, which can be readily incorporated into healthy diets.

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“…The majority of studies investigating the effects of regular nut consumption on inflammatory markers have reported no significant differences between nut-enriched diets and baseline or a comparison diet [37][38][39][40][41][42][43][44][45]. One previous study over 8-weeks reported a statistically significant increase in hs-CRP from baseline to the end of study with the addition of walnuts, however this increase did not differ significantly to those consuming cashew nuts or no nuts (control) [46].…”

Section: Discussionmentioning

confidence: 99%

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2015

Journal of Nutrients

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Aims Studies reporting reductions in heart disease risk with regular nut consumption comprise populations largely of European descent. Whether the healthful effects of nuts extend to other ethnic groups is Contribution/ OriginalityThis study is one of very few studies, which have investigated the effects of nuts on different ethnic groups. Our results suggest that the health benefits and acceptability of nuts seen in predominantly Caucasian populations can be extended to Māori, the indigenous population within New Zealand.

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Effect of pistachio diet on lipid parameters, endothelial function, inflammation, and oxidative status: A prospective study

Cited by 147 publications

References 18 publications

Polymeric proanthocyanidins from Sicilian pistachio (Pistacia vera L.) nut extract inhibit lipopolysaccharide-induced inflammatory response in RAW 264.7 cells

Polymeric proanthocyanidins from Sicilian pistachio (Pistacia vera L.) nut extract inhibit lipopolysaccharide-induced inflammatory response in RAW 264.7 cells

Health Benefits of Nut Consumption

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