Effect of Pistachio Nuts on Serum Lipid Levels in Patients with Moderate Hypercholesterolemia

Edwards, K D; Kwaw, Isidore; Matud, Jose L.; Kurtz, Ira

doi:10.1080/07315724.1999.10718856

Cited by 129 publications

(136 citation statements)

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“…Incorporation of hazelnut (40 g/day) into human diet favorably altered multiple plasma lipid variables in hypercholesterolemic adult men (Figure 1 and Table 5). Our results are comparable to those reported for other tree nuts such as almond (Hyson et al, 2002), macadamia (Garg et al, 2003), pecan (Rajaram et al, 2001), pistachio (Edwards et al, 1999) and walnut (Zambó n et al, 2000), despite the fact that inclusion of Effects of hazelnut-enriched diet on plasma lipid profiles SM Mercanlıgil et al hazelnut into the human diet in our study was less than half of those reported for other nuts. The intake of SFA generally increases the risk of CHD by increasing the concentrations of total and LDL cholesterol, and Apo B, and increasing the ratios of total/HDL cholesterol and LDL/HDL cholesterol (NRC, 1989).…”

Section: Effects Of Hazelnut-enriched Diet On Plasma Lipid Profiles Ssupporting

confidence: 85%

“…Hazelnut-enriched diet compared with baseline favorably altered (Po0.05) these important parameters in cardioprotective direction. Edwards et al (1999) reported that substituting 20% of the daily caloric intake in the form of pistachio nuts after 3-week period significantly reduced both total/HDL cholesterol and LDL/HDL cholesterol ratios in subjects with moderate hypercholesterolemia compared to initial values.…”

Section: Effects Of Hazelnut-enriched Diet On Plasma Lipid Profiles Smentioning

confidence: 98%

“…In contrast, there was no difference between the control diet and the baseline. The significant increase in HDL cholesterol concentrations has been reported after consumption of tree nuts such as hazelnut (Durak et al, 1999), almond (Hyson et al, 2002), pistachio (Edwards et al, 1999) and macadamia (Garg et al, 2003). It can be speculated that the increase in HDL cholesterol might be most likely due to decreased triglycerides, where HDL becomes less of a substrate for catabolism (Tokgözoglu, 1999).…”

Section: Effects Of Hazelnut-enriched Diet On Plasma Lipid Profiles Smentioning

confidence: 99%

“…However, recent epidemiologic and clinical studies suggest that frequent nut consumption is associated with favorable plasma lipid profiles (Durak et al, 1999;Edwards et al, 1999;Kris-Etherton et al, 1999b;Zambó n et al, 2000;Rajaram et al, 2001;Hyson et al, 2002;Garg et al, 2003) and reduced risk of coronary heart disease (CHD), cardiovascular disease (CVD), myocardial infarction, atherosclerosis and other chronic ailments (Fraser et al, 1992;Hu and Stampfer, 1999;Sabaté et al, 2000;Albert et al, 2002;Feldman, 2002). The FDA (2003) has recently authorized a health claim about the relationship between the consumption of nuts and reduced risk of CHD.…”

Section: Introductionmentioning

confidence: 99%

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Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men

Mercanlıgil

Arslan

Alasalvar³

et al. 2006

Eur J Clin Nutr

105

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Objective: Frequent consumption of nuts is associated with favorable plasma lipid profiles and reduced risk of coronary heart disease (CHD). This study was conducted to investigate the effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men compared with baseline and control diet, and also to measure the anthropometric parameters, habitual physical activities, nutrient intake and endothelial function. Subjects and design: Fifteen hypercholesterolemic men aged 4878 years were recruited voluntarily. A well-controlled, 2-period (P 1 and P 2 ) study design with a total of 8-week was implemented. In the P 1 , subjects consumed a control diet (low-fat, low-cholesterol and high-carbohydrate). During the P 2 , the control diet was supplemented with MUFA-rich hazelnut (40 g/day), which provided 11.6% of total energy content. Anthropometric parameters and habitual physical activities were recorded. Plasma total and HDL cholesterol, TAG, ApoA-1, Apo B, total homocysteine and glucose concentrations were measured. All parameters and measurements were obtained at baseline and end of each 4-week diet period. Results: Body weights of subjects remained stable throughout the study. Compared with baseline, the hazelnut-enriched diet decreased (Po0.05) the concentrations of VLDL cholesterol, triacylglycerol, apolipoprotein B by 29.5, 31.8, and 9.2%, respectively, while increasing HDL cholesterol concentrations by 12.6%. Total/HDL cholesterol and LDL/HDL cholesterol ratios favorably decreased (Po0.05). Although insignificant there was a decreasing trend for the rest of parameters, particularly in total (5.2%) and LDL cholesterol (3.3%) in subjects consuming a hazelnut-enriched diet compared to that of the baseline. No changes were found in fasting levels of glucose, Apo A-1 and homocysteine between the control and hazelnut-enriched diets. Conclusions: This study demonstrated that a high-fat and high-MUFA-rich hazelnut diet was superior to a low-fat control diet because of favorable changes in plasma lipid profiles of hypercholesterolemic adult men and, thereby positively affecting the CHD risk profile. Sponsorship:

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Section: Effects Of Hazelnut-enriched Diet On Plasma Lipid Profiles Ssupporting

confidence: 85%

Section: Effects Of Hazelnut-enriched Diet On Plasma Lipid Profiles Smentioning

confidence: 98%

Section: Effects Of Hazelnut-enriched Diet On Plasma Lipid Profiles Smentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men

Mercanlıgil

Arslan

Alasalvar³

et al. 2006

Eur J Clin Nutr

105

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“…Studies on properties and bioactivity of this nut to date are limited with respect to other nuts such as walnuts, peanuts, and almonds. Pistachio nut consumption has been shown to have positive effects on serum lipid profile and CVD risk factors in healthy as well as hypercholesterolemic humans [16][17][18][19]. Potential mechanisms of the cardiovascular protective action have been suggested, including effects on plasma stearoyl-CoA desaturase activity [19].…”

Section: Introductionmentioning

confidence: 99%

Polymeric proanthocyanidins from Sicilian pistachio (Pistacia vera L.) nut extract inhibit lipopolysaccharide-induced inflammatory response in RAW 264.7 cells

et al. 2011

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Background Positive effects of pistachio nut consumption on plasma inflammatory biomarkers have been described; however, little is known about molecular events associated with these effects. Purpose We studied the anti-inflammatory activity of a hydrophilic extract from Sicilian Pistacia L. (HPE) in a macrophage model and investigated bioactive components relevant to the observed effects. Methods HPE oligomer/polymer proanthocyanidin fractions were isolated by adsorbance chromatography, and components quantified as anthocyanidins after acidic hydrolysis. Isoflavones were measured by gradient elution HPLC analysis. RAW 264.7 murine macrophages were pre-incubated with either HPE (1-to 20-mg fresh nut equivalents) or its isolated components for 1 h, then washed before stimulating with lipopolysaccharide (LPS) for 24 h. Cell viability and parameters associated with Nuclear Factor-jB (NF-jB) activation were assayed according to established methods including ELISA, Western blot, or cytofluorimetric analysis. Results HPE suppressed nitric oxide (NO) and tumor necrosis factor-a (TNF-a) production and inducible NO-synthase levels dose dependently, whereas inhibited prostaglandin E 2 (PGE 2 ) release and decreased cyclooxygenase-2 content, the lower the HPE amount the higher the effect. Cytotoxic effects were not observed. HPE also caused a dose-dependent decrease in intracellular reactive oxygen species and interfered with the NF-jB activation.Polymeric proanthocyanidins, but not isoflavones, at a concentration comparable with their content in HPE, inhibited NO, PGE 2 , and TNF-a formation, as well as activation of IjB-a. Oligomeric proanthocyanidins showed only minor effects. Conclusions Our results provide molecular evidence of anti-inflammatory activity of pistachio nut and indicate polymeric proanthocyanidins as the bioactive components. The mechanism may involve the redox-sensitive transcription factor NF-jB. Potential effects associated with pistachio nut consumption are discussed in terms of the proanthocyanidin bioavailability.

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Nut Consumption and Blood Lipid Levels

Sabaté¹

2010

Arch Intern Med

374

147

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Effect of Pistachio Nuts on Serum Lipid Levels in Patients with Moderate Hypercholesterolemia

Abstract: Results suggest that eating pistachio nuts instead of other dietary fat calories can improve lipid profiles, thereby decreasing coronary risk. Further studies will be required to confirm these results and to determine the mechanism of this effect.

Cited by 129 publications

References 9 publications

Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men

Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men

Polymeric proanthocyanidins from Sicilian pistachio (Pistacia vera L.) nut extract inhibit lipopolysaccharide-induced inflammatory response in RAW 264.7 cells

Nut Consumption and Blood Lipid Levels

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