Effect of placebo versus prophylactic postoperative amoxicillin on post-(adeno) tonsillectomy morbidity in Tanzanian children: a two-centre, double-blind randomized controlled non-inferiority trial

Katundu, Denis; Chussi, Desderius; Nyombi, Balthazar; Philemon, Rune; Semvua, Hadija; Hannink, Gerjon; Heerbeek, Niels van

doi:10.11604/pamj.2022.42.142.35540

Cited by 2 publications

(3 citation statements)

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“…Findings from this study add value to the understanding of differences in bacterial colonisation of the surface and the core of the palatine tonsils of children from resource-limited settings. 17,[19][20][21] This study focuses on the most common potentially pathogenic bacteria. In the upper respiratory tract, N meningitidis, H influenzae and S pneumoniae were observed to be the most common species in both tonsil sites.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Patient inclusion was as per the published study protocol. 16,17 All swabbing was carried out under general anaesthesia (by author DRK). Adenotonsillectomy was performed by different surgeons.…”

Section: Methodsmentioning

confidence: 99%

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Bacterial colonisation of surface and core of palatine tonsils among Tanzanian children with recurrent chronic tonsillitis and obstructive sleep apnoea who underwent (adeno)tonsillectomy

et al. 2023

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Objective Acute and chronic tonsillitis are frequently treated with antibiotics. This study aimed to understand the presence of pathogenic micro-organisms on the surface and core of chronically infected tonsils among Tanzanian children. Methods The study enrolled children undergoing adenotonsillectomy. Surface and core tonsillar swabs were taken. Quantitative polymerase chain reaction was performed for Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, Neisseria meningitidis and Pseudomonas aeruginosa. Results Surface and core combined, isolated N meningitidis (86.1 per cent) was found the most, followed by H influenzae (74.9 per cent), S pneumoniae (42.6 per cent) and S aureus (28.7 per cent). M catarrhalis and P aeruginosa were only found in a few patients, 5.6 per cent and 0.8 per cent respectively. Conclusion Colonisation of the tonsillar surface and core has been found. Potentially pathogenic micro-organisms are likely to be missed based on a throat swab. Hence, the practice of surface tonsillar swabbing may be misleading or insufficient.

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Section: Discussionmentioning

confidence: 99%